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ENZYME entry: EC 1.13.11.12

Accepted Name
Linoleate 13S-lipoxygenase.
Alternative Name(s)
13-lipoperoxidase.
13-lipoxidase.
Carotene oxidase.
Lipoperoxidase.
Lipoxidase.
Reaction catalysed
  • Linoleate + O(2) <=> (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate
  • Alpha-linolenate + O(2) <=> (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
Cofactor(s)
Fe cation.
Comment(s)
  • A common plant lipoxygenase that oxidizes linoleate and alpha- linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C(13) position with (S)- configuration.
  • This enzyme produces precursors for several important compounds, including the plant hormone jasmonic acid.
  • EC 1.13.11.58 catalyzes a similar reaction at the second available position of these fatty acids.
  • Formerly EC 1.13.1.13 and EC 1.99.2.1.
Cross-references
PROSITEPDOC00077
BRENDA1.13.11.12
EC2PDB1.13.11.12
ExplorEnz1.13.11.12
PRIAM enzyme-specific profiles1.13.11.12
KEGG Ligand Database for Enzyme Nomenclature1.13.11.12
IUBMB Enzyme Nomenclature1.13.11.12
IntEnz1.13.11.12
MEDLINEFind literature relating to 1.13.11.12
MetaCyc1.13.11.12
UniProtKB/Swiss-Prot
P18054, LOX12_HUMAN;  P39655, LOX12_MOUSE;  F1LQ70, LOX12_RAT;  
P08170, LOX1_SOYBN;  P93184, LOX21_HORVU;  O24370, LOX21_SOLTU;  
Q8GSM3, LOX22_HORVU;  Q8GSM2, LOX23_HORVU;  P38418, LOX2_ARATH;  
O24371, LOX31_SOLTU;  Q9LNR3, LOX3_ARATH;  Q9FNX8, LOX4_ARATH;  
Q7XV13, LOX5_ORYSJ;  Q9CAG3, LOX6_ARATH;  Q8H016, LOX6_ORYSJ;  
P27480, LOXA_PHAVU;  P27481, LOXB_PHAVU;  P38419, LOXC1_ORYSJ;  
Q84YK8, LOXC2_ORYSJ;  Q8RNT4, LOX_PSEAI;  

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