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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.1.99.28

Accepted Name
Glucose-fructose oxidoreductase.
Reaction catalysed
D-glucose + D-fructose <=> D-gluconolactone + D-glucitol
Comment(s)
  • D-mannose, D-xylose, D-galactose, 2-deoxy-D-glucose and L-arabinose will function as aldose substrates, but with low affinities.
  • The ketose substrate must be in the open-chain form.
  • The apparent affinity for fructose is low, because little of the fructose substrate is in the open-chain form.
  • Xylulose and glycerone (dihydroxyacetone) will replace fructose, but they are poor substrates.
  • The enzyme from Zymomonas mobilis contains tightly bound NADP(+).
Cross-references
BRENDA1.1.99.28
EC2PDB1.1.99.28
ExplorEnz1.1.99.28
PRIAM enzyme-specific profiles1.1.99.28
KEGG Ligand Database for Enzyme Nomenclature1.1.99.28
IUBMB Enzyme Nomenclature1.1.99.28
IntEnz1.1.99.28
MEDLINEFind literature relating to 1.1.99.28
MetaCyc1.1.99.28
UniProtKB/Swiss-Prot
Q07982, GFO_ZYMMO

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