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ENZYME

ENZYME entry: EC 1.1.1.428

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.428
Accepted Name
4-methylthio 2-oxobutanoate reductase (NADH)
Alternative Name(s)
4-methylthio 2-oxobutyrate reductase
4-methylthio 2-oxobutyric acid reductase
MTOB reductase
Reaction catalysed
(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+) = 4-methylsulfanyl-2-oxobutanoate + NADH + H(+)
Comment(s)
  • The substrate of this enzyme is formed as an intermediate during L-methionine salvage from S-methyl-5'-thioadenosine, which is formed during the biosynthesis of polyamines.
  • The human enzyme also functions as a transcriptional co-regulator that downregulates the expression of many tumor-suppressor genes, thus providing a link between gene repression and the methionine salvage pathway.
  • A similar, but NADP-specific, enzyme is involved in dimethylsulfoniopropanoate biosynthesis in algae and phytoplankton.
Cross-references
BRENDA1.1.1.428
EC2PDB1.1.1.428
ExplorEnz1.1.1.428
KEGG Ligand Database for Enzyme Nomenclature1.1.1.428
IUBMB Enzyme Nomenclature1.1.1.428
MEDLINEFind literature relating to 1.1.1.428
MetaCyc1.1.1.428
Rhea expert-curated reactions1.1.1.428

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-