ENZYME entry: EC 1.1.1.41

Accepted Name
Isocitrate dehydrogenase (NAD(+)).
Alternative Name(s)
Beta-ketoglutaric-isocitric carboxylase.
IDH.
Isocitrate dehydrogenase (NAD).
Isocitric acid dehydrogenase.
Isocitric dehydrogenase.
NAD dependent isocitrate dehydrogenase.
NAD isocitrate dehydrogenase.
NAD isocitric dehydrogenase.
NAD-linked isocitrate dehydrogenase.
NAD-specific isocitrate dehydrogenase.
Nicotinamide adenine dinucleotide isocitrate dehydrogenase.
Reaction catalysed
Isocitrate + NAD(+) <=> 2-oxoglutarate + CO(2) + NADH
Cofactor(s)
Mn(2+) or Mg(2+).
Comment(s)
  • Unlike EC 1.1.1.42, oxalosuccinate cannot be used as a substrate.
  • In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm.
  • The enzyme from some species can also use NADP(+) but much more slowly.
Cross-references
PROSITEPDOC00389
BRENDA1.1.1.41
EC2PDB1.1.1.41
ExplorEnz1.1.1.41
PRIAM enzyme-specific profiles1.1.1.41
KEGG Ligand Database for Enzyme Nomenclature1.1.1.41
IUBMB Enzyme Nomenclature1.1.1.41
IntEnz1.1.1.41
MEDLINEFind literature relating to 1.1.1.41
MetaCyc1.1.1.41
UniProtKB/Swiss-Prot
O13302, IDH1_AJECA;  Q8LFC0, IDH1_ARATH;  O94229, IDH1_KLULA;  
O13696, IDH1_SCHPO;  P28834, IDH1_YEAST;  P93032, IDH2_ARATH;  
O94230, IDH2_KLULA;  Q9USP8, IDH2_SCHPO;  P28241, IDH2_YEAST;  
P41563, IDH3A_BOVIN;  Q93714, IDH3A_CAEEL;  P54836, IDH3A_CANLF;  
Q9VWH4, IDH3A_DROME;  P50213, IDH3A_HUMAN;  Q28480, IDH3A_MACFA;  
P86225, IDH3A_MESAU;  Q9D6R2, IDH3A_MOUSE;  P56471, IDH3A_PIG;  
Q5R678, IDH3A_PONAB;  Q99NA5, IDH3A_RAT;  Q93353, IDH3B_CAEEL;  
O81796, IDH3_ARATH;  Q945K7, IDH5_ARATH;  Q8LG77, IDH6_ARATH;  
Q55BI2, IDHA_DICDI;  Q54B68, IDHB_DICDI;  

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