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ENZYME

ENZYME entry: EC 1.1.2.10

PURL: https://purl.expasy.org/enzyme/EC/1.1.2.10
Accepted Name
lanthanide-dependent methanol dehydrogenase
Alternative Name(s)
Ce(3+)-induced methanol dehydrogenase
cerium dependent MDH
La(3+)-dependent MDH
Reaction catalysed
2 Fe(III)-[cytochrome cL] + methanol = 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+)
Comment(s)
  • Isolated from the bacterium Methylacidiphilum fumariolicum and many Methylobacterium species.
  • Requires La(3+), Ce(3+), Pr(3+) or Nd(3+).
  • The higher lanthanides show decreasing activity with Sm(3+), Eu(3+) and Gd(3+).
  • The lanthanide is coordinated by the enzyme and pyrroloquinoline quinone.
  • Shows little activity with Ca(2+), the required cofactor of EC 1.1.2.7.
Cross-references
BRENDA1.1.2.10
EC2PDB1.1.2.10
ExplorEnz1.1.2.10
KEGG Ligand Database for Enzyme Nomenclature1.1.2.10
IUBMB Enzyme Nomenclature1.1.2.10
MEDLINEFind literature relating to 1.1.2.10
MetaCyc1.1.2.10
Rhea expert-curated reactions1.1.2.10
UniProtKB/Swiss-Prot
C5B120, XOXF1_METEAA0A3F2YLY8, XOXF_METBYI0JWN7, XOXF_METFB

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