ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.1.99.28

Accepted Name

Glucose-fructose oxidoreductase.

Reaction catalysed

D-glucose + D-fructose <=> D-gluconolactone + D-glucitol

Comment(s)

D-mannose, D-xylose, D-galactose, 2-deoxy-D-glucose and L-arabinose will function as aldose substrates, but with low affinities.
The ketose substrate must be in the open-chain form.
The apparent affinity for fructose is low, because little of the fructose substrate is in the open-chain form.
Xylulose and glycerone (dihydroxyacetone) will replace fructose, but they are poor substrates.
The enzyme from Zymomonas mobilis contains tightly bound NADP(+).

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature