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ENZYME entry: EC 2.7.11.31

Accepted Name
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase.
Alternative Name(s)
[hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase.
3-hydroxy-3-methylglutaryl-CoA reductase kinase.
3-hydroxy-3-methylglutaryl coenzyme A reductase kinase.
AMP-activated protein kinase.
AMPK.
beta-hydroxy-beta-methylglutaryl-CoA reductase kinase.
HMG-CoA reductase kinase.
hydroxymethylglutaryl-CoA reductase kinase.
hydroxymethylglutaryl coenzyme A reductase kinase.
hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating).
reductase kinase.
Reaction catalysed
ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] <=> ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]
Comment(s)
  • Activated by AMP.
  • EC 1.1.1.34 is inactivated by the phosphorylation of the enzyme protein.
  • Histones can also act as acceptors.
  • Can also phosphorylate EC 6.4.1.2 and EC 3.1.1.79.
  • Thr-172 within the catalytic subunit (alpha-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase.
  • GTP can act instead of ATP.
  • Formerly EC 2.7.1.109.
Cross-references
BRENDA2.7.11.31
EC2PDB2.7.11.31
ExplorEnz2.7.11.31
PRIAM enzyme-specific profiles2.7.11.31
KEGG Ligand Database for Enzyme Nomenclature2.7.11.31
IUBMB Enzyme Nomenclature2.7.11.31
IntEnz2.7.11.31
MEDLINEFind literature relating to 2.7.11.31
MetaCyc2.7.11.31
Rhea expert-curated reactions2.7.11.31
UniProtKB/Swiss-Prot
Q13131, AAPK1_HUMAN;  Q5EG47, AAPK1_MOUSE;  Q09136, AAPK1_PIG;  
Q5RDH5, AAPK1_PONAB;  P54645, AAPK1_RAT;  P54646, AAPK2_HUMAN;  
Q8BRK8, AAPK2_MOUSE;  Q28948, AAPK2_PIG;  Q5RD00, AAPK2_PONAB;  
Q09137, AAPK2_RAT;  

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