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ENZYME

ENZYME entry: EC 2.7.11.31

PURL: https://purl.expasy.org/enzyme/EC/2.7.11.31
Accepted Name
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
Alternative Name(s)
[hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase
3-hydroxy-3-methylglutaryl-CoA reductase kinase
3-hydroxy-3-methylglutaryl coenzyme A reductase kinase
AMP-activated protein kinase
AMPK
beta-hydroxy-beta-methylglutaryl-CoA reductase kinase
HMG-CoA reductase kinase
hydroxymethylglutaryl-CoA reductase kinase
hydroxymethylglutaryl coenzyme A reductase kinase
hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating)
reductase kinase
Reaction catalysed
L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] + ATP = O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] + ADP + H(+)
Comment(s)
  • Activated by AMP.
  • EC 1.1.1.34 is inactivated by the phosphorylation of the enzyme protein.
  • Histones can also act as acceptors.
  • Can also phosphorylate EC 6.4.1.2 and EC 3.1.1.79.
  • Thr-172 within the catalytic subunit (alpha-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase.
  • GTP can act instead of ATP.
  • Formerly EC 2.7.1.109 and EC 2.7.11.27.
Cross-references
BRENDA2.7.11.31
EC2PDB2.7.11.31
ExplorEnz2.7.11.31
KEGG Ligand Database for Enzyme Nomenclature2.7.11.31
IUBMB Enzyme Nomenclature2.7.11.31
MEDLINEFind literature relating to 2.7.11.31
MetaCyc2.7.11.31
Rhea expert-curated reactions2.7.11.31
UniProtKB/Swiss-Prot
Q13131, AAPK1_HUMANQ5EG47, AAPK1_MOUSEQ09136, AAPK1_PIG
Q5RDH5, AAPK1_PONABP54645, AAPK1_RATP54646, AAPK2_HUMAN
Q8BRK8, AAPK2_MOUSEQ28948, AAPK2_PIGQ5RD00, AAPK2_PONAB
Q09137, AAPK2_RAT

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