Due to maintenance work, this service and ftp://ftp.expasy.org will be unavailable from Tuesday August 23rd 18:00 until Wednesday August 24th 08:00
CEST. Apologies for the inconvenience.
ENZYME entry: EC 1.11.2.1
| Accepted Name |
|---|
| unspecific peroxygenase.
|
| Alternative Name(s) |
|---|
| haloperoxidase-peroxygenase. |
| Reaction catalysed |
|---|
| RH + H2O2 <=> ROH + H2O |
| Comment(s) |
|---|
- Enzymes of this type include glycoproteins secreted by agaric
basidiomycetes.
- They catalyze the insertion of an oxygen atom from H2O2 into a wide
variety of substrates, including aromatic rings such as naphthalene,
toluene, phenanthrene, pyrene and p-nitrophenol, recalcitrant
heterocycles such as pyridine, dibenzofuran, various ethers
(resulting in O-dealkylation) and alkanes such as propane, hexane and
cyclohexane.
- Reactions catalyzed include hydroxylation, epoxidation, N-oxidation,
sulfooxidation, O- and N-dealkylation, bromination and one-electron
oxidations.
- They have little or no activity toward chloride.
- Mechanistically, the catalytic cycle of unspecific (mono)-
peroxygenases combines elements of the 'shunt' pathway of cytochrome
P450s (a side activity that utilizes a peroxide in place of dioxygen
and NAD[P]H) and the classic heme peroxidase cycle.
|
| Cross-references |
|---|
| BRENDA | 1.11.2.1 |
| EC2PDB | 1.11.2.1 |
| ExplorEnz | 1.11.2.1 |
| PRIAM enzyme-specific profiles | 1.11.2.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.11.2.1 |
| IUBMB Enzyme Nomenclature | 1.11.2.1 |
| IntEnz | 1.11.2.1 |
| MEDLINE | Find literature relating to 1.11.2.1 |
| MetaCyc | 1.11.2.1 |
| Rhea expert-curated reactions | 1.11.2.1 |
| UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.11.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-