ENZYME entry: EC 22.214.171.124
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|[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase.
|[hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase.|
|3-hydroxy-3-methylglutaryl-CoA reductase kinase.|
|3-hydroxy-3-methylglutaryl coenzyme A reductase kinase.|
|AMP-activated protein kinase.|
|beta-hydroxy-beta-methylglutaryl-CoA reductase kinase.|
|HMG-CoA reductase kinase.|
|hydroxymethylglutaryl-CoA reductase kinase.|
|hydroxymethylglutaryl coenzyme A reductase kinase.|
|hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating).|
|ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] <=> ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]|
- Activated by AMP.
- EC 126.96.36.199 is inactivated by the phosphorylation of the enzyme
- Histones can also act as acceptors.
- Can also phosphorylate EC 188.8.131.52 and EC 184.108.40.206.
- Thr-172 within the catalytic subunit (alpha-subunit) is the major
site phosphorylated by the AMP-activated protein kinase kinase.
- GTP can act instead of ATP.
- Formerly EC 220.127.116.11.
|PRIAM enzyme-specific profiles||18.104.22.168|
|KEGG Ligand Database for Enzyme Nomenclature||22.214.171.124|
|IUBMB Enzyme Nomenclature||126.96.36.199|
|MEDLINE||Find literature relating to 188.8.131.52|
|Rhea expert-curated reactions||184.108.40.206|
|Q13131, AAPK1_HUMAN; ||Q5EG47, AAPK1_MOUSE; ||Q09136, AAPK1_PIG; |
|Q5RDH5, AAPK1_PONAB; ||P54645, AAPK1_RAT; ||P54646, AAPK2_HUMAN; |
|Q8BRK8, AAPK2_MOUSE; ||Q28948, AAPK2_PIG; ||Q5RD00, AAPK2_PONAB; |
|Q09137, AAPK2_RAT; |
entries corresponding to 2.7.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-