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ENZYME

ENZYME entry: EC 1.11.1.12

PURL: https://purl.expasy.org/enzyme/EC/1.11.1.12
Accepted Name
phospholipid-hydroperoxide glutathione peroxidase
Alternative Name(s)
peroxidation-inhibiting protein
Reaction catalysed
a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O
Comment(s)
The products of action of EC 1.13.11.12 on phospholipids can act as acceptor; H2O2 can also act, but much more slowly (cf. EC 1.11.1.9).
Cross-references
BRENDA1.11.1.12
EC2PDB1.11.1.12
ExplorEnz1.11.1.12
KEGG Ligand Database for Enzyme Nomenclature1.11.1.12
IUBMB Enzyme Nomenclature1.11.1.12
MEDLINEFind literature relating to 1.11.1.12
MetaCyc1.11.1.12
Rhea expert-curated reactions1.11.1.12
UniProtKB/Swiss-Prot
P52032, GPX1_ARATHP00435, GPX1_BOVINQ0EF99, GPX1_CALJA
P07203, GPX1_HUMANQ865R2, GPX1_MACFUP11352, GPX1_MOUSE
Q0EFA0, GPX1_PANTRO24296, GPX1_PEAQ8MJ14, GPX1_PIG
Q4AEI3, GPX1_PONPYP11909, GPX1_RABITP04041, GPX1_RAT
Q4AEI1, GPX1_SAPAPQ0EF98, GPX2_CALJAP18283, GPX2_HUMAN
Q4AEH9, GPX2_HYLLAQ4AEH8, GPX2_MACFUQ9JHC0, GPX2_MOUSE
Q4AEI0, GPX2_PONPYP83645, GPX2_RATQ4AEH7, GPX2_SAPAP
Q9N2J2, GPX4_BOVINQ32QL6, GPX4_CALJAQ06652, GPX4_CITSI
O49069, GPX4_GOSHIO23968, GPX4_HELANP36969, GPX4_HUMAN
Q4AEH1, GPX4_HYLLAQ4AEH0, GPX4_MACFUQ9LEF0, GPX4_MESCR
O70325, GPX4_MOUSEP30708, GPX4_NICSYP36968, GPX4_PIG
Q4AEH2, GPX4_PONPYP36970, GPX4_RATQ4AEG9, GPX4_SAPAP
O24031, GPX4_SOLLCO23814, GPX4_SPIOLQ9FXS3, GPX4_TOBAC
O48646, GPX6_ARATHQ8SSH7, GPX_ENCCU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-