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ENZYME

ENZYME entry: EC 1.10.5.1

Accepted Name
ribosyldihydronicotinamide dehydrogenase (quinone)
Alternative Name(s)
NQO2
NRH:quinone oxidoreductase 2
N-ribosyldihydronicotinamide dehydrogenase (quinone)
QR2
quinone reductase 2
Reaction catalysed
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = a quinol + beta-nicotinamide D-riboside
Comment(s)
  • Unlike EC 1.6.5.2, this quinone reductase cannot use NADH or NADPH; instead it uses N-ribosyl- and N-alkyldihydronicotinamides.
  • Polycyclic aromatic hydrocarbons, such as benz[a]anthracene, and the estrogens 17beta-estradiol and diethylstilbestrol are potent inhibitors, but dicoumarol is only a very weak inhibitor.
  • This enzyme can catalyze both 2-electron and 4-electron reductions, but one-electron acceptors, such as potassium ferricyanide, cannot be reduced.
  • Formerly EC 1.10.99.2.
Cross-references
BRENDA1.10.5.1
EC2PDB1.10.5.1
ExplorEnz1.10.5.1
PRIAM enzyme-specific profiles1.10.5.1
KEGG Ligand Database for Enzyme Nomenclature1.10.5.1
IUBMB Enzyme Nomenclature1.10.5.1
IntEnz1.10.5.1
MEDLINEFind literature relating to 1.10.5.1
MetaCyc1.10.5.1
Rhea expert-curated reactions1.10.5.1
UniProtKB/Swiss-Prot
P16083, NQO2_HUMANQ9JI75, NQO2_MOUSEQ5RBB9, NQO2_PONAB
Q6AY80, NQO2_RAT

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