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ENZYME

ENZYME entry: EC 1.1.1.95

Accepted Name
phosphoglycerate dehydrogenase
Alternative Name(s)
3-phosphoglycerate dehydrogenase
3-phosphoglyceric acid dehydrogenase
3PHP reductase
alphaKG reductase
alpha-phosphoglycerate dehydrogenase
D-3-phosphoglycerate dehydrogenase
glycerate-1,3-phosphate dehydrogenase
glycerate 3-phosphate dehydrogenase
PGDH
phosphoglycerate oxidoreductase
phosphoglyceric acid dehydrogenase
Reaction catalysed
(2R)-3-phosphoglycerate + NAD(+) <=> 3-phosphooxypyruvate + H(+) + NADH
Comment(s)
  • Catalyzes the first committed and rate-limiting step in the phosphoserine pathway of serine biosynthesis.
  • The reaction occurs predominantly in the direction of reduction.
  • The enzyme from the bacterium Escherichia coli also catalyzes the activity of EC 1.1.1.399.
Cross-references
BRENDA1.1.1.95
EC2PDB1.1.1.95
ExplorEnz1.1.1.95
PRIAM enzyme-specific profiles1.1.1.95
KEGG Ligand Database for Enzyme Nomenclature1.1.1.95
IUBMB Enzyme Nomenclature1.1.1.95
IntEnz1.1.1.95
MEDLINEFind literature relating to 1.1.1.95
MetaCyc1.1.1.95
Rhea expert-curated reactions1.1.1.95
UniProtKB/Swiss-Prot
P40510, SER33_YEASTO49485, SERA1_ARATHO04130, SERA2_ARATH
Q9LT69, SERA3_ARATHO29445, SERA_ARCFUP35136, SERA_BACSU
Q5EAD2, SERA_BOVINQ54UH8, SERA_DICDIP0A9T2, SERA_ECO57
P0A9T1, SERA_ECOL6P0A9T0, SERA_ECOLIP43885, SERA_HAEIN
O43175, SERA_HUMANQ60HD7, SERA_MACFAQ58424, SERA_METJA
O27051, SERA_METTHQ61753, SERA_MOUSEP0A545, SERA_MYCBO
O33116, SERA_MYCLEP9WNX2, SERA_MYCTOP9WNX3, SERA_MYCTU
A5A6P1, SERA_PANTRA5GFY8, SERA_PIGQ5R7M2, SERA_PONAB
O08651, SERA_RATP87228, SERA_SCHPOP0A9T3, SERA_SHIFL
P73821, SERA_SYNY3P40054, SERA_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
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