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ENZYME entry: EC

Accepted Name
methanol dehydrogenase (nicotinoprotein).
Alternative Name(s)
NDMA-dependent methanol dehydrogenase.
nicotinoprotein methanol dehydrogenase.
Reaction catalysed
A + methanol <=> AH2 + formaldehyde
  • Nicotinoprotein methanol dehydrogenases have a tightly bound NADP+/NADPH cofactor that does not dissociate during the catalytic process.
  • Instead, the cofactor is regenerated by a second substrate or electron carrier.
  • While the in vivo electron acceptor is not known, N,N-dimethyl-4- nitrosoaniline (NDMA) can serve this function in vitro.
  • The enzyme has been detected in several Gram-positive methylotrophic bacteria, including Amycolatopsis methanolica, Rhodococcus rhodochrous and Rhodococcus erythropolis.
  • These enzymes are decameric, and possess a 5-fold symmetry.
  • Some of the enzymes can also dismutate formaldehyde to methanol and formate.
PRIAM enzyme-specific profiles1.1.99.37
KEGG Ligand Database for Enzyme Nomenclature1.1.99.37
IUBMB Enzyme Nomenclature1.1.99.37
MEDLINEFind literature relating to
Rhea expert-curated reactions1.1.99.37

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