Due to scheduled maintenance work, this service will not be available from Tuesday August 23rd 06:00 pm until Wednesday August 24th 08:00 am CEST
. Apologies for the inconvenience.
ENZYME entry: EC 220.127.116.115
View entry in original ENZYME format
View entry in raw text format (no links)
|L-2-hydroxycarboxylate dehydrogenase [NAD(P)(+)].
- a (2S)-2-hydroxycarboxylate + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH
- a (2S)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + H(+) + NADPH
- The enzyme from the archaeon Methanocaldococcus jannaschii catalyzes
the reversible oxidation of (2R)-3-sulfolactate and (S)-malate to
3-sulfopyruvate and oxaloacetate, respectively (note that (2R)-3-
sulfolactate has the same stereochemical configuration as (2S)-2-
- The enzyme can use both NADH and NADPH, although activity is higher
- The oxidation of (2R)-3-sulfolactate was observed only in the
presence of NADP(+).
- The same organism also possesses an NAD(+)-specific enzyme with
similar activity, cf. EC 18.104.22.1687.
|PRIAM enzyme-specific profiles||22.214.171.1245|
|KEGG Ligand Database for Enzyme Nomenclature||126.96.36.1995|
|IUBMB Enzyme Nomenclature||188.8.131.525|
|MEDLINE||Find literature relating to 184.108.40.2065|
|Rhea expert-curated reactions||220.127.116.115|
entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-