Home  |  Contact

ENZYME entry: EC 1.1.1.41

Accepted Name
isocitrate dehydrogenase (NAD(+)).
Alternative Name(s)
beta-ketoglutaric-isocitric carboxylase.
IDH.
isocitrate dehydrogenase (NAD).
isocitric acid dehydrogenase.
isocitric dehydrogenase.
NAD dependent isocitrate dehydrogenase.
NAD isocitrate dehydrogenase.
NAD isocitric dehydrogenase.
NAD-linked isocitrate dehydrogenase.
NAD-specific isocitrate dehydrogenase.
nicotinamide adenine dinucleotide isocitrate dehydrogenase.
Reaction catalysed
D-threo-isocitrate + NAD(+) <=> 2-oxoglutarate + CO2 + NADH
Comment(s)
  • Unlike EC 1.1.1.42, oxalosuccinate cannot be used as a substrate.
  • In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm.
  • The enzyme from some species can also use NADP(+) but much more slowly.
Cross-references
BRENDA1.1.1.41
EC2PDB1.1.1.41
ExplorEnz1.1.1.41
PRIAM enzyme-specific profiles1.1.1.41
KEGG Ligand Database for Enzyme Nomenclature1.1.1.41
IUBMB Enzyme Nomenclature1.1.1.41
IntEnz1.1.1.41
MEDLINEFind literature relating to 1.1.1.41
MetaCyc1.1.1.41
Rhea expert-curated reactions1.1.1.41
UniProtKB/Swiss-Prot
O13302, IDH1_AJECA;  O94229, IDH1_KLULA;  O13696, IDH1_SCHPO;  
P28834, IDH1_YEAST;  O94230, IDH2_KLULA;  Q9USP8, IDH2_SCHPO;  
P28241, IDH2_YEAST;  P41563, IDH3A_BOVIN;  Q93714, IDH3A_CAEEL;  
P54836, IDH3A_CANLF;  Q9VWH4, IDH3A_DROME;  P50213, IDH3A_HUMAN;  
Q28480, IDH3A_MACFA;  P86225, IDH3A_MESAU;  Q9D6R2, IDH3A_MOUSE;  
P56471, IDH3A_PIG;  Q5R678, IDH3A_PONAB;  Q99NA5, IDH3A_RAT;  
Q93353, IDH3B_CAEEL;  Q945K7, IDH5_ARATH;  Q8LG77, IDH6_ARATH;  
Q55BI2, IDHA_DICDI;  Q54B68, IDHB_DICDI;  A0A096P8D3, IDH_OSTTA;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-