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ENZYME entry: EC 1.1.1.53

Accepted Name
3-alpha(or 20-beta)-hydroxysteroid dehydrogenase.
Alternative Name(s)
(R)-20-hydroxysteroid dehydrogenase.
Cortisone reductase.
Reaction catalysed
Androstan-3-alpha,17-beta-diol + NAD(+) <=> 17-beta-hydroxyandrostan-3-one + NADH
Comment(s)
The 3-alpha-hydroxy group or 20-beta-hydroxy group of pregnane and androstane steroids can act as donor.
Cross-references
PROSITEPDOC00060
BRENDA1.1.1.53
EC2PDB1.1.1.53
ExplorEnz1.1.1.53
PRIAM enzyme-specific profiles1.1.1.53
KEGG Ligand Database for Enzyme Nomenclature1.1.1.53
IUBMB Enzyme Nomenclature1.1.1.53
IntEnz1.1.1.53
MEDLINEFind literature relating to 1.1.1.53
MetaCyc1.1.1.53
Rhea expert-curated reactions1.1.1.53
UniProtKB/Swiss-Prot
Q04828, AK1C1_HUMAN;  Q95JH7, AK1C1_MACFA;  Q95JH6, AK1C1_MACFU;  
Q5REQ0, AK1C1_PONAB;  P52895, AK1C2_HUMAN;  P42330, AK1C3_HUMAN;  
Q5R7C9, AK1C3_PONAB;  P17516, AK1C4_HUMAN;  Q95JH5, AK1C4_MACFA;  
Q95JH4, AK1C4_MACFU;  Q8MI29, CBR1_MACFA;  Q8HYR6, DHRS9_BOVIN;  
Q9BPW9, DHRS9_HUMAN;  Q58NB6, DHRS9_MOUSE;  Q8VD48, DHRS9_RAT;  
Q3T001, H17B6_BOVIN;  O14756, H17B6_HUMAN;  Q9R092, H17B6_MOUSE;  
O54753, H17B6_RAT;  O02691, HCD2_BOVIN;  Q99714, HCD2_HUMAN;  
O08756, HCD2_MOUSE;  O70351, HCD2_RAT;  P69166, HSD_MYCBO;  
P9WGT0, HSD_MYCTO;  P9WGT1, HSD_MYCTU;  P19992, HSD_STREX;  
O75452, RDH16_HUMAN;  O54909, RDH16_MOUSE;  P50170, RDH16_RAT;  
Q27979, RDH5_BOVIN;  Q92781, RDH5_HUMAN;  O55240, RDH5_MOUSE;  

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