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ENZYME entry: EC 1.1.1.49

Accepted Name
Glucose-6-phosphate dehydrogenase (NADP(+)).
Alternative Name(s)
G6PD.
G6PDH.
Glucose-6-phosphate 1-dehydrogenase.
Glucose-6-phosphate dehydrogenase.
GPD.
Reaction catalysed
D-glucose 6-phosphate + NADP(+) <=> 6-phospho-D-glucono-1,5-lactone + NADPH
Comment(s)
  • The enzyme catalyzes a step of the pentose phosphate pathway.
  • The enzyme is specific for NADP(+), cf. EC 1.1.1.363 and EC 1.1.1.388.
Cross-references
PROSITEPDOC00067
BRENDA1.1.1.49
EC2PDB1.1.1.49
ExplorEnz1.1.1.49
PRIAM enzyme-specific profiles1.1.1.49
KEGG Ligand Database for Enzyme Nomenclature1.1.1.49
IUBMB Enzyme Nomenclature1.1.1.49
IntEnz1.1.1.49
MEDLINEFind literature relating to 1.1.1.49
MetaCyc1.1.1.49
Rhea expert-curated reactions1.1.1.49
UniProtKB/Swiss-Prot
Q43727, G6PD1_ARATH;  Q00612, G6PD1_MOUSE;  P0A587, G6PD1_MYCBO;  
P9WN70, G6PD1_MYCTO;  P9WN71, G6PD1_MYCTU;  Q9FY99, G6PD2_ARATH;  
P97324, G6PD2_MOUSE;  P0A585, G6PD2_MYCBO;  P9WN72, G6PD2_MYCTO;  
P9WN73, G6PD2_MYCTU;  O59812, G6PD2_SCHPO;  Q8L743, G6PD3_ARATH;  
O14137, G6PD3_SCHPO;  Q9LK23, G6PD5_ARATH;  Q9FJI5, G6PD6_ARATH;  
Q43839, G6PDC_SOLTU;  O24357, G6PDC_SPIOL;  Q43793, G6PDC_TOBAC;  
P77809, G6PD_AGGAC;  P48826, G6PD_ASPNG;  P54547, G6PD_BACSU;  
O51581, G6PD_BORBU;  Q7YS37, G6PD_BOSIN;  P57405, G6PD_BUCAI;  
Q8K9M2, G6PD_BUCAP;  Q89AI7, G6PD_BUCBP;  Q27464, G6PD_CAEEL;  
P41571, G6PD_CERCA;  Q9PKK8, G6PD_CHLMU;  Q9Z8U6, G6PD_CHLPN;  
O84188, G6PD_CHLTR;  O55044, G6PD_CRIGR;  Q23711, G6PD_CULPI;  
P11410, G6PD_CYBJA;  P37986, G6PD_DICD3;  Q557D2, G6PD_DICDI;  
P15588, G6PD_DIDVI;  P12646, G6PD_DROME;  Q24625, G6PD_DROSI;  
Q27638, G6PD_DROYA;  Q8XCJ6, G6PD_ECO57;  P0AC54, G6PD_ECOL6;  
P0AC53, G6PD_ECOLI;  P41764, G6PD_EMENI;  Q8SR89, G6PD_ENCCU;  
Q5FUK8, G6PD_GLUOX;  P44311, G6PD_HAEIN;  Q9ZKB2, G6PD_HELPJ;  
P56110, G6PD_HELPY;  P11413, G6PD_HUMAN;  Q25019, G6PD_HYACE;  
P48828, G6PD_KLULA;  Q29492, G6PD_MACRO;  P80619, G6PD_MAIZE;  
Q42919, G6PD_MEDSA;  A0QP90, G6PD_MYCS2;  P48848, G6PD_NOSP7;  
P48992, G6PD_NOSS1;  P05370, G6PD_RAT;  Q9Z3S2, G6PD_RHIME;  
Q25537, G6PD_SARBU;  O00091, G6PD_SCHPO;  P37830, G6PD_SOLTU;  
O54537, G6PD_STRPN;  P29686, G6PD_SYNE7;  P73411, G6PD_SYNY3;  
P54996, G6PD_TAKRU;  Q9X0N9, G6PD_THEMA;  O83491, G6PD_TREPA;  
P11412, G6PD_YEAST;  P21907, G6PD_ZYMMO;  Q8IKU0, GLUPH_PLAF7;  

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