| Accepted Name |
|---|
| Isocitrate dehydrogenase (NADP(+)).
|
| Alternative Name(s) |
|---|
| Dual-cofactor-specific isocitrate dehydrogenase. |
| IDH. |
| IDP. |
| Isocitrate (NADP) dehydrogenase. |
| Isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase. |
| Isocitrate dehydrogenase (NADP). |
| Isocitrate dehydrogenase (NADP-dependent). |
| NADP isocitric dehydrogenase. |
| NADP(+)-ICDH. |
| NADP(+)-IDH. |
| NADP(+)-linked isocitrate dehydrogenase. |
| NADP-dependent isocitrate dehydrogenase. |
| NADP-dependent isocitric dehydrogenase. |
| NADP-linked isocitrate dehydrogenase. |
| NADP-specific isocitrate dehydrogenase. |
| Oxalosuccinate decarboxylase. |
| Oxalsuccinic decarboxylase. |
| Triphosphopyridine nucleotide-linked isocitrate dehydrogenase-
oxalosuccinate carboxylase. |
| Reaction catalysed |
|---|
| Isocitrate + NADP(+) <=> 2-oxoglutarate + CO(2) + NADPH |
| Cofactor(s) |
|---|
| Mn(2+) or Mg(2+).
|
| Comment(s) |
|---|
- Unlike EC 1.1.1.41, oxalosuccinate can be used as a substrate.
- In eukaryotes, isocitrate dehydrogenase exists in two forms: an
NAD(+)-linked enzyme found only in mitochondria and displaying
allosteric properties, and a non-allosteric, NADP(+)-linked enzyme
that is found in both mitochondria and cytoplasm.
- The enzyme from some species can also use NAD(+) but much more
slowly.
|
| Cross-references |
|---|
| PROSITE | PDOC00389 |
| BRENDA | 1.1.1.42 |
| EC2PDB | 1.1.1.42 |
| ExplorEnz | 1.1.1.42 |
| PRIAM enzyme-specific profiles | 1.1.1.42 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.42 |
| IUBMB Enzyme Nomenclature | 1.1.1.42 |
| IntEnz | 1.1.1.42 |
| MEDLINE | Find literature relating to 1.1.1.42 |
| MetaCyc | 1.1.1.42 |
| UniProtKB/Swiss-Prot |
| Q9SRZ6, ICDHC_ARATH; | Q8LPJ5, ICDHP_ARATH; | Q9SLK0, ICDHX_ARATH; |
| O13285, IDH1_CANTR; | P41560, IDH1_COLMA; | O13294, IDH2_CANTR; |
| P41561, IDH2_COLMA; | Q9XSG3, IDHC_BOVIN; | Q75JR3, IDHC_DICDI; |
| O75874, IDHC_HUMAN; | Q9Z2K9, IDHC_MICME; | Q9Z2K8, IDHC_MICOH; |
| O88844, IDHC_MOUSE; | P83726, IDHC_NAEFO; | P20304, IDHC_PIG; |
| Q5R9C5, IDHC_PONAB; | P41562, IDHC_RAT; | Q6XUZ5, IDHC_SHEEP; |
| P50217, IDHC_SOLTU; | Q06197, IDHC_SOYBN; | P50218, IDHC_TOBAC; |
| P41939, IDHC_YEAST; | P53982, IDHH_YEAST; | P79089, IDHP_ASPNG; |
| Q04467, IDHP_BOVIN; | Q75JR2, IDHP_DICDI; | P48735, IDHP_HUMAN; |
| Q4R502, IDHP_MACFA; | Q40345, IDHP_MEDSA; | P54071, IDHP_MOUSE; |
| P33198, IDHP_PIG; | P56574, IDHP_RAT; | O14254, IDHP_SCHPO; |
| P21954, IDHP_YEAST; | O67480, IDH_AQUAE; | O29610, IDH_ARCFU; |
| P16100, IDH_AZOVI; | P39126, IDH_BACSU; | P96318, IDH_CALNO; |
| Q8RQL9, IDH_COREF; | P50216, IDH_CORGL; | Q9ZH99, IDH_COXBU; |
| P08200, IDH_ECOLI; | D4GU92, IDH_HALVD; | Q9ZN36, IDH_HELPJ; |
| P56063, IDH_HELPY; | P65098, IDH_MYCBO; | P9WKL0, IDH_MYCTO; |
| P9WKL1, IDH_MYCTU; | P50214, IDH_NOSS1; | Q02NB5, IDH_PSEAB; |
| Q1RJU4, IDH_RICBR; | Q92IR7, IDH_RICCN; | Q4UKR1, IDH_RICFE; |
| Q9ZDR0, IDH_RICPR; | Q68XA5, IDH_RICTY; | P50215, IDH_SPHYA; |
| Q5HF79, IDH_STAAC; | P65099, IDH_STAAM; | P99167, IDH_STAAN; |
| Q6GG12, IDH_STAAR; | Q6G8N2, IDH_STAAS; | Q8NW61, IDH_STAAW; |
| Q5HNL1, IDH_STAEQ; | Q8CNX4, IDH_STAES; | Q59940, IDH_STRMU; |
| Q59985, IDH_STRSL; | P80046, IDH_SYNY3; | P33197, IDH_THET8; |
|