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ENZYME entry: EC 1.1.1.298

Accepted Name
3-hydroxypropionate dehydrogenase (NADP(+)).
Alternative Name(s)
3-hydroxypropanoate dehydrogenase (NADP(+)).
Reaction catalysed
3-hydroxypropanoate + NADP(+) <=> 3-oxopropanoate + H(+) + NADPH
Comment(s)
  • Catalyzes the reduction of 3-oxopropanoate to 3-hydroxypropanoate, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutyrate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and archaea, respectively.
  • The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyzes the upstream reaction in the pathway, EC 1.2.1.75.
  • Different from EC 1.1.1.59 by cofactor preference.
Cross-references
BRENDA1.1.1.298
EC2PDB1.1.1.298
ExplorEnz1.1.1.298
PRIAM enzyme-specific profiles1.1.1.298
KEGG Ligand Database for Enzyme Nomenclature1.1.1.298
IUBMB Enzyme Nomenclature1.1.1.298
IntEnz1.1.1.298
MEDLINEFind literature relating to 1.1.1.298
MetaCyc1.1.1.298
Rhea expert-curated reactions1.1.1.298
UniProtKB/Swiss-Prot
A7MFX7, RUTE_CROS8;  A7ZKB3, RUTE_ECO24;  B7UNZ1, RUTE_ECO27;  
B7MIF5, RUTE_ECO45;  B7LFB8, RUTE_ECO55;  Q8XAU9, RUTE_ECO57;  
B5YU50, RUTE_ECO5E;  B7NLB8, RUTE_ECO7I;  B7MTF1, RUTE_ECO81;  
B7M8Z3, RUTE_ECO8A;  C4ZQD6, RUTE_ECOBW;  B1X9C9, RUTE_ECODH;  
A7ZYW3, RUTE_ECOHS;  A1A9R3, RUTE_ECOK1;  Q0TJ59, RUTE_ECOL5;  
Q8FJ44, RUTE_ECOL6;  B1IV89, RUTE_ECOLC;  P75894, RUTE_ECOLI;  
B7N3G4, RUTE_ECOLU;  B6I984, RUTE_ECOSE;  B1LIZ7, RUTE_ECOSM;  
Q1RDK9, RUTE_ECOUT;  A4W921, RUTE_ENT38;  B5XXN4, RUTE_KLEP3;  
A6T798, RUTE_KLEP7;  Q32HQ3, RUTE_SHIDS;  Q0T626, RUTE_SHIF8;  
Q83RV4, RUTE_SHIFL;  Q3Z3A5, RUTE_SHISS;  A1JMW8, RUTE_YERE8;  
Q8X505, YDFG_ECO57;  Q8FHD2, YDFG_ECOL6;  P39831, YDFG_ECOLI;  
P69935, YDFG_SALTI;  P69936, YDFG_SALTY;  Q83RE8, YDFG_SHIFL;  

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