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ENZYME entry: EC 1.1.1.392
| Accepted Name |
|---|
| 3alpha-hydroxycholanate dehydrogenase (NADP(+)).
|
| Alternative Name(s) |
|---|
| alpha-hydroxy-cholanate dehydrogenase. |
| Reaction catalysed |
|---|
| lithocholate + NADP(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADPH |
| Comment(s) |
|---|
- This bacterial enzyme is involved in the modification of secondary
bile acids to form 3beta-bile acids (also known as iso-bile acids)
via a 3-oxo intermediate.
- The enzyme catalyzes a reversible reaction in vitro.
- Also acts on related bile acids.
- Cf. EC 1.1.1.52.
|
| Cross-references |
|---|
| BRENDA | 1.1.1.392 |
| EC2PDB | 1.1.1.392 |
| ExplorEnz | 1.1.1.392 |
| PRIAM enzyme-specific profiles | 1.1.1.392 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.392 |
| IUBMB Enzyme Nomenclature | 1.1.1.392 |
| IntEnz | 1.1.1.392 |
| MEDLINE | Find literature relating to 1.1.1.392 |
| MetaCyc | 1.1.1.392 |
| Rhea expert-curated reactions | 1.1.1.392 |
| UniProtKB/Swiss-Prot |
|
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