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ENZYME entry: EC 1.11.2.1
Accepted Name |
unspecific peroxygenase.
|
Alternative Name(s) |
haloperoxidase-peroxygenase. |
Reaction catalysed |
RH + H2O2 <=> ROH + H2O |
Comment(s) |
- Enzymes of this type include glycoproteins secreted by agaric
basidiomycetes.
- They catalyze the insertion of an oxygen atom from H2O2 into a wide
variety of substrates, including aromatic rings such as naphthalene,
toluene, phenanthrene, pyrene and p-nitrophenol, recalcitrant
heterocycles such as pyridine, dibenzofuran, various ethers
(resulting in O-dealkylation) and alkanes such as propane, hexane and
cyclohexane.
- Reactions catalyzed include hydroxylation, epoxidation, N-oxidation,
sulfooxidation, O- and N-dealkylation, bromination and one-electron
oxidations.
- They have little or no activity toward chloride.
- Mechanistically, the catalytic cycle of unspecific (mono)-
peroxygenases combines elements of the 'shunt' pathway of cytochrome
P450s (a side activity that utilizes a peroxide in place of dioxygen
and NAD[P]H) and the classic heme peroxidase cycle.
|
Cross-references |
BRENDA | 1.11.2.1 |
EC2PDB | 1.11.2.1 |
ExplorEnz | 1.11.2.1 |
PRIAM enzyme-specific profiles | 1.11.2.1 |
KEGG Ligand Database for Enzyme Nomenclature | 1.11.2.1 |
IUBMB Enzyme Nomenclature | 1.11.2.1 |
IntEnz | 1.11.2.1 |
MEDLINE | Find literature relating to 1.11.2.1 |
MetaCyc | 1.11.2.1 |
Rhea expert-curated reactions | 1.11.2.1 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
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