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ENZYME

ENZYME entry: EC 1.1.1.42

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.42
Accepted Name
isocitrate dehydrogenase (NADP(+))
Alternative Name(s)
dual-cofactor-specific isocitrate dehydrogenase
IDH
IDP
isocitrate (NADP) dehydrogenase
isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase
isocitrate dehydrogenase (NADP)
isocitrate dehydrogenase (NADP-dependent)
NADP(+)-ICDH
NADP(+)-IDH
NADP(+)-linked isocitrate dehydrogenase
NADP-dependent isocitrate dehydrogenase
NADP-dependent isocitric dehydrogenase
NADP isocitric dehydrogenase
NADP-linked isocitrate dehydrogenase
NADP-specific isocitrate dehydrogenase
oxalosuccinate decarboxylase
oxalsuccinic decarboxylase
triphosphopyridine nucleotide-linked isocitrate dehydrogenase- oxalosuccinate carboxylase
Reaction catalysed
D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH
Comment(s)
  • Unlike EC 1.1.1.41, oxalosuccinate can be used as a substrate.
  • In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm.
  • The enzyme from some species can also use NAD(+) but much more slowly.
Cross-references
BRENDA1.1.1.42
EC2PDB1.1.1.42
ExplorEnz1.1.1.42
KEGG Ligand Database for Enzyme Nomenclature1.1.1.42
IUBMB Enzyme Nomenclature1.1.1.42
MEDLINEFind literature relating to 1.1.1.42
MetaCyc1.1.1.42
Rhea expert-curated reactions1.1.1.42
UniProtKB/Swiss-Prot
Q9SRZ6, ICDHC_ARATHQ8LPJ5, ICDHP_ARATHQ9SLK0, ICDHX_ARATH
O13285, IDH1_CANTRP41560, IDH1_COLMAP65098, IDH1_MYCBO
P9WKL0, IDH1_MYCTOP9WKL1, IDH1_MYCTUA0A5A4WIX0, IDH1_PSYS3
O13294, IDH2_CANTRP41561, IDH2_COLMAO53611, IDH2_MYCTU
A0A5A4WIZ7, IDH2_PSYS3Q9XSG3, IDHC_BOVINQ75JR3, IDHC_DICDI
O75874, IDHC_HUMANQ9Z2K9, IDHC_MICMEQ9Z2K8, IDHC_MICOH
O88844, IDHC_MOUSEP83726, IDHC_NAEFOP20304, IDHC_PIG
Q5R9C5, IDHC_PONABP41562, IDHC_RATQ6XUZ5, IDHC_SHEEP
P50217, IDHC_SOLTUQ06197, IDHC_SOYBNP50218, IDHC_TOBAC
P41939, IDHC_YEASTP53982, IDHH_YEASTP79089, IDHP_ASPNG
Q04467, IDHP_BOVINQ75JR2, IDHP_DICDIP48735, IDHP_HUMAN
Q4R502, IDHP_MACFAQ40345, IDHP_MEDSAP54071, IDHP_MOUSE
P33198, IDHP_PIGP56574, IDHP_RATO14254, IDHP_SCHPO
P21954, IDHP_YEASTO67480, IDH_AQUAEO29610, IDH_ARCFU
P16100, IDH_AZOVIP39126, IDH_BACSUP96318, IDH_CALNO
Q8RQL9, IDH_COREFP50216, IDH_CORGLQ9ZH99, IDH_COXBU
P08200, IDH_ECOLID4GU92, IDH_HALVDQ9ZN36, IDH_HELPJ
P56063, IDH_HELPYP50214, IDH_NOSS1Q02NB5, IDH_PSEAB
Q1RJU4, IDH_RICBRQ92IR7, IDH_RICCNQ4UKR1, IDH_RICFE
Q9ZDR0, IDH_RICPRQ68XA5, IDH_RICTYP50215, IDH_SPHYA
Q5HF79, IDH_STAACP65099, IDH_STAAMP99167, IDH_STAAN
Q6GG12, IDH_STAARQ6G8N2, IDH_STAASQ8NW61, IDH_STAAW
Q5HNL1, IDH_STAEQQ8CNX4, IDH_STAESQ59940, IDH_STRMU
Q59985, IDH_STRSLP80046, IDH_SYNY3P33197, IDH_THET8

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