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ENZYME entry: EC 1.1.1.392
Accepted Name |
3alpha-hydroxycholanate dehydrogenase (NADP(+)).
|
Alternative Name(s) |
alpha-hydroxy-cholanate dehydrogenase. |
Reaction catalysed |
lithocholate + NADP(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADPH |
Comment(s) |
- This bacterial enzyme is involved in the modification of secondary
bile acids to form 3beta-bile acids (also known as iso-bile acids)
via a 3-oxo intermediate.
- The enzyme catalyzes a reversible reaction in vitro.
- Also acts on related bile acids.
- Cf. EC 1.1.1.52.
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Cross-references |
BRENDA | 1.1.1.392 |
EC2PDB | 1.1.1.392 |
ExplorEnz | 1.1.1.392 |
PRIAM enzyme-specific profiles | 1.1.1.392 |
KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.392 |
IUBMB Enzyme Nomenclature | 1.1.1.392 |
IntEnz | 1.1.1.392 |
MEDLINE | Find literature relating to 1.1.1.392 |
MetaCyc | 1.1.1.392 |
Rhea expert-curated reactions | 1.1.1.392 |
UniProtKB/Swiss-Prot |
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