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ENZYME entry: EC 1.1.1.34

Accepted Name
Hydroxymethylglutaryl-CoA reductase (NADPH).
Alternative Name(s)
3-hydroxy-3-methylglutaryl-coenzyme A reductase.
HMG-CoA reductase.
Reaction catalysed
(R)-mevalonate + CoA + 2 NADP(+) <=> (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH
Comment(s)
The enzyme is inactivated by EC 2.7.11.31 and reactivated by EC 3.1.3.47.
Cross-references
PROSITEPDOC00064
BRENDA1.1.1.34
EC2PDB1.1.1.34
ExplorEnz1.1.1.34
PRIAM enzyme-specific profiles1.1.1.34
KEGG Ligand Database for Enzyme Nomenclature1.1.1.34
IUBMB Enzyme Nomenclature1.1.1.34
IntEnz1.1.1.34
MEDLINEFind literature relating to 1.1.1.34
MetaCyc1.1.1.34
Rhea expert-curated reactions1.1.1.34
UniProtKB/Swiss-Prot
P14891, HMDH1_ARATH;  Q4WHZ1, HMDH1_ASPFU;  P34135, HMDH1_DICDI;  
I1RXX1, HMDH1_GIBZE;  O64966, HMDH1_GOSHI;  P29057, HMDH1_HEVBR;  
A2X8W3, HMDH1_ORYSI;  Q0DY59, HMDH1_ORYSJ;  P48020, HMDH1_SOLTU;  
P12683, HMDH1_YEAST;  P43256, HMDH2_ARATH;  Q4WSY2, HMDH2_ASPFU;  
Q9XEL8, HMDH2_CAPAN;  P34136, HMDH2_DICDI;  O64967, HMDH2_GOSHI;  
P29058, HMDH2_HEVBR;  P48022, HMDH2_SOLLC;  Q41437, HMDH2_SOLTU;  
P12684, HMDH2_YEAST;  Q00583, HMDH3_HEVBR;  Q9XHL5, HMDH3_ORYSJ;  
Q41438, HMDH3_SOLTU;  Q9YAS4, HMDH_AERPE;  O76819, HMDH_AGRIP;  
O28538, HMDH_ARCFU;  Q9Y7D2, HMDH_ASPTE;  Q0C8L9, HMDH_ASPTN;  
P54960, HMDH_BLAGE;  A7Z064, HMDH_BOVIN;  P48021, HMDH_CAMAC;  
A0A1D8PD39, HMDH_CANAL;  Q03163, HMDH_CATRO;  P00347, HMDH_CRIGR;  
O74164, HMDH_CYBJA;  P14773, HMDH_DROME;  B2KX91, HMDH_GANLU;  
S0DQM8, HMDH_GIBF5;  P0CT44, HMDH_GIBFU;  B0R6J9, HMDH_HALS3;  
Q59468, HMDH_HALVD;  P04035, HMDH_HUMAN;  O24594, HMDH_MAIZE;  
P09610, HMDH_MESAU;  Q58116, HMDH_METJA;  O26662, HMDH_METTH;  
Q01237, HMDH_MOUSE;  Q01559, HMDH_NICSY;  Q12649, HMDH_PHYB8;  
Q1W675, HMDH_PIG;  Q5R6N3, HMDH_PONAB;  Q9V1R3, HMDH_PYRAB;  
O59469, HMDH_PYRHO;  Q29512, HMDH_RABIT;  P51639, HMDH_RAT;  
O08424, HMDH_SACS2;  P16237, HMDH_SCHMA;  Q10283, HMDH_SCHPO;  
P16393, HMDH_STRPU;  P20715, HMDH_XENLA;  A0A0A1C3I2, HMGR1_PANGI;  
A0A0A1C930, HMR2A_PANGI;  U5JCC6, HMR2B_PANGI;  Q8J0F4, MLCD_PENCI;  
Q3S2U3, MOKG_MONPI;  C8VN86, PBCC_EMENI;  

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