ENZYME entry: EC 1.1.1.42

Accepted Name

isocitrate dehydrogenase (NADP(+))

Alternative Name(s)

dual-cofactor-specific isocitrate dehydrogenase

IDH

IDP

isocitrate (NADP) dehydrogenase

isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase

isocitrate dehydrogenase (NADP)

isocitrate dehydrogenase (NADP-dependent)

NADP(+)-ICDH

NADP(+)-IDH

NADP(+)-linked isocitrate dehydrogenase

NADP-dependent isocitrate dehydrogenase

NADP-dependent isocitric dehydrogenase

NADP isocitric dehydrogenase

NADP-linked isocitrate dehydrogenase

NADP-specific isocitrate dehydrogenase

oxalosuccinate decarboxylase

oxalsuccinic decarboxylase

triphosphopyridine nucleotide-linked isocitrate dehydrogenase- oxalosuccinate carboxylase

Reaction catalysed

D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH

Comment(s)

Unlike EC 1.1.1.41, oxalosuccinate can be used as a substrate.
In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm.
The enzyme from some species can also use NAD(+) but much more slowly.

Cross-references

BRENDA

1.1.1.42

EC2PDB

1.1.1.42

ExplorEnz

1.1.1.42

PRIAM enzyme-specific profiles

1.1.1.42

KEGG Ligand Database for Enzyme Nomenclature

1.1.1.42

IUBMB Enzyme Nomenclature

1.1.1.42

IntEnz

1.1.1.42

MEDLINE

Find literature relating to 1.1.1.42

MetaCyc

1.1.1.42

Rhea expert-curated reactions

1.1.1.42

UniProtKB/Swiss-Prot

Q9SRZ6, ICDHC_ARATH	Q8LPJ5, ICDHP_ARATH	Q9SLK0, ICDHX_ARATH
O13285, IDH1_CANTR	P41560, IDH1_COLMA	O13294, IDH2_CANTR
P41561, IDH2_COLMA	Q9XSG3, IDHC_BOVIN	Q75JR3, IDHC_DICDI
O75874, IDHC_HUMAN	Q9Z2K9, IDHC_MICME	Q9Z2K8, IDHC_MICOH
O88844, IDHC_MOUSE	P83726, IDHC_NAEFO	P20304, IDHC_PIG
Q5R9C5, IDHC_PONAB	P41562, IDHC_RAT	Q6XUZ5, IDHC_SHEEP
P50217, IDHC_SOLTU	Q06197, IDHC_SOYBN	P50218, IDHC_TOBAC
P41939, IDHC_YEAST	P53982, IDHH_YEAST	P79089, IDHP_ASPNG
Q04467, IDHP_BOVIN	Q75JR2, IDHP_DICDI	P48735, IDHP_HUMAN
Q4R502, IDHP_MACFA	Q40345, IDHP_MEDSA	P54071, IDHP_MOUSE
P33198, IDHP_PIG	P56574, IDHP_RAT	O14254, IDHP_SCHPO
P21954, IDHP_YEAST	O67480, IDH_AQUAE	O29610, IDH_ARCFU
P16100, IDH_AZOVI	P39126, IDH_BACSU	P96318, IDH_CALNO
Q8RQL9, IDH_COREF	P50216, IDH_CORGL	Q9ZH99, IDH_COXBU
P08200, IDH_ECOLI	D4GU92, IDH_HALVD	Q9ZN36, IDH_HELPJ
P56063, IDH_HELPY	P65098, IDH_MYCBO	P9WKL0, IDH_MYCTO
P9WKL1, IDH_MYCTU	P50214, IDH_NOSS1	Q02NB5, IDH_PSEAB
Q1RJU4, IDH_RICBR	Q92IR7, IDH_RICCN	Q4UKR1, IDH_RICFE
Q9ZDR0, IDH_RICPR	Q68XA5, IDH_RICTY	P50215, IDH_SPHYA
Q5HF79, IDH_STAAC	P65099, IDH_STAAM	P99167, IDH_STAAN
Q6GG12, IDH_STAAR	Q6G8N2, IDH_STAAS	Q8NW61, IDH_STAAW
Q5HNL1, IDH_STAEQ	Q8CNX4, IDH_STAES	Q59940, IDH_STRMU
Q59985, IDH_STRSL	P80046, IDH_SYNY3	P33197, IDH_THET8

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