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ENZYME entry: EC 1.1.1.346

Accepted Name
2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming).
Alternative Name(s)
2,5-diketo-D-gluconate-reductase.
Reaction catalysed
2-dehydro-L-idonate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH
Comment(s)
  • The enzyme is involved in ketogluconate metabolism, and catalyzes the reaction in vivo in the reverse direction to that shown.
  • It is used in the commercial microbial production of ascorbate.
  • cf. EC 1.1.1.274.
Cross-references
BRENDA1.1.1.346
EC2PDB1.1.1.346
ExplorEnz1.1.1.346
PRIAM enzyme-specific profiles1.1.1.346
KEGG Ligand Database for Enzyme Nomenclature1.1.1.346
IUBMB Enzyme Nomenclature1.1.1.346
IntEnz1.1.1.346
MEDLINEFind literature relating to 1.1.1.346
MetaCyc1.1.1.346
Rhea expert-curated reactions1.1.1.346
UniProtKB/Swiss-Prot
P06632, DKGA_CORSC;  Q8XBT6, DKGA_ECO57;  P58744, DKGA_SALTI;  
Q8ZM06, DKGA_SALTY;  Q8ZI40, DKGA_YERPE;  Q8X7Z7, DKGB_ECO57;  
P30863, DKGB_ECOLI;  Q8Z988, DKGB_SALTI;  Q8ZRM7, DKGB_SALTY;  
Q8ZH36, DKGB_YERPE;  

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