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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Methanol dehydrogenase (nicotinoprotein).
Alternative Name(s)
NDMA-dependent methanol dehydrogenase.
Nicotinoprotein methanol dehydrogenase.
Reaction catalysed
Methanol + acceptor <=> formaldehyde + reduced acceptor
Mg(2+); Zn(2+).
  • Nicotinoprotein methanol dehydrogenases have a tightly bound NADP+/NADPH cofactor that does not dissociate during the catalytic process.
  • Instead, the cofactor is regenerated by a second substrate or electron carrier.
  • While the in vivo electron acceptor is not known, N,N-dimethyl-4- nitrosoaniline (NDMA) can serve this function in vitro.
  • The enzyme has been detected in several Gram-positive methylotrophic bacteria, including Amycolatopsis methanolica, Rhodococcus rhodochrous and Rhodococcus erythropolis.
  • These enzymes are decameric, and possess a 5-fold symmetry.
  • Some of the enzymes can also dismutate formaldehyde to methanol and formate.
PRIAM enzyme-specific profiles1.1.99.37
KEGG Ligand Database for Enzyme Nomenclature1.1.99.37
IUBMB Enzyme Nomenclature1.1.99.37
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