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ENZYME entry: EC

Accepted Name
unspecific peroxygenase.
Alternative Name(s)
Reaction catalysed
RH + H2O2 <=> ROH + H2O
  • Enzymes of this type include glycoproteins secreted by agaric basidiomycetes.
  • They catalyze the insertion of an oxygen atom from H2O2 into a wide variety of substrates, including aromatic rings such as naphthalene, toluene, phenanthrene, pyrene and p-nitrophenol, recalcitrant heterocycles such as pyridine, dibenzofuran, various ethers (resulting in O-dealkylation) and alkanes such as propane, hexane and cyclohexane.
  • Reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, O- and N-dealkylation, bromination and one-electron oxidations.
  • They have little or no activity toward chloride.
  • Mechanistically, the catalytic cycle of unspecific (mono)- peroxygenases combines elements of the 'shunt' pathway of cytochrome P450s (a side activity that utilizes a peroxide in place of dioxygen and NAD[P]H) and the classic heme peroxidase cycle.
PRIAM enzyme-specific profiles1.11.2.1
KEGG Ligand Database for Enzyme Nomenclature1.11.2.1
IUBMB Enzyme Nomenclature1.11.2.1
MEDLINEFind literature relating to
Rhea expert-curated reactions1.11.2.1

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