Expasy logo

ENZYME

ENZYME entry: EC 1.1.99.37

PURL: https://purl.expasy.org/enzyme/EC/1.1.99.37
Accepted Name
methanol dehydrogenase (nicotinoprotein)
Alternative Name(s)
NDMA-dependent methanol dehydrogenase
nicotinoprotein methanol dehydrogenase
Reaction catalysed
methanol + A = formaldehyde + AH2
Comment(s)
  • Nicotinoprotein methanol dehydrogenases have a tightly bound NADP+/NADPH cofactor that does not dissociate during the catalytic process.
  • Instead, the cofactor is regenerated by a second substrate or electron carrier.
  • While the in vivo electron acceptor is not known, N,N-dimethyl-4- nitrosoaniline (NDMA) can serve this function in vitro.
  • The enzyme has been detected in several Gram-positive methylotrophic bacteria, including Amycolatopsis methanolica, Rhodococcus rhodochrous and Rhodococcus erythropolis.
  • These enzymes are decameric, and possess a 5-fold symmetry.
  • Some of the enzymes can also dismutate formaldehyde to methanol and formate.
Cross-references
BRENDA1.1.99.37
EC2PDB1.1.99.37
ExplorEnz1.1.99.37
KEGG Ligand Database for Enzyme Nomenclature1.1.99.37
IUBMB Enzyme Nomenclature1.1.99.37
MEDLINEFind literature relating to 1.1.99.37
MetaCyc1.1.99.37
Rhea expert-curated reactions1.1.99.37
UniProtKB/Swiss-Prot
Q9RCG0, MNO_AMYMEC5MRT8, MNO_MYCS8Q53062, MNO_RHOER

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-