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ENZYME

ENZYME entry: EC 1.1.1.3

Accepted Name
homoserine dehydrogenase
Reaction catalysed
  • L-homoserine + NAD(+) <=> H(+) + L-aspartate 4-semialdehyde + NADH
  • L-homoserine + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH
Comment(s)
  • The enzyme from Saccharomyces cerevisiae acts most rapidly with NAD(+); the Neurospora enzyme with NADP(+).
  • The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 2.7.2.4.
Cross-references
BRENDA1.1.1.3
EC2PDB1.1.1.3
ExplorEnz1.1.1.3
PRIAM enzyme-specific profiles1.1.1.3
KEGG Ligand Database for Enzyme Nomenclature1.1.1.3
IUBMB Enzyme Nomenclature1.1.1.3
IntEnz1.1.1.3
MEDLINEFind literature relating to 1.1.1.3
MetaCyc1.1.1.3
Rhea expert-curated reactions1.1.1.3
UniProtKB/Swiss-Prot
P00561, AK1H_ECOLIP27725, AK1H_SERMAP00562, AK2H_ECOLI
Q9SA18, AKH1_ARATHP49079, AKH1_MAIZEO81852, AKH2_ARATH
P49080, AKH2_MAIZEP57290, AKH_BUCAIQ8K9U9, AKH_BUCAP
Q89AR4, AKH_BUCBPP37142, AKH_DAUCAP44505, AKH_HAEIN
P19582, DHOM_BACSUP08499, DHOM_CORGLQ5B998, DHOM_EMENI
Q9ZL20, DHOM_HELPJP56429, DHOM_HELPYQ9CGD8, DHOM_LACLA
P52985, DHOM_LACLCP37143, DHOM_METGLQ58997, DHOM_METJA
P63630, DHOM_MYCBOP46806, DHOM_MYCLEP9WPX0, DHOM_MYCTO
P9WPX1, DHOM_MYCTUP29365, DHOM_PSEAEO94671, DHOM_SCHPO
P52986, DHOM_SYNY3P31116, DHOM_YEASTP37144, DHON_METGL

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