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ENZYME entry: EC 1.1.1.392

Accepted Name
3alpha-hydroxycholanate dehydrogenase (NADP(+)).
Alternative Name(s)
alpha-hydroxy-cholanate dehydrogenase.
Reaction catalysed
lithocholate + NADP(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADPH
Comment(s)
  • This bacterial enzyme is involved in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids) via a 3-oxo intermediate.
  • The enzyme catalyzes a reversible reaction in vitro.
  • Also acts on related bile acids.
  • Cf. EC 1.1.1.52.
Cross-references
BRENDA1.1.1.392
EC2PDB1.1.1.392
ExplorEnz1.1.1.392
PRIAM enzyme-specific profiles1.1.1.392
KEGG Ligand Database for Enzyme Nomenclature1.1.1.392
IUBMB Enzyme Nomenclature1.1.1.392
IntEnz1.1.1.392
MEDLINEFind literature relating to 1.1.1.392
MetaCyc1.1.1.392
Rhea expert-curated reactions1.1.1.392
UniProtKB/Swiss-Prot
A7B3K3, 3AHDP_RUMGV

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