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ENZYME

ENZYME entry: EC 1.1.1.41

Accepted Name
isocitrate dehydrogenase (NAD(+))
Alternative Name(s)
beta-ketoglutaric-isocitric carboxylase
IDH
isocitrate dehydrogenase (NAD)
isocitric acid dehydrogenase
isocitric dehydrogenase
NAD dependent isocitrate dehydrogenase
NAD isocitrate dehydrogenase
NAD isocitric dehydrogenase
NAD-linked isocitrate dehydrogenase
NAD-specific isocitrate dehydrogenase
nicotinamide adenine dinucleotide isocitrate dehydrogenase
Reaction catalysed
D-threo-isocitrate + NAD(+) <=> 2-oxoglutarate + CO2 + NADH
Comment(s)
  • Unlike EC 1.1.1.42, oxalosuccinate cannot be used as a substrate.
  • In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm.
  • The enzyme from some species can also use NADP(+) but much more slowly.
Cross-references
BRENDA1.1.1.41
EC2PDB1.1.1.41
ExplorEnz1.1.1.41
PRIAM enzyme-specific profiles1.1.1.41
KEGG Ligand Database for Enzyme Nomenclature1.1.1.41
IUBMB Enzyme Nomenclature1.1.1.41
IntEnz1.1.1.41
MEDLINEFind literature relating to 1.1.1.41
MetaCyc1.1.1.41
Rhea expert-curated reactions1.1.1.41
UniProtKB/Swiss-Prot
O13302, IDH1_AJECAO94229, IDH1_KLULAB7G620, IDH1_PHATC
O13696, IDH1_SCHPOP28834, IDH1_YEASTO94230, IDH2_KLULA
Q9USP8, IDH2_SCHPOP28241, IDH2_YEASTP41563, IDH3A_BOVIN
Q93714, IDH3A_CAEELP54836, IDH3A_CANLFQ9VWH4, IDH3A_DROME
P50213, IDH3A_HUMANQ28480, IDH3A_MACFAP86225, IDH3A_MESAU
Q9D6R2, IDH3A_MOUSEP56471, IDH3A_PIGQ5R678, IDH3A_PONAB
Q99NA5, IDH3A_RATQ93353, IDH3B_CAEELQ945K7, IDH5_ARATH
Q8LG77, IDH6_ARATHQ55BI2, IDHA_DICDIQ54B68, IDHB_DICDI
A0A096P8D3, IDH_OSTTA

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