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ENZYME entry: EC 1.1.1.413

Accepted Name
A-factor type gamma-butyrolactone 1'-reductase (1S-forming).
Reaction catalysed
a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) <=> a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH
Comment(s)
The enzyme, which is found in bacteria that produce virginiae- butanolide (VB) type gamma-butyrolactone autoregulators, reduces its substrate stereospecifically, forming a hydroxyl group in the (S) configuration.
Cross-references
BRENDA1.1.1.413
EC2PDB1.1.1.413
ExplorEnz1.1.1.413
PRIAM enzyme-specific profiles1.1.1.413
KEGG Ligand Database for Enzyme Nomenclature1.1.1.413
IUBMB Enzyme Nomenclature1.1.1.413
IntEnz1.1.1.413
MEDLINEFind literature relating to 1.1.1.413
MetaCyc1.1.1.413
Rhea expert-curated reactions1.1.1.413
UniProtKB/Swiss-Prot
Q9LBV3, BARS1_STRVG

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