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ENZYME

ENZYME entry: EC 1.13.11.11

Accepted Name
tryptophan 2,3-dioxygenase
Alternative Name(s)
indolamine 2,3-dioxygenase
indoleamine 2,3-dioxygenase
L-tryptophan 2,3-dioxygenase
L-tryptophan pyrrolase
tryptamin 2,3-dioxygenase
tryptamine 2,3-dioxygenase
tryptophanase
tryptophan oxygenase
tryptophan peroxidase
tryptophan pyrrolase
Reaction catalysed
L-tryptophan + O2 <=> N-formyl-L-kynurenine
Comment(s)
  • Catalyzes, together with EC 1.13.11.52, the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism.
  • Specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan.
  • Formerly EC 1.11.1.4 and EC 1.13.1.12.
Cross-references
BRENDA1.13.11.11
EC2PDB1.13.11.11
ExplorEnz1.13.11.11
PRIAM enzyme-specific profiles1.13.11.11
KEGG Ligand Database for Enzyme Nomenclature1.13.11.11
IUBMB Enzyme Nomenclature1.13.11.11
IntEnz1.13.11.11
MEDLINEFind literature relating to 1.13.11.11
MetaCyc1.13.11.11
Rhea expert-curated reactions1.13.11.11
UniProtKB/Swiss-Prot
Q8Y1D2, T23O1_RALSOQ8XRY7, T23O2_RALSOA7MBU6, T23OA_DANRE
Q7SY53, T23OB_DANREQ17P71, T23O_AEDAEB4RUH2, T23O_ALTMD
Q2IEC3, T23O_ANADEB4UMQ6, T23O_ANASKO77457, T23O_ANOGA
A0JUV5, T23O_ARTS2A0REX0, T23O_BACAHQ81PQ0, T23O_BACAN
Q736W5, T23O_BACC1Q63AJ2, T23O_BACCZQ6HHX9, T23O_BACHK
A9VHP7, T23O_BACMKQ6MM37, T23O_BDEBAQ7WHE8, T23O_BORBR
Q7W9B7, T23O_BORPAQ7VYS6, T23O_BORPEQ2KIQ5, T23O_BOVIN
Q89MN4, T23O_BRADUA5EQH6, T23O_BRASBA4YND6, T23O_BRASO
B1YVH2, T23O_BURA4A0KA02, T23O_BURCHB4E9J1, T23O_BURCJ
Q0BCE0, T23O_BURCMQ39DG2, T23O_BURL3A9AGH1, T23O_BURM1
A3MHE1, T23O_BURM7A2S924, T23O_BURM9Q62M99, T23O_BURMA
A1V193, T23O_BURMSB1JXI9, T23O_BURO0Q1BU34, T23O_BURO1
A3NS55, T23O_BURP0Q3JVD8, T23O_BURP1A3N6H2, T23O_BURP6
Q63WP5, T23O_BURPSA8X7X9, T23O_CAEBRQ09474, T23O_CAEEL
Q9A4E8, T23O_CAUVCQ1LK00, T23O_CUPMCQ0K7X7, T23O_CUPNH
Q55DB4, T23O_DICDIB3MQP7, T23O_DROANB3NVC6, T23O_DROER
B4JKK1, T23O_DROGRP20351, T23O_DROMEB4L629, T23O_DROMO
B4H4U3, T23O_DROPEQ29I03, T23O_DROPSB4IDV8, T23O_DROSE
Q24630, T23O_DROSIB4M818, T23O_DROVIB4MSH7, T23O_DROWI
B4PYW0, T23O_DROYAQ2N5X1, T23O_ERYLHB1YHD4, T23O_EXIS2
A4IT59, T23O_GEOTNA9B4J6, T23O_HERA2P48775, T23O_HUMAN
A6W961, T23O_KINRDQ2LD53, T23O_MAYDEP48776, T23O_MOUSE
Q1CVR6, T23O_MYXXDA1SG03, T23O_NOCSJB2SY86, T23O_PARPJ
A1VRP1, T23O_POLNAQ126P7, T23O_POLSJQ02N70, T23O_PSEAB
Q9I0Q7, T23O_PSEAEQ4KIP3, T23O_PSEF5Q84HF6, T23O_PSEFL
B2U7J7, T23O_RALPJP21643, T23O_RATQ0SFS2, T23O_RHOJR
Q5LKH2, T23O_RUEPOQ1GEF8, T23O_RUESTA4FH01, T23O_SACEN
A8GG83, T23O_SERP5B1KJM2, T23O_SHEWMA9FU01, T23O_SORC5
B2FKN7, T23O_STRMKQ95NN1, T23O_TRICAQ8PQ80, T23O_XANAC
Q3BYF4, T23O_XANC5Q4UZJ5, T23O_XANC8B0RMW5, T23O_XANCB
Q8PDA8, T23O_XANCPQ2NYM2, T23O_XANOMB2SM13, T23O_XANOP
Q5GVE4, T23O_XANORQ5U4U6, T23O_XENLAQ5EBG2, T23O_XENTR

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