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ENZYME entry: EC 1.1.99.37

Accepted Name
Methanol dehydrogenase (nicotinoprotein).
Alternative Name(s)
NDMA-dependent methanol dehydrogenase.
Nicotinoprotein methanol dehydrogenase.
Reaction catalysed
Methanol + acceptor <=> formaldehyde + reduced acceptor
Cofactor(s)
Mg(2+); Zn(2+).
Comment(s)
  • Nicotinoprotein methanol dehydrogenases have a tightly bound NADP+/NADPH cofactor that does not dissociate during the catalytic process.
  • Instead, the cofactor is regenerated by a second substrate or electron carrier.
  • While the in vivo electron acceptor is not known, N,N-dimethyl-4- nitrosoaniline (NDMA) can serve this function in vitro.
  • The enzyme has been detected in several Gram-positive methylotrophic bacteria, including Amycolatopsis methanolica, Rhodococcus rhodochrous and Rhodococcus erythropolis.
  • These enzymes are decameric, and possess a 5-fold symmetry.
  • Some of the enzymes can also dismutate formaldehyde to methanol and formate.
Cross-references
BRENDA1.1.99.37
EC2PDB1.1.99.37
ExplorEnz1.1.99.37
PRIAM enzyme-specific profiles1.1.99.37
KEGG Ligand Database for Enzyme Nomenclature1.1.99.37
IUBMB Enzyme Nomenclature1.1.99.37
IntEnz1.1.99.37
MEDLINEFind literature relating to 1.1.99.37
MetaCyc1.1.99.37
Rhea expert-curated reactions1.1.99.37
UniProtKB/Swiss-Prot
Q9RCG0, MNO_AMYME;  C5MRT8, MNO_MYCS8;  Q53062, MNO_RHOER;  

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