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ENZYME

ENZYME entry: EC 1.2.1.75

Accepted Name
malonyl CoA reductase (malonate semialdehyde-forming)
Alternative Name(s)
malonyl CoA reductase (NADP)
NADP-dependent malonyl CoA reductase
Reaction catalysed
3-oxopropanoate + CoA + NADP(+) <=> H(+) + malonyl-CoA + NADPH
Comment(s)
  • Catalyzes the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutyrate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and some thermoacidophilic archaea, respectively.
  • The enzyme from Sulfolobus tokodaii has been purified, and found to contain one RNA molecule per two subunits.
  • The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyzes the next reaction in the pathway, EC 1.1.1.298.
Cross-references
BRENDA1.2.1.75
EC2PDB1.2.1.75
ExplorEnz1.2.1.75
PRIAM enzyme-specific profiles1.2.1.75
KEGG Ligand Database for Enzyme Nomenclature1.2.1.75
IUBMB Enzyme Nomenclature1.2.1.75
IntEnz1.2.1.75
MEDLINEFind literature relating to 1.2.1.75
MetaCyc1.2.1.75
Rhea expert-curated reactions1.2.1.75
UniProtKB/Swiss-Prot
A4YEN2, MCR_METS5Q96YK1, MCR_SULTO

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