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ENZYME

ENZYME entry: EC 1.11.1.24

PURL: https://purl.expasy.org/enzyme/EC/1.11.1.24
Accepted Name
thioredoxin-dependent peroxiredoxin
Alternative Name(s)
thioredoxin peroxidase
Reaction catalysed
a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O
Comment(s)
  • Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins.
  • They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins.
  • The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine.
  • All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid).
  • The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes.
  • For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle.
  • In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond.
  • The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule.
  • Thioredoxin-dependent peroxiredoxins are the most common.
  • They have been reported from archaea, bacteria, fungi, plants, and animals.
  • Formerly EC 1.11.1.15.
Cross-references
Rhea expert-curated reactions1.11.1.24
ExplorEnz1.11.1.24
IUBMB Enzyme Nomenclature1.11.1.24
UniProtKB/Swiss-Prot
G0S1P8, AHP1_THET3P38013, AHP1_YEASTQ96291, BAS1A_ARATH
Q9C5R8, BAS1B_ARATHQ96468, BAS1_HORVUQ6ER94, BAS1_ORYSJ
P84729, BAS1_PINSTO24364, BAS1_SPIOLP80602, BAS1_WHEAT
P9WID8, BCPB_MYCTOP9WID9, BCPB_MYCTUQ796Y8, BCP_BACSU
Q9ZHF0, BCP_BUCAPQ83CY8, BCP_COXBUP0AE54, BCP_ECO57
P0AE53, BCP_ECOL6P0AE52, BCP_ECOLIP44411, BCP_HAEIN
Q9ZMU4, BCP_HELPJP55979, BCP_HELPYP9WIE0, BCP_MYCTO
P9WIE1, BCP_MYCTUP0AE55, BCP_SHIFLQ8P9V9, BCP_XANCP
P06610, BTUE_ECOLIP19476, CR29_ENTH1P40553, DOT5_YEAST
O59858, GPX1_SCHPOP36014, GPX1_YEASTP38143, GPX2_YEAST
Q59WD3, GPX3_CANALP40581, GPX3_YEASTO22448, GPX5_CHLRE
P56577, MALF2_MALFUP56578, MALF3_MALFUQ9MB35, PERQ_SEDLI
Q6UBI3, PERQ_SUASAP14292, PMPA_CANBOP14293, PMPB_CANBO
Q5E947, PRDX1_BOVINP0CB50, PRDX1_CHICKQ9JKY1, PRDX1_CRIGR
Q6DV14, PRDX1_GEKJAQ06830, PRDX1_HUMANP35700, PRDX1_MOUSE
Q6B4U9, PRDX1_MYOLUQ63716, PRDX1_RATQ9BGI3, PRDX2_BOVIN
Q8K3U7, PRDX2_CRIGRQ9V3P0, PRDX2_DROMEP32119, PRDX2_HUMAN
Q2PFZ3, PRDX2_MACFAQ61171, PRDX2_MOUSEP52552, PRDX2_PIG
Q5RC63, PRDX2_PONABP35704, PRDX2_RATP35705, PRDX3_BOVIN
Q9VEJ0, PRDX3_DROMEP30048, PRDX3_HUMANP20108, PRDX3_MOUSE
Q5REY3, PRDX3_PONABQ9Z0V6, PRDX3_RATQ9BGI2, PRDX4_BOVIN
P0CV91, PRDX4_CROATQ555L5, PRDX4_DICDIQ13162, PRDX4_HUMAN
O08807, PRDX4_MOUSEQ9Z0V5, PRDX4_RATQ9BGI1, PRDX5_BOVIN
Q9GLW7, PRDX5_CHLAEP30044, PRDX5_HUMANP86241, PRDX5_MESAU
P99029, PRDX5_MOUSEQ9GLW9, PRDX5_PAPHAQ9R063, PRDX5_RAT
P83200, PRDX5_VULVUQ54SE2, PRDXL_DICDIQ9NL98, PRDX_ASCSU
A0A0K3AUJ9, PRDX_CAEELA0A2Z5VKM8, PRDX_CHAMQO43099, PRX5_ASPFU
Q5ASN8, PRX5_EMENIQ9Y8B8, PRX5_PENCIQ9LU86, PRXQ_ARATH
Q75SY5, PRXQ_GENTRP0C5D4, PRXQ_ORYSIP0C5D5, PRXQ_ORYSJ
Q6QPJ6, PRXQ_POPJCQ5S1S6, PRXQ_WHEATQ9L3Q5, PRXU_PEPAC
O94561, PRX_SCHPOP0C5C8, REHYA_ORYSIP0C5C9, REHYA_ORYSJ
P0C5D0, REHYB_ORYSIP0C5D1, REHYB_ORYSJO04005, REHY_ARATH
P52571, REHY_BROSEP52572, REHY_HORVUA2SZW8, REHY_MAIZE
Q6E2Z6, REHY_MEDTRP52574, REHY_SYNRUQ6W8Q2, REHY_WHEAT
P48822, TDX1_BRUMAQ21824, TDX1_CAEELQ17172, TDX2_BRUMA
Q8RCY5, TDXH1_CALS4Q6L240, TDXH1_PICTOQ55060, TDXH1_SULME
Q974S8, TDXH1_SULTOQ9HKX0, TDXH1_THEACQ8R844, TDXH2_CALS4
Q6L140, TDXH2_PICTOO33665, TDXH2_SULMEQ96XS5, TDXH2_SULTO
Q9HJL3, TDXH2_THEACQ9Y9L0, TDXH_AERPEO67024, TDXH_AQUAE
O29969, TDXH_ARCFUQ8KBN8, TDXH_CHLTEA2BJD9, TDXH_HYPBU
A8A9P0, TDXH_IGNH4Q58146, TDXH_METJAA4FWZ9, TDXH_METM5
Q8PYP6, TDXH_METMAQ6LY19, TDXH_METMPO26262, TDXH_METTH
Q57109, TDXH_METTMA6UPH7, TDXH_METVSQ74NC6, TDXH_NANEQ
Q9UZV4, TDXH_PYRABQ8U218, TDXH_PYRFUO58966, TDXH_PYRHO
P95895, TDXH_SACS2A3DKL1, TDXH_STAMFQ5JF30, TDXH_THEKO
Q9WZR4, TDXH_THEMAA5IIX7, TDXH_THEP1Q979N7, TDXH_THEVO
Q73RS4, TDXH_TREDEQ90384, TDX_CYNPYQ8T6C4, TDX_ECHGR
Q8SS85, TDX_ENCCUP91883, TDX_FASHEQ91191, TDX_ONCMY
Q26695, TDX_TRYBRQ8IL80, TPX1_PLAF7O74887, TPX1_SCHPO
Q8I5Q6, TPX2_PLAF7O66780, TPX_AQUAEP80864, TPX_BACSU
Q9PPE0, TPX_CAMJEQ8KED5, TPX_CHLTEQ97E14, TPX_CLOAB
P81361, TPX_CLOPAQ8FQH8, TPX_COREFQ8NRG3, TPX_CORGL
P0A864, TPX_ECO57P0A863, TPX_ECOL6P0A862, TPX_ECOLI
Q57549, TPX_HAEINQ9K813, TPX_HALH5Q9ZKE7, TPX_HELPJ
O25151, TPX_HELPYQ72NR4, TPX_LEPICQ8F7T2, TPX_LEPIN
Q92BC5, TPX_LISINQ71Z84, TPX_LISMFQ8Y6U8, TPX_LISMO
P66953, TPX_MYCBOP9WG34, TPX_MYCTOP9WG35, TPX_MYCTU
Q8EPB7, TPX_OCEIHP57880, TPX_PASMUP57668, TPX_PSEAE
Q8XVP0, TPX_RALN1Q8Z7A8, TPX_SALTIQ8ZP65, TPX_SALTY
P0A866, TPX_SHIDYP0A865, TPX_SHIFLQ5HF61, TPX_STAAC
P66954, TPX_STAAMP99146, TPX_STAANQ6GFZ4, TPX_STAAR
Q6G8L4, TPX_STAASQ8NW51, TPX_STAAWQ5HNJ2, TPX_STAEQ
Q8CS58, TPX_STAESQ4L754, TPX_STAHJQ49YE4, TPX_STAS1
Q8E536, TPX_STRA3Q8DZH0, TPX_STRA5P42365, TPX_STREE
P42366, TPX_STRGNQ8DUK3, TPX_STRMUQ04JB8, TPX_STRP2
P31307, TPX_STRPAP0C2J8, TPX_STRPNP0A4M6, TPX_STRR6
P31308, TPX_STRSAA5F3A2, TPX_VIBC3P0C6P9, TPX_VIBCH
Q8ZE42, TPX_YERPEP0CU34, TSA1B_CANALA0A5C1DUY5, TSA1B_CANAR
Q9Y7F0, TSA1_CANALP34760, TSA1_YEASTQ04120, TSA2_YEAST
Q55624, Y755_SYNY3P51272, YCF42_PORPUQ1XDL4, YCF42_PYRYE
BRENDA1.11.1.24
MetaCyc1.11.1.24
KEGG Ligand Database for Enzyme Nomenclature1.11.1.24
EC2PDB1.11.1.24
MEDLINEFind literature relating to 1.11.1.24

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.1.-
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