ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.1.1.292

Accepted Name

1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming).

Alternative Name(s)

1,5-anhydro-D-fructose reductase.

AFR.

Reaction catalysed

1,5-anhydro-D-mannitol + NADP(+) <=> 1,5-anhydro-D-fructose + NADPH

Comment(s)

Present in some but not all Rhizobium species.
Differs from hepatic 1,5-anhydro-D-fructose reductase, which yields 1,5-anhydro-D-glucitol as the product (see EC 1.1.1.263).
In Sinorhizobium morelense, the product of the reaction, 1,5-anhydro- D-mannitol, can be further metabolized to D-mannose.
Also reduces 1,5-anhydro-D-erythro-hexo-2,3-diulose and 2-ketoaldoses (called osones), such as D-glucosone (D-arabino-hexos-2-ulose) and 6-deoxy-D-glucosone.
Does not reduce common aldoses and ketoses, or non-sugar aldehydes and ketones.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature