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ENZYME entry: EC 1.1.1.422
| Accepted Name |
|---|
| pseudoephedrine dehydrogenase.
|
| Reaction catalysed |
|---|
| (1S,2S)-pseudoephedrine + NAD(+) <=> (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH |
| Comment(s) |
|---|
- The enzyme, characterized from the bacterium Arthrobacter sp. TS-15,
acts on a broad range of different aryl-alkyl ketones, such as
haloketones, ketoamines, diketones, and ketoesters.
- It accepts various types of aryl groups including phenyl-, pyridyl-,
thienyl-, and furyl-rings, but the presence of an aromatic ring is
essential for the activity.
- In addition, the presence of a functional group on the alkyl chain,
such as an amine, a halogen, or a ketone, is also crucial.
- The enzyme exhibits a strict anti-Prelog enantioselectivity.
- When acting on diketones, it catalyzes the reduction of only the keto
group closest to the ring, with no further reduction to the diol.
- Cf. EC 1.1.1.423.
|
| Cross-references |
|---|
| BRENDA | 1.1.1.422 |
| EC2PDB | 1.1.1.422 |
| ExplorEnz | 1.1.1.422 |
| PRIAM enzyme-specific profiles | 1.1.1.422 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.422 |
| IUBMB Enzyme Nomenclature | 1.1.1.422 |
| IntEnz | 1.1.1.422 |
| MEDLINE | Find literature relating to 1.1.1.422 |
| MetaCyc | 1.1.1.422 |
| Rhea expert-curated reactions | 1.1.1.422 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-