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ENZYME

ENZYME entry: EC 1.11.2.2

PURL: https://purl.expasy.org/enzyme/EC/1.11.2.2
Accepted Name
myeloperoxidase
Alternative Name(s)
MPO
verdoperoxidase
Reaction catalysed
chloride + H2O2 + H(+) = hypochlorous acid + H2O
Comment(s)
  • Is present in phagosomes of neutrophils and monocytes, where the hypochlorite produced is strongly bactericidal.
  • It differs from EC 1.11.1.10 in its preference for formation of hypochlorite over the chlorination of organic substrates under physiological conditions (pH 5-8).
  • Hypochlorite in turn forms a number of antimicrobial products (Cl2, chloramines, hydroxyl radical, singlet oxygen).
  • MPO also oxidizes bromide, iodide and thiocyanate.
  • In the absence of halides, it oxidizes phenols and has a moderate peroxygenase activity toward styrene.
Cross-references
BRENDA1.11.2.2
EC2PDB1.11.2.2
ExplorEnz1.11.2.2
KEGG Ligand Database for Enzyme Nomenclature1.11.2.2
IUBMB Enzyme Nomenclature1.11.2.2
MEDLINEFind literature relating to 1.11.2.2
MetaCyc1.11.2.2
Rhea expert-curated reactions1.11.2.2
UniProtKB/Swiss-Prot
P05164, PERM_HUMANP11247, PERM_MOUSE

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