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ENZYME entry: EC 1.1.1.364

Accepted Name
dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase.
Alternative Name(s)
dTDP-4-dehydro-6-deoxygulose reductase.
Reaction catalysed
  • dTDP-6-deoxy-alpha-D-allose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH
  • dTDP-6-deoxy-alpha-D-allose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH
Comment(s)
The enzyme forms an activated deoxy-alpha-D-allose, which is converted to mycinose after attachment to the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II.
Cross-references
BRENDA1.1.1.364
EC2PDB1.1.1.364
ExplorEnz1.1.1.364
PRIAM enzyme-specific profiles1.1.1.364
KEGG Ligand Database for Enzyme Nomenclature1.1.1.364
IUBMB Enzyme Nomenclature1.1.1.364
IntEnz1.1.1.364
MEDLINEFind literature relating to 1.1.1.364
MetaCyc1.1.1.364
Rhea expert-curated reactions1.1.1.364
UniProtKB/Swiss-Prot
Q5SFA6, CHMD_STRBI;  Q331Q7, GERKI_STRSQ;  

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