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ENZYME

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ENZYME entry: EC 1.1.1.346

Accepted Name
2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)
Alternative Name(s)
2,5-diketo-D-gluconate-reductase
Reaction catalysed
2-dehydro-L-idonate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH
Comment(s)
  • The enzyme is involved in ketogluconate metabolism, and catalyzes the reaction in vivo in the reverse direction to that shown.
  • It is used in the commercial microbial production of ascorbate. cf. EC 1.1.1.274.
Cross-references
BRENDA1.1.1.346
EC2PDB1.1.1.346
ExplorEnz1.1.1.346
PRIAM enzyme-specific profiles1.1.1.346
KEGG Ligand Database for Enzyme Nomenclature1.1.1.346
IUBMB Enzyme Nomenclature1.1.1.346
IntEnz1.1.1.346
MEDLINEFind literature relating to 1.1.1.346
MetaCyc1.1.1.346
Rhea expert-curated reactions1.1.1.346
UniProtKB/Swiss-Prot
P06632, DKGA_CORSCQ8XBT6, DKGA_ECO57P58744, DKGA_SALTI
Q8ZM06, DKGA_SALTYQ8ZI40, DKGA_YERPEQ8X7Z7, DKGB_ECO57
P30863, DKGB_ECOLIQ8Z988, DKGB_SALTIQ8ZRM7, DKGB_SALTY
Q8ZH36, DKGB_YERPE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
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