Home  |  Contact

ENZYME entry: EC 1.11.2.1

Accepted Name
Unspecific peroxygenase.
Alternative Name(s)
Haloperoxidase-peroxygenase.
Reaction catalysed
RH + H(2)O(2) <=> ROH + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Enzymes of this type include glycoproteins secreted by agaric basidiomycetes.
  • They catalyze the insertion of an oxygen atom from H(2)O(2) into a wide variety of substrates, including aromatic rings such as naphthalene, toluene, phenanthrene, pyrene and p-nitrophenol, recalcitrant heterocycles such as pyridine, dibenzofuran, various ethers (resulting in O-dealkylation) and alkanes such as propane, hexane and cyclohexane.
  • Reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, O- and N-dealkylation, bromination and one-electron oxidations.
  • They have little or no activity toward chloride.
  • Mechanistically, the catalytic cycle of unspecific (mono)- peroxygenases combines elements of the 'shunt' pathway of cytochrome P450s (a side activity that utilizes a peroxide in place of dioxygen and NAD(P)H) and the classic heme peroxidase cycle.
Cross-references
PROSITEPDOC00394
BRENDA1.11.2.1
EC2PDB1.11.2.1
ExplorEnz1.11.2.1
PRIAM enzyme-specific profiles1.11.2.1
KEGG Ligand Database for Enzyme Nomenclature1.11.2.1
IUBMB Enzyme Nomenclature1.11.2.1
IntEnz1.11.2.1
MEDLINEFind literature relating to 1.11.2.1
MetaCyc1.11.2.1
Rhea expert-curated reactions1.11.2.1
UniProtKB/Swiss-Prot
B9W4V6, APO1_AGRAE

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-