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ENZYME entry: EC 1.11.1.12

Accepted Name
Phospholipid-hydroperoxide glutathione peroxidase.
Alternative Name(s)
Peroxidation-inhibiting protein.
Reaction catalysed
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] <=> glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H(2)O
Cofactor(s)
Se(2+).
Comment(s)
The products of action of EC 1.13.11.12 on phospholipids can act as acceptor; H(2)O(2) can also act, but much more slowly (cf. EC 1.11.1.9).
Cross-references
PROSITEPDOC00396
BRENDA1.11.1.12
EC2PDB1.11.1.12
ExplorEnz1.11.1.12
PRIAM enzyme-specific profiles1.11.1.12
KEGG Ligand Database for Enzyme Nomenclature1.11.1.12
IUBMB Enzyme Nomenclature1.11.1.12
IntEnz1.11.1.12
MEDLINEFind literature relating to 1.11.1.12
MetaCyc1.11.1.12
Rhea expert-curated reactions1.11.1.12
UniProtKB/Swiss-Prot
P52032, GPX1_ARATH;  O24296, GPX1_PEA;  Q9N2J2, GPX4_BOVIN;  
Q32QL6, GPX4_CALJA;  Q06652, GPX4_CITSI;  O49069, GPX4_GOSHI;  
O23968, GPX4_HELAN;  P36969, GPX4_HUMAN;  Q4AEH1, GPX4_HYLLA;  
Q4AEH0, GPX4_MACFU;  Q9LEF0, GPX4_MESCR;  O70325, GPX4_MOUSE;  
P30708, GPX4_NICSY;  P36968, GPX4_PIG;  Q4AEH2, GPX4_PONPY;  
P36970, GPX4_RAT;  Q4AEG9, GPX4_SAPAP;  O24031, GPX4_SOLLC;  
O23814, GPX4_SPIOL;  Q9FXS3, GPX4_TOBAC;  O48646, GPX6_ARATH;  
Q8SSH7, GPX_ENCCU;  

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