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ENZYME

ENZYME entry: EC 1.1.1.346

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.346
Accepted Name
2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)
Alternative Name(s)
2,5-diketo-D-gluconate-reductase
Reaction catalysed
2-dehydro-L-idonate + NADP(+) = 2,5-didehydro-D-gluconate + NADPH + H(+)
Comment(s)
  • The enzyme is involved in ketogluconate metabolism, and catalyzes the reaction in vivo in the reverse direction to that shown.
  • It is used in the commercial microbial production of ascorbate. cf. EC 1.1.1.274.
Cross-references
BRENDA1.1.1.346
EC2PDB1.1.1.346
ExplorEnz1.1.1.346
KEGG Ligand Database for Enzyme Nomenclature1.1.1.346
IUBMB Enzyme Nomenclature1.1.1.346
MEDLINEFind literature relating to 1.1.1.346
MetaCyc1.1.1.346
Rhea expert-curated reactions1.1.1.346
UniProtKB/Swiss-Prot
P06632, DKGA_CORSCQ46857, DKGA_ECOLIP30863, DKGB_ECOLI

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