ENZYME entry: EC 1.1.1.346
Accepted Name |
2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming).
|
Alternative Name(s) |
2,5-diketo-D-gluconate-reductase. |
Reaction catalysed |
2-dehydro-L-idonate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH |
Comment(s) |
- The enzyme is involved in ketogluconate metabolism, and catalyzes the
reaction in vivo in the reverse direction to that shown.
- It is used in the commercial microbial production of ascorbate.
- cf. EC 1.1.1.274.
|
Cross-references |
BRENDA | 1.1.1.346 |
EC2PDB | 1.1.1.346 |
ExplorEnz | 1.1.1.346 |
PRIAM enzyme-specific profiles | 1.1.1.346 |
KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.346 |
IUBMB Enzyme Nomenclature | 1.1.1.346 |
IntEnz | 1.1.1.346 |
MEDLINE | Find literature relating to 1.1.1.346 |
MetaCyc | 1.1.1.346 |
Rhea expert-curated reactions | 1.1.1.346 |
UniProtKB/Swiss-Prot |
P06632, DKGA_CORSC; | Q8XBT6, DKGA_ECO57; | P58744, DKGA_SALTI; |
Q8ZM06, DKGA_SALTY; | Q8ZI40, DKGA_YERPE; | Q8X7Z7, DKGB_ECO57; |
P30863, DKGB_ECOLI; | Q8Z988, DKGB_SALTI; | Q8ZRM7, DKGB_SALTY; |
Q8ZH36, DKGB_YERPE; |
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