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ENZYME entry: EC 1.1.1.292

Accepted Name
1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming).
Alternative Name(s)
1,5-anhydro-D-fructose reductase.
AFR.
Reaction catalysed
1,5-anhydro-D-mannitol + NADP(+) <=> 1,5-anhydro-D-fructose + H(+) + NADPH
Comment(s)
  • Present in some but not all Rhizobium species.
  • Differs from hepatic 1,5-anhydro-D-fructose reductase, which yields 1,5-anhydro-D-glucitol as the product (see EC 1.1.1.263).
  • In Sinorhizobium morelense, the product of the reaction, 1,5-anhydro- D-mannitol, can be further metabolized to D-mannose.
  • Also reduces 1,5-anhydro-D-erythro-hexo-2,3-diulose and 2-ketoaldoses (called osones), such as D-glucosone (D-arabino-hexos-2-ulose) and 6-deoxy-D-glucosone.
  • Does not reduce common aldoses and ketoses, or non-sugar aldehydes and ketones.
Cross-references
BRENDA1.1.1.292
EC2PDB1.1.1.292
ExplorEnz1.1.1.292
PRIAM enzyme-specific profiles1.1.1.292
KEGG Ligand Database for Enzyme Nomenclature1.1.1.292
IUBMB Enzyme Nomenclature1.1.1.292
IntEnz1.1.1.292
MEDLINEFind literature relating to 1.1.1.292
MetaCyc1.1.1.292
Rhea expert-curated reactions1.1.1.292
UniProtKB/Swiss-Prot
Q2I8V6, AFR_ENSAD;  Q92KZ3, AFR_RHIME;  

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