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ENZYME entry: EC 1.1.1.299

Accepted Name
malate dehydrogenase [NAD(P)(+)].
Reaction catalysed
  • (S)-malate + NAD(+) <=> H(+) + NADH + oxaloacetate
  • (S)-malate + NADP(+) <=> H(+) + NADPH + oxaloacetate
Comment(s)
  • This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyzes only the reduction of oxaloacetate, and can use NAD(+) and NADP(+) with similar specific activity.
  • Different from EC 1.1.1.37, EC 1.1.1.82 and EC 1.1.5.4.
Cross-references
BRENDA1.1.1.299
EC2PDB1.1.1.299
ExplorEnz1.1.1.299
PRIAM enzyme-specific profiles1.1.1.299
KEGG Ligand Database for Enzyme Nomenclature1.1.1.299
IUBMB Enzyme Nomenclature1.1.1.299
IntEnz1.1.1.299
MEDLINEFind literature relating to 1.1.1.299
MetaCyc1.1.1.299
Rhea expert-curated reactions1.1.1.299
UniProtKB/Swiss-Prot
Q9YEA1, MDH_AERPE;  Q8TWG5, MDH_METKA;  Q6LZI3, MDH_METMP;  
Q2NGI3, MDH_METST;  O26290, MDH_METTH;  D9PVI7, MDH_METTM;  

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