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ENZYME entry: EC 1.1.1.34

Accepted Name
hydroxymethylglutaryl-CoA reductase (NADPH)
Alternative Name(s)
3-hydroxy-3-methylglutaryl-coenzyme A reductase
HMG-CoA reductase
Reaction catalysed
(R)-mevalonate + CoA + 2 NADP(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH
Comment(s)
The enzyme is inactivated by EC 2.7.11.31 and reactivated by EC 3.1.3.47.
Cross-references
BRENDA1.1.1.34
EC2PDB1.1.1.34
ExplorEnz1.1.1.34
PRIAM enzyme-specific profiles1.1.1.34
KEGG Ligand Database for Enzyme Nomenclature1.1.1.34
IUBMB Enzyme Nomenclature1.1.1.34
IntEnz1.1.1.34
MEDLINEFind literature relating to 1.1.1.34
MetaCyc1.1.1.34
Rhea expert-curated reactions1.1.1.34
UniProtKB/Swiss-Prot
P14891, HMDH1_ARATHQ4WHZ1, HMDH1_ASPFUP34135, HMDH1_DICDI
I1RXX1, HMDH1_GIBZEO64966, HMDH1_GOSHIP29057, HMDH1_HEVBR
A2X8W3, HMDH1_ORYSIQ0DY59, HMDH1_ORYSJP48020, HMDH1_SOLTU
P12683, HMDH1_YEASTP43256, HMDH2_ARATHQ4WSY2, HMDH2_ASPFU
Q9XEL8, HMDH2_CAPANP34136, HMDH2_DICDIO64967, HMDH2_GOSHI
P29058, HMDH2_HEVBRP48022, HMDH2_SOLLCQ41437, HMDH2_SOLTU
P12684, HMDH2_YEASTQ00583, HMDH3_HEVBRQ9XHL5, HMDH3_ORYSJ
Q41438, HMDH3_SOLTUQ9YAS4, HMDH_AERPEO76819, HMDH_AGRIP
O28538, HMDH_ARCFUQ9Y7D2, HMDH_ASPTEQ0C8L9, HMDH_ASPTN
P54960, HMDH_BLAGEA7Z064, HMDH_BOVINP48021, HMDH_CAMAC
A0A1D8PD39, HMDH_CANALQ03163, HMDH_CATROP00347, HMDH_CRIGR
O74164, HMDH_CYBJAP14773, HMDH_DROMEB2KX91, HMDH_GANLU
S0DQM8, HMDH_GIBF5P0CT44, HMDH_GIBFUB0R6J9, HMDH_HALS3
Q59468, HMDH_HALVDP04035, HMDH_HUMANO24594, HMDH_MAIZE
P09610, HMDH_MESAUQ58116, HMDH_METJAO26662, HMDH_METTH
Q01237, HMDH_MOUSEQ01559, HMDH_NICSYQ12649, HMDH_PHYB8
Q1W675, HMDH_PIGQ5R6N3, HMDH_PONABQ9V1R3, HMDH_PYRAB
O59469, HMDH_PYRHOQ29512, HMDH_RABITP51639, HMDH_RAT
O08424, HMDH_SACS2P16237, HMDH_SCHMAQ10283, HMDH_SCHPO
P16393, HMDH_STRPUP20715, HMDH_XENLAA0A0A1C3I2, HMGR1_PANGI
A0A0A1C930, HMR2A_PANGIU5JCC6, HMR2B_PANGIQ8J0F4, MLCD_PENCI
Q3S2U3, MOKG_MONPIC8VN86, PBCC_EMENI

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