Home  |  Contact
Due to scheduled maintenance work, this service will not be available from Tuesday August 23rd 06:00 pm until Wednesday August 24th 08:00 am CEST. Apologies for the inconvenience.

ENZYME entry: EC

Accepted Name
fatty-acid peroxygenase.
Alternative Name(s)
fatty acid hydroxylase.
P450 peroxygenase.
Reaction catalysed
  • a 1,2-saturated fatty acid + H2O2 <=> a 2-hydroxy fatty acid + H2O
  • 2,3-saturated fatty acid + H2O2 <=> 3-hydroxy fatty acid + H2O
  • A cytosolic heme-thiolate protein with sequence homology to P450 monooxygenases.
  • Unlike the latter, it needs neither NAD(P)H, dioxygen nor specific reductases for function.
  • Enzymes of this type are produced by bacteria (e.g. Sphingomonas paucimobilis, Bacillus subtilis).
  • Catalytic turnover rates are high compared with those of monooxygenation reactions as well as peroxide shunt reactions catalyzed by the common P450s.
  • A model substrate is myristate, but other saturated and unsaturated fatty acids are also hydroxylated.
  • Oxidizes the peroxidase substrate 3,3,5,5-tetramethylbenzidine (TMB) and peroxygenates aromatic substrates in a fatty-acid-dependent reaction.
PRIAM enzyme-specific profiles1.11.2.4
KEGG Ligand Database for Enzyme Nomenclature1.11.2.4
IUBMB Enzyme Nomenclature1.11.2.4
MEDLINEFind literature relating to
Rhea expert-curated reactions1.11.2.4

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-