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ENZYME entry: EC 1.11.1.8

Accepted Name
iodide peroxidase.
Alternative Name(s)
iodinase.
thyroid peroxidase.
thyroperoxidase.
TPO.
Reaction catalysed
  • 2 H(+) + H2O2 + 2 iodide <=> diiodine + 2 H2O
  • [thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide <=> [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O
  • [thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide <=> [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O
  • 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 <=> [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O
  • [thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 <=> [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O
Comment(s)
  • Thyroid peroxidase catalyzes the biosynthesis of the thyroid hormones L-thyroxine and triiodo-L-thyronine.
  • It catalyzes both the iodination of tyrosine residues in thyroglobulin (forming mono- and di-iodinated forms) and their coupling to form either L-thyroxine or triiodo-L-thyronine.
Cross-references
BRENDA1.11.1.8
EC2PDB1.11.1.8
ExplorEnz1.11.1.8
PRIAM enzyme-specific profiles1.11.1.8
KEGG Ligand Database for Enzyme Nomenclature1.11.1.8
IUBMB Enzyme Nomenclature1.11.1.8
IntEnz1.11.1.8
MEDLINEFind literature relating to 1.11.1.8
MetaCyc1.11.1.8
Rhea expert-curated reactions1.11.1.8
UniProtKB/Swiss-Prot
Q8HYB7, PERT_CANLF;  P07202, PERT_HUMAN;  P35419, PERT_MOUSE;  
P09933, PERT_PIG;  P14650, PERT_RAT;  

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