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ENZYME entry: EC 1.1.1.383

Accepted Name
ketol-acid reductoisomerase [NAD(P)(+)].
Reaction catalysed
  • (2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) <=> (2S)-2-acetolactate + H(+) + NADH
  • (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) <=> (2S)-2-acetolactate + H(+) + NADPH
Comment(s)
The enzyme, characterized from the bacteria Hydrogenobaculum sp. and Syntrophomonas wolfei subsp. wolfei and from the archaea Metallosphaera sedula and Ignisphaera aggregans, can use both NADH and NADPH with similar efficiency (cf. EC 1.1.1.86 and EC 1.1.1.382).
Cross-references
BRENDA1.1.1.383
EC2PDB1.1.1.383
ExplorEnz1.1.1.383
PRIAM enzyme-specific profiles1.1.1.383
KEGG Ligand Database for Enzyme Nomenclature1.1.1.383
IUBMB Enzyme Nomenclature1.1.1.383
IntEnz1.1.1.383
MEDLINEFind literature relating to 1.1.1.383
MetaCyc1.1.1.383
Rhea expert-curated reactions1.1.1.383
UniProtKB/Swiss-Prot
O28294, ILVC_ARCFU;  B4U6I9, ILVC_HYDS0;  E0SRA9, ILVC_IGNAA;  
A4YI15, ILVC_METS5;  Q0AV19, ILVC_SYNWW;  

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