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ENZYME

ENZYME entry: EC 1.1.1.53

Accepted Name
3alpha(or 20beta)-hydroxysteroid dehydrogenase
Alternative Name(s)
(R)-20-hydroxysteroid dehydrogenase
cortisone reductase
Reaction catalysed
androstan-3alpha,17beta-diol + NAD(+) = 17beta-hydroxyandrostanone + H(+) + NADH
Comment(s)
The 3alpha-hydroxy group or 20beta-hydroxy group of pregnane and androstane steroids can act as donor.
Cross-references
BRENDA1.1.1.53
EC2PDB1.1.1.53
ExplorEnz1.1.1.53
PRIAM enzyme-specific profiles1.1.1.53
KEGG Ligand Database for Enzyme Nomenclature1.1.1.53
IUBMB Enzyme Nomenclature1.1.1.53
IntEnz1.1.1.53
MEDLINEFind literature relating to 1.1.1.53
MetaCyc1.1.1.53
Rhea expert-curated reactions1.1.1.53
UniProtKB/Swiss-Prot
Q04828, AK1C1_HUMANQ95JH7, AK1C1_MACFAQ95JH6, AK1C1_MACFU
Q5REQ0, AK1C1_PONABP52895, AK1C2_HUMANP42330, AK1C3_HUMAN
Q5R7C9, AK1C3_PONABP17516, AK1C4_HUMANQ95JH5, AK1C4_MACFA
Q95JH4, AK1C4_MACFUQ8HYR6, DHRS9_BOVINQ9BPW9, DHRS9_HUMAN
Q58NB6, DHRS9_MOUSEQ8VD48, DHRS9_RATQ3T001, H17B6_BOVIN
O14756, H17B6_HUMANQ9R092, H17B6_MOUSEO54753, H17B6_RAT
O02691, HCD2_BOVINO18404, HCD2_DROMEQ99714, HCD2_HUMAN
O08756, HCD2_MOUSEO70351, HCD2_RATP69166, HSD_MYCBO
P9WGT0, HSD_MYCTOP9WGT1, HSD_MYCTUP19992, HSD_STREX
O75452, RDH16_HUMANO54909, RDH16_MOUSEP50170, RDH16_RAT
Q27979, RDH5_BOVINQ92781, RDH5_HUMANO55240, RDH5_MOUSE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
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