ENZYME entry: EC 1.1.1.399
Accepted Name |
2-oxoglutarate reductase.
|
Reaction catalysed |
(R)-2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + NADH |
Comment(s) |
- The enzyme catalyzes a reversible reaction.
- The enzyme from the bacterium Peptoniphilus asaccharolyticus is
specific for (R)-2-hydroxyglutarate.
- The SerA enzyme from Escherichia coli can also accept (S)-2-
hydroxyglutarate with a much higher Km, and also catalyzes the
activity of EC 1.1.1.95.
|
Cross-references |
BRENDA | 1.1.1.399 |
EC2PDB | 1.1.1.399 |
ExplorEnz | 1.1.1.399 |
PRIAM enzyme-specific profiles | 1.1.1.399 |
KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.399 |
IUBMB Enzyme Nomenclature | 1.1.1.399 |
IntEnz | 1.1.1.399 |
MEDLINE | Find literature relating to 1.1.1.399 |
MetaCyc | 1.1.1.399 |
UniProtKB/Swiss-Prot |
D2RJU7, HGDH_ACIFV; | P40510, SER33_YEAST; | P35136, SERA_BACSU; |
Q5EAD2, SERA_BOVIN; | Q54UH8, SERA_DICDI; | P0A9T2, SERA_ECO57; |
P0A9T1, SERA_ECOL6; | P0A9T0, SERA_ECOLI; | P43885, SERA_HAEIN; |
O43175, SERA_HUMAN; | Q60HD7, SERA_MACFA; | P0A545, SERA_MYCBO; |
O33116, SERA_MYCLE; | P9WNX2, SERA_MYCTO; | P9WNX3, SERA_MYCTU; |
A5A6P1, SERA_PANTR; | A5GFY8, SERA_PIG; | Q5R7M2, SERA_PONAB; |
P87228, SERA_SCHPO; | P0A9T3, SERA_SHIFL; | P73821, SERA_SYNY3; |
P40054, SERA_YEAST; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
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