A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 188.8.131.52
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|[Hydroxymethylglutaryl-CoA reductase (NADPH)] kinase.
|3-hydroxy-3-methylglutaryl coenzyme A reductase kinase.|
|3-hydroxy-3-methylglutaryl-CoA reductase kinase.|
|[Hydroxymethylglutaryl-CoA reductase (NADPH(2))] kinase.|
|AMP-activated protein kinase.|
|Beta-hydroxy-beta-methylglutaryl-CoA reductase kinase.|
|HMG-CoA reductase kinase.|
|Hydroxymethylglutaryl coenzyme A reductase kinase.|
|Hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating).|
|Hydroxymethylglutaryl-CoA reductase kinase.|
|ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] <=> ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate|
- Activated by AMP.
- EC 184.108.40.206 is inactivated by the phosphorylation of the enzyme
- Histones can also act as acceptors.
- Can also phosphorylate EC 220.127.116.11 and EC 18.104.22.168.
- Thr-172 within the catalytic subunit (alpha-subunit) is the major
site phosphorylated by the AMP-activated protein kinase kinase.
- GTP can act instead of ATP.
- Formerly EC 22.214.171.124.
|PRIAM enzyme-specific profiles||126.96.36.199|
|KEGG Ligand Database for Enzyme Nomenclature||188.8.131.52|
|IUBMB Enzyme Nomenclature||184.108.40.206|
|MEDLINE||Find literature relating to 220.127.116.11|
|Q13131, AAPK1_HUMAN; ||Q5EG47, AAPK1_MOUSE; ||Q09136, AAPK1_PIG; |
|Q5RDH5, AAPK1_PONAB; ||P54645, AAPK1_RAT; ||P54646, AAPK2_HUMAN; |
|Q8BRK8, AAPK2_MOUSE; ||Q28948, AAPK2_PIG; ||Q5RD00, AAPK2_PONAB; |
|Q09137, AAPK2_RAT; |
entries corresponding to 2.7.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-