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ENZYME

ENZYME entry: EC 1.1.1.423

Accepted Name
(1R,2S)-ephedrine 1-dehydrogenase
Alternative Name(s)
ephedrine dehydrogenase
Reaction catalysed
(1R,2S)-ephedrine + NAD(+) <=> (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH
Comment(s)
  • The enzyme, characterized from the bacterium Arthrobacter sp. TS-15, acts on a broad range of different aryl-alkyl ketones, such as haloketones, ketoamines, diketones, and ketoesters.
  • It exhibits a strict enantioselectivity and accepts various types of aryl groups including phenyl-, pyridyl-, thienyl-, and furyl-rings, but the presence of an aromatic ring is essential for the activity.
  • In addition, the presence of a functional group on the alkyl chain, such as an amine, a halogen, or a ketone, is also crucial.
  • When acting on diketones, it catalyzes the reduction of only the keto group closest to the ring, with no further reduction to the diol. cf. EC 1.1.1.422 and EC 1.5.1.18.
Cross-references
BRENDA1.1.1.423
EC2PDB1.1.1.423
ExplorEnz1.1.1.423
PRIAM enzyme-specific profiles1.1.1.423
KEGG Ligand Database for Enzyme Nomenclature1.1.1.423
IUBMB Enzyme Nomenclature1.1.1.423
IntEnz1.1.1.423
MEDLINEFind literature relating to 1.1.1.423
MetaCyc1.1.1.423
Rhea expert-curated reactions1.1.1.423

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
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