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ENZYME entry: EC 1.11.1.24

Accepted Name
Thioredoxin-dependent peroxiredoxin.
Alternative Name(s)
Thioredoxin peroxidase.
Reaction catalysed
Thioredoxin + ROOH <=> thioredoxin disulfide + H(2)O + ROH
Comment(s)
  • Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins.
  • They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins.
  • The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine.
  • All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid).
  • The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes.
  • For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle.
  • In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond.
  • The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule.
  • Thioredoxin-dependent peroxiredoxins are the most common.
  • They have been reported from archaea, bacteria, fungi, plants, and animals.
  • Formerly EC 1.11.1.15.
Cross-references
BRENDA1.11.1.24
EC2PDB1.11.1.24
ExplorEnz1.11.1.24
PRIAM enzyme-specific profiles1.11.1.24
KEGG Ligand Database for Enzyme Nomenclature1.11.1.24
IUBMB Enzyme Nomenclature1.11.1.24
IntEnz1.11.1.24
MEDLINEFind literature relating to 1.11.1.24
MetaCyc1.11.1.24
UniProtKB/Swiss-Prot
P38013, AHP1_YEAST;  Q96291, BAS1A_ARATH;  Q9C5R8, BAS1B_ARATH;  
Q96468, BAS1_HORVU;  Q6ER94, BAS1_ORYSJ;  P84729, BAS1_PINST;  
O24364, BAS1_SPIOL;  P80602, BAS1_WHEAT;  P9WID8, BCPB_MYCTO;  
P9WID9, BCPB_MYCTU;  Q796Y8, BCP_BACSU;  Q9ZHF0, BCP_BUCAP;  
Q83CY8, BCP_COXBU;  P0AE54, BCP_ECO57;  P0AE53, BCP_ECOL6;  
P0AE52, BCP_ECOLI;  P44411, BCP_HAEIN;  Q9ZMU4, BCP_HELPJ;  
P55979, BCP_HELPY;  P9WIE0, BCP_MYCTO;  P9WIE1, BCP_MYCTU;  
P0AE55, BCP_SHIFL;  Q8P9V9, BCP_XANCP;  P06610, BTUE_ECOLI;  
P19476, CR29_ENTHI;  P40553, DOT5_YEAST;  O59858, GPX1_SCHPO;  
P36014, GPX1_YEAST;  P38143, GPX2_YEAST;  Q59WD3, GPX3_CANAL;  
P40581, GPX3_YEAST;  P56577, MALF2_MALFU;  P56578, MALF3_MALFU;  
Q9MB35, PERQ_SEDLI;  Q6UBI3, PERQ_SUASA;  P14292, PMPA_CANBO;  
P14293, PMPB_CANBO;  Q5E947, PRDX1_BOVIN;  P0CB50, PRDX1_CHICK;  
Q9JKY1, PRDX1_CRIGR;  Q9V3P0, PRDX1_DROME;  Q6DV14, PRDX1_GEKJA;  
Q06830, PRDX1_HUMAN;  P35700, PRDX1_MOUSE;  Q6B4U9, PRDX1_MYOLU;  
Q63716, PRDX1_RAT;  Q9BGI3, PRDX2_BOVIN;  Q8K3U7, PRDX2_CRIGR;  
P32119, PRDX2_HUMAN;  Q2PFZ3, PRDX2_MACFA;  Q61171, PRDX2_MOUSE;  
P52552, PRDX2_PIG;  Q5RC63, PRDX2_PONAB;  P35704, PRDX2_RAT;  
P35705, PRDX3_BOVIN;  P30048, PRDX3_HUMAN;  P20108, PRDX3_MOUSE;  
Q5REY3, PRDX3_PONAB;  Q9Z0V6, PRDX3_RAT;  Q9BGI2, PRDX4_BOVIN;  
P0CV91, PRDX4_CROAT;  Q555L5, PRDX4_DICDI;  Q13162, PRDX4_HUMAN;  
O08807, PRDX4_MOUSE;  Q9Z0V5, PRDX4_RAT;  Q9BGI1, PRDX5_BOVIN;  
Q9GLW7, PRDX5_CHLAE;  P30044, PRDX5_HUMAN;  P86241, PRDX5_MESAU;  
P99029, PRDX5_MOUSE;  Q9GLW9, PRDX5_PAPHA;  Q9R063, PRDX5_RAT;  
P83200, PRDX5_VULVU;  Q54SE2, PRDXL_DICDI;  Q9NL98, PRDX_ASCSU;  
A0A2Z5VKM8, PRDX_CHAMQ;  O43099, PRX5_ASPFU;  Q5ASN8, PRX5_EMENI;  
Q9Y8B8, PRX5_PENCI;  Q9LU86, PRXQ_ARATH;  Q75SY5, PRXQ_GENTR;  
P0C5D4, PRXQ_ORYSI;  P0C5D5, PRXQ_ORYSJ;  Q6QPJ6, PRXQ_POPJC;  
Q5S1S6, PRXQ_WHEAT;  Q9L3Q5, PRXU_PEPAC;  O94561, PRX_SCHPO;  
P0C5C8, REHYA_ORYSI;  P0C5C9, REHYA_ORYSJ;  P0C5D0, REHYB_ORYSI;  
P0C5D1, REHYB_ORYSJ;  O04005, REHY_ARATH;  P52571, REHY_BROSE;  
P52572, REHY_HORVU;  A2SZW8, REHY_MAIZE;  Q6E2Z6, REHY_MEDTR;  
P52574, REHY_SYNRU;  Q6W8Q2, REHY_WHEAT;  P48822, TDX1_BRUMA;  
Q21824, TDX1_CAEEL;  Q17172, TDX2_BRUMA;  Q8RCY5, TDXH1_CALS4;  
Q6L240, TDXH1_PICTO;  Q55060, TDXH1_SULME;  Q974S8, TDXH1_SULTO;  
Q9HKX0, TDXH1_THEAC;  Q8R844, TDXH2_CALS4;  Q6L140, TDXH2_PICTO;  
O33665, TDXH2_SULME;  Q96XS5, TDXH2_SULTO;  Q9HJL3, TDXH2_THEAC;  
Q9Y9L0, TDXH_AERPE;  O67024, TDXH_AQUAE;  O29969, TDXH_ARCFU;  
Q8KBN8, TDXH_CHLTE;  A2BJD9, TDXH_HYPBU;  A8A9P0, TDXH_IGNH4;  
Q58146, TDXH_METJA;  A4FWZ9, TDXH_METM5;  Q8PYP6, TDXH_METMA;  
Q6LY19, TDXH_METMP;  O26262, TDXH_METTH;  Q57109, TDXH_METTM;  
A6UPH7, TDXH_METVS;  Q74NC6, TDXH_NANEQ;  Q9UZV4, TDXH_PYRAB;  
Q8U218, TDXH_PYRFU;  O58966, TDXH_PYRHO;  P95895, TDXH_SACS2;  
A3DKL1, TDXH_STAMF;  Q5JF30, TDXH_THEKO;  Q9WZR4, TDXH_THEMA;  
A5IIX7, TDXH_THEP1;  Q979N7, TDXH_THEVO;  Q73RS4, TDXH_TREDE;  
Q90384, TDX_CYNPY;  Q8T6C4, TDX_ECHGR;  Q8SS85, TDX_ENCCU;  
P91883, TDX_FASHE;  Q91191, TDX_ONCMY;  Q26695, TDX_TRYBR;  
O74887, TPX1_SCHPO;  O66780, TPX_AQUAE;  Q9K813, TPX_BACHD;  
P80864, TPX_BACSU;  Q9PPE0, TPX_CAMJE;  Q8KED5, TPX_CHLTE;  
Q97E14, TPX_CLOAB;  P81361, TPX_CLOPA;  Q8FQH8, TPX_COREF;  
Q8NRG3, TPX_CORGL;  P0A864, TPX_ECO57;  P0A863, TPX_ECOL6;  
P0A862, TPX_ECOLI;  Q57549, TPX_HAEIN;  Q9ZKE7, TPX_HELPJ;  
O25151, TPX_HELPY;  Q72NR4, TPX_LEPIC;  Q8F7T2, TPX_LEPIN;  
Q92BC5, TPX_LISIN;  Q71Z84, TPX_LISMF;  Q8Y6U8, TPX_LISMO;  
P66953, TPX_MYCBO;  P9WG34, TPX_MYCTO;  P9WG35, TPX_MYCTU;  
Q8EPB7, TPX_OCEIH;  P57880, TPX_PASMU;  P57668, TPX_PSEAE;  
Q8XVP0, TPX_RALSO;  Q8Z7A8, TPX_SALTI;  Q8ZP65, TPX_SALTY;  
P0A866, TPX_SHIDY;  P0A865, TPX_SHIFL;  Q5HF61, TPX_STAAC;  
P66954, TPX_STAAM;  P99146, TPX_STAAN;  Q6GFZ4, TPX_STAAR;  
Q6G8L4, TPX_STAAS;  Q8NW51, TPX_STAAW;  Q5HNJ2, TPX_STAEQ;  
Q8CS58, TPX_STAES;  Q4L754, TPX_STAHJ;  Q49YE4, TPX_STAS1;  
Q8E536, TPX_STRA3;  Q8DZH0, TPX_STRA5;  P42365, TPX_STREE;  
P42366, TPX_STRGN;  Q8DUK3, TPX_STRMU;  Q04JB8, TPX_STRP2;  
P31307, TPX_STRPA;  P0C2J8, TPX_STRPN;  P0A4M6, TPX_STRR6;  
P31308, TPX_STRSA;  A5F3A2, TPX_VIBC3;  P0C6P9, TPX_VIBCH;  
Q8ZE42, TPX_YERPE;  P0CU34, TSA1B_CANAL;  Q9Y7F0, TSA1_CANAL;  
P34760, TSA1_YEAST;  Q04120, TSA2_YEAST;  Q55624, Y755_SYNY3;  
P51272, YCF42_PORPU;  Q1XDL4, YCF42_PYRYE;  

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