ENZYME entry: EC 2.7.11.31
Accepted Name |
[Hydroxymethylglutaryl-CoA reductase (NADPH)] kinase.
|
Alternative Name(s) |
3-hydroxy-3-methylglutaryl coenzyme A reductase kinase. |
3-hydroxy-3-methylglutaryl-CoA reductase kinase. |
[Hydroxymethylglutaryl-CoA reductase (NADPH(2))] kinase. |
AMP-activated protein kinase. |
AMPK. |
Beta-hydroxy-beta-methylglutaryl-CoA reductase kinase. |
HMG-CoA reductase kinase. |
Hydroxymethylglutaryl coenzyme A reductase kinase. |
Hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating). |
Hydroxymethylglutaryl-CoA reductase kinase. |
Reductase kinase. |
Reaction catalysed |
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] <=> ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate |
Comment(s) |
- Activated by AMP.
- EC 1.1.1.34 is inactivated by the phosphorylation of the enzyme
protein.
- Histones can also act as acceptors.
- Can also phosphorylate EC 6.4.1.2 and EC 3.1.1.79.
- Thr-172 within the catalytic subunit (alpha-subunit) is the major
site phosphorylated by the AMP-activated protein kinase kinase.
- GTP can act instead of ATP.
- Formerly EC 2.7.1.109.
|
Cross-references |
BRENDA | 2.7.11.31 |
EC2PDB | 2.7.11.31 |
ExplorEnz | 2.7.11.31 |
PRIAM enzyme-specific profiles | 2.7.11.31 |
KEGG Ligand Database for Enzyme Nomenclature | 2.7.11.31 |
IUBMB Enzyme Nomenclature | 2.7.11.31 |
IntEnz | 2.7.11.31 |
MEDLINE | Find literature relating to 2.7.11.31 |
MetaCyc | 2.7.11.31 |
Rhea expert-curated reactions | 2.7.11.31 |
UniProtKB/Swiss-Prot |
Q13131, AAPK1_HUMAN; | Q5EG47, AAPK1_MOUSE; | Q09136, AAPK1_PIG; |
Q5RDH5, AAPK1_PONAB; | P54645, AAPK1_RAT; | P54646, AAPK2_HUMAN; |
Q8BRK8, AAPK2_MOUSE; | Q28948, AAPK2_PIG; | Q5RD00, AAPK2_PONAB; |
Q09137, AAPK2_RAT; |
|
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