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ENZYME entry: EC 1.1.1.422

Accepted Name
Pseudoephedrine dehydrogenase.
Reaction catalysed
(+)-(1S,2S)-pseudoephedrine + NAD(+) <=> (S)-2-methylamino-1-phenylpropan-1-one + NADH
Comment(s)
  • The enzyme, characterized from the bacterium Arthrobacter sp. TS-15, acts on a broad range of different aryl-alkyl ketones, such as haloketones, ketoamines, diketones, and ketoesters.
  • It accepts various types of aryl groups including phenyl-, pyridyl-, thienyl-, and furyl-rings, but the presence of an aromatic ring is essential for the activity.
  • In addition, the presence of a functional group on the alkyl chain, such as an amine, a halogen, or a ketone, is also crucial.
  • The enzyme exhibits a strict anti-Prelog enantioselectivity.
  • When acting on diketones, it catalyzes the reduction of only the keto group closest to the ring, with no further reduction to the diol.
  • Cf. EC 1.1.1.423.
Cross-references
BRENDA1.1.1.422
EC2PDB1.1.1.422
ExplorEnz1.1.1.422
PRIAM enzyme-specific profiles1.1.1.422
KEGG Ligand Database for Enzyme Nomenclature1.1.1.422
IUBMB Enzyme Nomenclature1.1.1.422
IntEnz1.1.1.422
MEDLINEFind literature relating to 1.1.1.422
MetaCyc1.1.1.422
Rhea expert-curated reactions1.1.1.422

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