A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.1.99.31
| Accepted Name |
|---|
| (S)-mandelate dehydrogenase.
|
| Alternative Name(s) |
|---|
| L(+)-mandelate dehydrogenase. |
| MDH. |
| Reaction catalysed |
|---|
| (S)-2-hydroxy-2-phenylacetate + acceptor <=> 2-oxo-2-phenylacetate + reduced acceptor |
| Comment(s) |
|---|
- While all enzymes of this family oxidize the (S)-enantiomer of an
alpha-hydroxy acid to an alpha-oxo acid, the ultimate oxidant
(oxygen, intramolecular heme or some other acceptor) depends on the
particular enzyme.
- Transfers the electron pair from FMNH(2) to a component of the
electron transport chain, most probably ubiquinone.
- It is part of a metabolic pathway in Pseudomonads that allows these
organisms to utilize mandelic acid, derivatized from the common soil
metabolite amygdalin, as the sole source of carbon and energy.
- Has a large active-site pocket and preferentially binds substrates
with longer sidechains, e.g. 2-hydroxyoctanoate rather than
2-hydroxybutyrate.
- It also prefers substrates that, like (S)-mandelate, have beta
unsaturation, e.g. (indol-3-yl)glycolate compared with (indol-3-
yl)lactate.
- Esters of mandelate, such as methyl (S)-mandelate, are also
substrates.
|
| Cross-references |
|---|
| PROSITE | PDOC00482 |
| BRENDA | 1.1.99.31 |
| EC2PDB | 1.1.99.31 |
| ExplorEnz | 1.1.99.31 |
| PRIAM enzyme-specific profiles | 1.1.99.31 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.99.31 |
| IUBMB Enzyme Nomenclature | 1.1.99.31 |
| IntEnz | 1.1.99.31 |
| MEDLINE | Find literature relating to 1.1.99.31 |
| MetaCyc | 1.1.99.31 |
| UniProtKB/Swiss-Prot |
|
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