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ENZYME

ENZYME entry: EC 1.1.5.3

Accepted Name
glycerol-3-phosphate dehydrogenase
Alternative Name(s)
FAD-dependent glycerol-3-phosphate dehydrogenase
flavin-linked glycerol-3-phosphate dehydrogenase
glycerol-3-phosphate CoQ reductase
glycerophosphate dehydrogenase
L-glycerophosphate dehydrogenase
sn-glycerol-3-phosphate dehydrogenase
Reaction catalysed
a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate
Comment(s)
  • An essential membrane enzyme, functioning at the central junction of glycolysis, respiration and phospholipid biosynthesis.
  • In bacteria, the enzyme is localized to the cytoplasmic membrane, while in eukaryotes it is tightly bound to the outer surface of the inner mitochondrial membrane.
  • In eukaryotes, this enzyme, together with the cytosolic enzyme EC 1.1.1.8 forms the glycerol-3-phosphate shuttle by which NADH produced in the cytosol, primarily from glycolysis, can be reoxidized to NAD(+) by the mitochondrial electron-transport chain.
  • This shuttle plays a critical role in transferring reducing equivalents from cytosolic NADH into the mitochondrial matrix.
  • Insect flight muscle uses only CoQ10 as the physiological quinone whereas hamster and rat mitochondria use mainly CoQ9.
  • The enzyme is activated by calcium.
  • Formerly EC 1.1.2.1 and EC 1.1.99.5.
Cross-references
BRENDA1.1.5.3
EC2PDB1.1.5.3
ExplorEnz1.1.5.3
PRIAM enzyme-specific profiles1.1.5.3
KEGG Ligand Database for Enzyme Nomenclature1.1.5.3
IUBMB Enzyme Nomenclature1.1.5.3
IntEnz1.1.5.3
MEDLINEFind literature relating to 1.1.5.3
MetaCyc1.1.5.3
Rhea expert-curated reactions1.1.5.3
UniProtKB/Swiss-Prot
D4GYI2, GLPA1_HALVDD4GQU6, GLPA2_HALVDP0A9C1, GLPA_ECO57
P0A9C0, GLPA_ECOLIP43799, GLPA_HAEINP0A9C2, GLPA_SHIFL
A3MZ98, GLPB_ACTP2B3H0P4, GLPB_ACTP7B0BTN3, GLPB_ACTPJ
A6VKT7, GLPB_ACTSZQ5E0X7, GLPB_ALIF1B5ET22, GLPB_ALIFM
A8ADX8, GLPB_CITK8A7ZP63, GLPB_ECO24B7UFQ3, GLPB_ECO27
B7MG07, GLPB_ECO45B7LAR0, GLPB_ECO55Q8XE13, GLPB_ECO57
B5YX30, GLPB_ECO5EB7NN59, GLPB_ECO7IB7MXS2, GLPB_ECO81
B7M5S7, GLPB_ECO8AC4ZU83, GLPB_ECOBWB1X8D6, GLPB_ECODH
A8A2A7, GLPB_ECOHSA1AD94, GLPB_ECOK1Q0TFK1, GLPB_ECOL5
Q8FFN4, GLPB_ECOL6B1IXU6, GLPB_ECOLCP13033, GLPB_ECOLI
B7N5K6, GLPB_ECOLUB6I7H1, GLPB_ECOSEB1LLJ4, GLPB_ECOSM
Q1R9H5, GLPB_ECOUTA4WCP1, GLPB_ENT38B7LM86, GLPB_ESCF3
B8F6F3, GLPB_GLAP5Q7VM49, GLPB_HAEDUQ4QMN2, GLPB_HAEI8
A5UE48, GLPB_HAEIEA5UHH2, GLPB_HAEIGP43800, GLPB_HAEIN
B0R6S4, GLPB_HALS3Q9HNS3, GLPB_HALSAQ0I239, GLPB_HISS1
B0UVX7, GLPB_HISS2B5XNY5, GLPB_KLEP3A6TBU4, GLPB_KLEP7
Q65R09, GLPB_MANSMQ9CL07, GLPB_PASMUQ6CZI7, GLPB_PECAS
C6DH98, GLPB_PECCPQ6LSE4, GLPB_PHOPRB5EYX0, GLPB_SALA4
A9MJD3, GLPB_SALARQ57M68, GLPB_SALCHB5FNS6, GLPB_SALDC
B5R258, GLPB_SALEPB5RCB0, GLPB_SALG2B4TBF2, GLPB_SALHS
B4SYV7, GLPB_SALNSQ5PI45, GLPB_SALPAA9N5C9, GLPB_SALPB
B5BCR1, GLPB_SALPKB4TPG8, GLPB_SALSVQ8Z553, GLPB_SALTI
Q8ZNG4, GLPB_SALTYB2TW33, GLPB_SHIB3Q31Z75, GLPB_SHIBS
Q32DU5, GLPB_SHIDSQ0T2N9, GLPB_SHIF8Q83ML0, GLPB_SHIFL
Q3YZW4, GLPB_SHISSA5EZR7, GLPB_VIBC3Q9KLJ6, GLPB_VIBCH
C3LW14, GLPB_VIBCMQ8D7Y4, GLPB_VIBVUQ7MF00, GLPB_VIBVY
A1JIB0, GLPB_YERE8Q1CBK6, GLPB_YERPAQ8ZAH6, GLPB_YERPE
Q1CNF8, GLPB_YERPNQ66FX5, GLPB_YERPSP64183, GLPD1_MYCBO
P9WN80, GLPD1_MYCTOP9WN81, GLPD1_MYCTUP64185, GLPD2_MYCBO
P9WN78, GLPD2_MYCTOP9WN79, GLPD2_MYCTUP18158, GLPD_BACSU
P13035, GLPD_ECOLIP53435, GLPD_MYCLEP52111, GLPD_PSEAE
O83004, GLPD_PSETOQ2FHD8, GLPD_STAA3Q2FYZ4, GLPD_STAA8
Q2YXR5, GLPD_STAABQ5HGD1, GLPD_STAACQ99UH2, GLPD_STAAM
Q7A5V7, GLPD_STAANQ6GHD4, GLPD_STAARQ6G9R2, GLPD_STAAS
Q7A105, GLPD_STAAWQ5HPP0, GLPD_STAEQQ8CPE6, GLPD_STAES
Q4L608, GLPD_STAHJQ49X94, GLPD_STAS1P74257, GLPD_SYNY3
Q8SR40, GPDH_ENCCUA6QLU1, GPDM_BOVINP90795, GPDM_CAEEL
Q54QC1, GPDM_DICDIP43304, GPDM_HUMANQ4R755, GPDM_MACFA
A7DZP8, GPDM_MESAUQ64521, GPDM_MOUSEP35571, GPDM_RAT
O14400, GPDM_SCHPOP32191, GPDM_YEASTQ9SS48, SDP6_ARATH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.5.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-