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ENZYME

ENZYME entry: EC 1.13.11.12

Accepted Name
linoleate 13S-lipoxygenase
Alternative Name(s)
13-lipoperoxidase
13-lipoxidase
carotene oxidase
lipoperoxidase
lipoxidase
Reaction catalysed
  • (9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate
  • (9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate
Comment(s)
  • A common plant lipoxygenase that oxidizes linoleate and alpha- linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C13 position with (S)- configuration.
  • This enzyme produces precursors for several important compounds, including the plant hormone jasmonic acid.
  • EC 1.13.11.58 catalyzes a similar reaction at the second available position of these fatty acids.
  • Formerly EC 1.13.1.13 and EC 1.99.2.1.
Cross-references
BRENDA1.13.11.12
EC2PDB1.13.11.12
ExplorEnz1.13.11.12
PRIAM enzyme-specific profiles1.13.11.12
KEGG Ligand Database for Enzyme Nomenclature1.13.11.12
IUBMB Enzyme Nomenclature1.13.11.12
IntEnz1.13.11.12
MEDLINEFind literature relating to 1.13.11.12
MetaCyc1.13.11.12
Rhea expert-curated reactions1.13.11.12
UniProtKB/Swiss-Prot
P27479, LOX15_BOVINP16050, LOX15_HUMANP39654, LOX15_MOUSE
P16469, LOX15_PIGQ5RBE8, LOX15_PONABP12530, LOX15_RABIT
Q02759, LOX15_RATP08170, LOX1_SOYBNP93184, LOX21_HORVU
O24370, LOX21_SOLTUQ8GSM3, LOX22_HORVUQ8GSM2, LOX23_HORVU
P38418, LOX2_ARATHO24371, LOX31_SOLTUQ9LNR3, LOX3_ARATH
Q9FNX8, LOX4_ARATHQ7XV13, LOX5_ORYSJQ9CAG3, LOX6_ARATH
Q8H016, LOX6_ORYSJP27480, LOXA_PHAVUP27481, LOXB_PHAVU
P38419, LOXC1_ORYSJQ84YK8, LOXC2_ORYSJQ8RNT4, LOX_PSEAI
M5EES5, MNLOX_PLESI

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