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ENZYME entry: EC 1.1.99.39

Accepted Name
D-2-hydroxyglutarate dehydrogenase.
Reaction catalysed
(R)-2-hydroxyglutarate + acceptor <=> 2-oxoglutarate + reduced acceptor
Cofactor(s)
FAD.
Comment(s)
  • The enzyme has no activity with NAD(+) or NADP(+), and was assayed in vitro using artificial electron acceptors.
  • It has lower activity with (R)-lactate, (R)-2-hydroxybutyrate and meso-tartrate, and no activity with the (S) isomers.
Cross-references
BRENDA1.1.99.39
EC2PDB1.1.99.39
ExplorEnz1.1.99.39
PRIAM enzyme-specific profiles1.1.99.39
KEGG Ligand Database for Enzyme Nomenclature1.1.99.39
IUBMB Enzyme Nomenclature1.1.99.39
IntEnz1.1.99.39
MEDLINEFind literature relating to 1.1.99.39
MetaCyc1.1.99.39
Rhea expert-curated reactions1.1.99.39
UniProtKB/Swiss-Prot
O23240, D2HDH_ARATH;  Q1JPD3, D2HDH_BOVIN;  A1L258, D2HDH_DANRE;  
Q8N465, D2HDH_HUMAN;  Q8CIM3, D2HDH_MOUSE;  B8B7X6, D2HDH_ORYSI;  
Q7XI14, D2HDH_ORYSJ;  A4VGK4, D2HDH_PSEU5;  P84850, D2HDH_RAT;  
P0DV35, D2HDH_XANCL;  

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