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ENZYME

ENZYME entry: EC 1.11.1.24

Accepted Name
thioredoxin-dependent peroxiredoxin
Alternative Name(s)
thioredoxin peroxidase
Reaction catalysed
[thioredoxin]-dithiol + a hydroperoxide <=> [thioredoxin]-disulfide + an alcohol + H2O
Comment(s)
  • Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins.
  • They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins.
  • The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine.
  • All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid).
  • The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes.
  • For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle.
  • In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond.
  • The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule.
  • Thioredoxin-dependent peroxiredoxins are the most common.
  • They have been reported from archaea, bacteria, fungi, plants, and animals.
  • Formerly EC 1.11.1.15.
Cross-references
BRENDA1.11.1.24
EC2PDB1.11.1.24
ExplorEnz1.11.1.24
PRIAM enzyme-specific profiles1.11.1.24
KEGG Ligand Database for Enzyme Nomenclature1.11.1.24
IUBMB Enzyme Nomenclature1.11.1.24
IntEnz1.11.1.24
MEDLINEFind literature relating to 1.11.1.24
MetaCyc1.11.1.24
Rhea expert-curated reactions1.11.1.24
UniProtKB/Swiss-Prot
P38013, AHP1_YEASTQ96291, BAS1A_ARATHQ9C5R8, BAS1B_ARATH
Q96468, BAS1_HORVUQ6ER94, BAS1_ORYSJP84729, BAS1_PINST
O24364, BAS1_SPIOLP80602, BAS1_WHEATP9WID8, BCPB_MYCTO
P9WID9, BCPB_MYCTUQ796Y8, BCP_BACSUQ9ZHF0, BCP_BUCAP
Q83CY8, BCP_COXBUP0AE54, BCP_ECO57P0AE53, BCP_ECOL6
P0AE52, BCP_ECOLIP44411, BCP_HAEINQ9ZMU4, BCP_HELPJ
P55979, BCP_HELPYP9WIE0, BCP_MYCTOP9WIE1, BCP_MYCTU
P0AE55, BCP_SHIFLQ8P9V9, BCP_XANCPP06610, BTUE_ECOLI
P19476, CR29_ENTH1P40553, DOT5_YEASTO59858, GPX1_SCHPO
P36014, GPX1_YEASTP38143, GPX2_YEASTQ59WD3, GPX3_CANAL
P40581, GPX3_YEASTO22448, GPX5_CHLREP56577, MALF2_MALFU
P56578, MALF3_MALFUQ9MB35, PERQ_SEDLIQ6UBI3, PERQ_SUASA
P14292, PMPA_CANBOP14293, PMPB_CANBOQ5E947, PRDX1_BOVIN
P0CB50, PRDX1_CHICKQ9JKY1, PRDX1_CRIGRQ6DV14, PRDX1_GEKJA
Q06830, PRDX1_HUMANP35700, PRDX1_MOUSEQ6B4U9, PRDX1_MYOLU
Q63716, PRDX1_RATQ9BGI3, PRDX2_BOVINQ8K3U7, PRDX2_CRIGR
Q9V3P0, PRDX2_DROMEP32119, PRDX2_HUMANQ2PFZ3, PRDX2_MACFA
Q61171, PRDX2_MOUSEP52552, PRDX2_PIGQ5RC63, PRDX2_PONAB
P35704, PRDX2_RATP35705, PRDX3_BOVINQ9VEJ0, PRDX3_DROME
P30048, PRDX3_HUMANP20108, PRDX3_MOUSEQ5REY3, PRDX3_PONAB
Q9Z0V6, PRDX3_RATQ9BGI2, PRDX4_BOVINP0CV91, PRDX4_CROAT
Q555L5, PRDX4_DICDIQ13162, PRDX4_HUMANO08807, PRDX4_MOUSE
Q9Z0V5, PRDX4_RATQ9BGI1, PRDX5_BOVINQ9GLW7, PRDX5_CHLAE
P30044, PRDX5_HUMANP86241, PRDX5_MESAUP99029, PRDX5_MOUSE
Q9GLW9, PRDX5_PAPHAQ9R063, PRDX5_RATP83200, PRDX5_VULVU
Q54SE2, PRDXL_DICDIQ9NL98, PRDX_ASCSUA0A0K3AUJ9, PRDX_CAEEL
A0A2Z5VKM8, PRDX_CHAMQO43099, PRX5_ASPFUQ5ASN8, PRX5_EMENI
Q9Y8B8, PRX5_PENCIQ9LU86, PRXQ_ARATHQ75SY5, PRXQ_GENTR
P0C5D4, PRXQ_ORYSIP0C5D5, PRXQ_ORYSJQ6QPJ6, PRXQ_POPJC
Q5S1S6, PRXQ_WHEATQ9L3Q5, PRXU_PEPACO94561, PRX_SCHPO
P0C5C8, REHYA_ORYSIP0C5C9, REHYA_ORYSJP0C5D0, REHYB_ORYSI
P0C5D1, REHYB_ORYSJO04005, REHY_ARATHP52571, REHY_BROSE
P52572, REHY_HORVUA2SZW8, REHY_MAIZEQ6E2Z6, REHY_MEDTR
P52574, REHY_SYNRUQ6W8Q2, REHY_WHEATP48822, TDX1_BRUMA
Q21824, TDX1_CAEELQ17172, TDX2_BRUMAQ8RCY5, TDXH1_CALS4
Q6L240, TDXH1_PICTOQ55060, TDXH1_SULMEQ974S8, TDXH1_SULTO
Q9HKX0, TDXH1_THEACQ8R844, TDXH2_CALS4Q6L140, TDXH2_PICTO
O33665, TDXH2_SULMEQ96XS5, TDXH2_SULTOQ9HJL3, TDXH2_THEAC
Q9Y9L0, TDXH_AERPEO67024, TDXH_AQUAEO29969, TDXH_ARCFU
Q8KBN8, TDXH_CHLTEA2BJD9, TDXH_HYPBUA8A9P0, TDXH_IGNH4
Q58146, TDXH_METJAA4FWZ9, TDXH_METM5Q8PYP6, TDXH_METMA
Q6LY19, TDXH_METMPO26262, TDXH_METTHQ57109, TDXH_METTM
A6UPH7, TDXH_METVSQ74NC6, TDXH_NANEQQ9UZV4, TDXH_PYRAB
Q8U218, TDXH_PYRFUO58966, TDXH_PYRHOP95895, TDXH_SACS2
A3DKL1, TDXH_STAMFQ5JF30, TDXH_THEKOQ9WZR4, TDXH_THEMA
A5IIX7, TDXH_THEP1Q979N7, TDXH_THEVOQ73RS4, TDXH_TREDE
Q90384, TDX_CYNPYQ8T6C4, TDX_ECHGRQ8SS85, TDX_ENCCU
P91883, TDX_FASHEQ91191, TDX_ONCMYQ26695, TDX_TRYBR
O74887, TPX1_SCHPOO66780, TPX_AQUAEP80864, TPX_BACSU
Q9PPE0, TPX_CAMJEQ8KED5, TPX_CHLTEQ97E14, TPX_CLOAB
P81361, TPX_CLOPAQ8FQH8, TPX_COREFQ8NRG3, TPX_CORGL
P0A864, TPX_ECO57P0A863, TPX_ECOL6P0A862, TPX_ECOLI
Q57549, TPX_HAEINQ9K813, TPX_HALH5Q9ZKE7, TPX_HELPJ
O25151, TPX_HELPYQ72NR4, TPX_LEPICQ8F7T2, TPX_LEPIN
Q92BC5, TPX_LISINQ71Z84, TPX_LISMFQ8Y6U8, TPX_LISMO
P66953, TPX_MYCBOP9WG34, TPX_MYCTOP9WG35, TPX_MYCTU
Q8EPB7, TPX_OCEIHP57880, TPX_PASMUP57668, TPX_PSEAE
Q8XVP0, TPX_RALN1Q8Z7A8, TPX_SALTIQ8ZP65, TPX_SALTY
P0A866, TPX_SHIDYP0A865, TPX_SHIFLQ5HF61, TPX_STAAC
P66954, TPX_STAAMP99146, TPX_STAANQ6GFZ4, TPX_STAAR
Q6G8L4, TPX_STAASQ8NW51, TPX_STAAWQ5HNJ2, TPX_STAEQ
Q8CS58, TPX_STAESQ4L754, TPX_STAHJQ49YE4, TPX_STAS1
Q8E536, TPX_STRA3Q8DZH0, TPX_STRA5P42365, TPX_STREE
P42366, TPX_STRGNQ8DUK3, TPX_STRMUQ04JB8, TPX_STRP2
P31307, TPX_STRPAP0C2J8, TPX_STRPNP0A4M6, TPX_STRR6
P31308, TPX_STRSAA5F3A2, TPX_VIBC3P0C6P9, TPX_VIBCH
Q8ZE42, TPX_YERPEP0CU34, TSA1B_CANALQ9Y7F0, TSA1_CANAL
P34760, TSA1_YEASTQ04120, TSA2_YEASTQ55624, Y755_SYNY3
Q1XDL4, YCF42_NEOYEP51272, YCF42_PORPU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.-.-
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