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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.1.1.399

Accepted Name
2-oxoglutarate reductase.
Reaction catalysed
(R)-2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + NADH
Comment(s)
  • The enzyme catalyzes a reversible reaction.
  • The enzyme from the bacterium Peptoniphilus asaccharolyticus is specific for (R)-2-hydroxyglutarate.
  • The SerA enzyme from Escherichia coli can also accept (S)-2- hydroxyglutarate with a much higher Km, and also catalyzes the activity of EC 1.1.1.95.
Cross-references
BRENDA1.1.1.399
EC2PDB1.1.1.399
ExplorEnz1.1.1.399
PRIAM enzyme-specific profiles1.1.1.399
KEGG Ligand Database for Enzyme Nomenclature1.1.1.399
IUBMB Enzyme Nomenclature1.1.1.399
IntEnz1.1.1.399
MEDLINEFind literature relating to 1.1.1.399
MetaCyc1.1.1.399
UniProtKB/Swiss-Prot
D2RJU7, HGDH_ACIFV;  P40510, SER33_YEAST;  P35136, SERA_BACSU;  
Q5EAD2, SERA_BOVIN;  Q54UH8, SERA_DICDI;  P0A9T2, SERA_ECO57;  
P0A9T1, SERA_ECOL6;  P0A9T0, SERA_ECOLI;  P43885, SERA_HAEIN;  
O43175, SERA_HUMAN;  Q60HD7, SERA_MACFA;  P0A545, SERA_MYCBO;  
O33116, SERA_MYCLE;  P9WNX2, SERA_MYCTO;  P9WNX3, SERA_MYCTU;  
A5A6P1, SERA_PANTR;  A5GFY8, SERA_PIG;  Q5R7M2, SERA_PONAB;  
P87228, SERA_SCHPO;  P0A9T3, SERA_SHIFL;  P73821, SERA_SYNY3;  
P40054, SERA_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-