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ENZYME entry: EC 1.1.1.423

Accepted Name
(1R,2S)-ephedrine 1-dehydrogenase.
Alternative Name(s)
Ephedrine dehydrogenase.
Reaction catalysed
(-)-(1R,2S)-ephedrine + NAD(+) <=> (S)-2-(methylamino)-1-phenylpropan-1-one + NADH
Comment(s)
  • The enzyme, characterized from the bacterium Arthrobacter sp. TS-15, acts on a broad range of different aryl-alkyl ketones, such as haloketones, ketoamines, diketones, and ketoesters.
  • It exhibits a strict enantioselectivity and accepts various types of aryl groups including phenyl-, pyridyl-, thienyl-, and furyl-rings, but the presence of an aromatic ring is essential for the activity.
  • In addition, the presence of a functional group on the alkyl chain, such as an amine, a halogen, or a ketone, is also crucial.
  • When acting on diketones, it catalyzes the reduction of only the keto group closest to the ring, with no further reduction to the diol.
  • Cf. EC 1.1.1.422 and EC 1.5.1.18.
Cross-references
BRENDA1.1.1.423
EC2PDB1.1.1.423
ExplorEnz1.1.1.423
PRIAM enzyme-specific profiles1.1.1.423
KEGG Ligand Database for Enzyme Nomenclature1.1.1.423
IUBMB Enzyme Nomenclature1.1.1.423
IntEnz1.1.1.423
MEDLINEFind literature relating to 1.1.1.423
MetaCyc1.1.1.423
Rhea expert-curated reactions1.1.1.423

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