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ENZYME entry: EC 1.13.11.11

Accepted Name
Tryptophan 2,3-dioxygenase.
Alternative Name(s)
Indolamine 2,3-dioxygenase.
Indoleamine 2,3-dioxygenase.
L-tryptophan 2,3-dioxygenase.
L-tryptophan pyrrolase.
Tryptamin 2,3-dioxygenase.
Tryptamine 2,3-dioxygenase.
Tryptophan oxygenase.
Tryptophan peroxidase.
Tryptophan pyrrolase.
Tryptophanase.
Reaction catalysed
L-tryptophan + O(2) <=> N-formyl-L-kynurenine
Cofactor(s)
Heme.
Comment(s)
  • Catalyzes, together with EC 1.13.11.52, the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism.
  • Specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan.
  • Formerly EC 1.11.1.4 and EC 1.13.1.12.
Cross-references
BRENDA1.13.11.11
EC2PDB1.13.11.11
ExplorEnz1.13.11.11
PRIAM enzyme-specific profiles1.13.11.11
KEGG Ligand Database for Enzyme Nomenclature1.13.11.11
IUBMB Enzyme Nomenclature1.13.11.11
IntEnz1.13.11.11
MEDLINEFind literature relating to 1.13.11.11
MetaCyc1.13.11.11
Rhea expert-curated reactions1.13.11.11
UniProtKB/Swiss-Prot
Q8Y1D2, T23O1_RALSO;  Q8XRY7, T23O2_RALSO;  A7MBU6, T23OA_DANRE;  
Q7SY53, T23OB_DANRE;  Q17P71, T23O_AEDAE;  B4RUH2, T23O_ALTMD;  
Q2IEC3, T23O_ANADE;  B4UMQ6, T23O_ANASK;  O77457, T23O_ANOGA;  
A0JUV5, T23O_ARTS2;  A0REX0, T23O_BACAH;  Q81PQ0, T23O_BACAN;  
Q736W5, T23O_BACC1;  Q63AJ2, T23O_BACCZ;  Q6HHX9, T23O_BACHK;  
A9VHP7, T23O_BACMK;  Q6MM37, T23O_BDEBA;  Q7WHE8, T23O_BORBR;  
Q7W9B7, T23O_BORPA;  Q7VYS6, T23O_BORPE;  Q2KIQ5, T23O_BOVIN;  
Q89MN4, T23O_BRADU;  A5EQH6, T23O_BRASB;  A4YND6, T23O_BRASO;  
B1YVH2, T23O_BURA4;  Q1BU34, T23O_BURCA;  B1JXI9, T23O_BURCC;  
A0KA02, T23O_BURCH;  B4E9J1, T23O_BURCJ;  Q0BCE0, T23O_BURCM;  
Q39DG2, T23O_BURL3;  A9AGH1, T23O_BURM1;  A3MHE1, T23O_BURM7;  
A2S924, T23O_BURM9;  Q62M99, T23O_BURMA;  A1V193, T23O_BURMS;  
A3NS55, T23O_BURP0;  Q3JVD8, T23O_BURP1;  A3N6H2, T23O_BURP6;  
Q63WP5, T23O_BURPS;  A8X7X9, T23O_CAEBR;  Q09474, T23O_CAEEL;  
Q9A4E8, T23O_CAUVC;  Q1LK00, T23O_CUPMC;  Q0K7X7, T23O_CUPNH;  
Q55DB4, T23O_DICDI;  B3MQP7, T23O_DROAN;  B3NVC6, T23O_DROER;  
B4JKK1, T23O_DROGR;  P20351, T23O_DROME;  B4L629, T23O_DROMO;  
B4H4U3, T23O_DROPE;  Q29I03, T23O_DROPS;  B4IDV8, T23O_DROSE;  
Q24630, T23O_DROSI;  B4M818, T23O_DROVI;  B4MSH7, T23O_DROWI;  
B4PYW0, T23O_DROYA;  Q2N5X1, T23O_ERYLH;  B1YHD4, T23O_EXIS2;  
A4IT59, T23O_GEOTN;  A9B4J6, T23O_HERA2;  P48775, T23O_HUMAN;  
A6W961, T23O_KINRD;  Q2LD53, T23O_MAYDE;  P48776, T23O_MOUSE;  
Q1CVR6, T23O_MYXXD;  A1SG03, T23O_NOCSJ;  B2SY86, T23O_PARPJ;  
A1VRP1, T23O_POLNA;  Q126P7, T23O_POLSJ;  Q02N70, T23O_PSEAB;  
Q9I0Q7, T23O_PSEAE;  Q4KIP3, T23O_PSEF5;  Q84HF6, T23O_PSEFL;  
B2U7J7, T23O_RALPJ;  P21643, T23O_RAT;  Q0SFS2, T23O_RHOJR;  
Q5LKH2, T23O_RUEPO;  Q1GEF8, T23O_RUEST;  A4FH01, T23O_SACEN;  
A8GG83, T23O_SERP5;  B1KJM2, T23O_SHEWM;  A9FU01, T23O_SORC5;  
B2FKN7, T23O_STRMK;  Q95NN1, T23O_TRICA;  Q8PQ80, T23O_XANAC;  
Q3BYF4, T23O_XANC5;  Q4UZJ5, T23O_XANC8;  B0RMW5, T23O_XANCB;  
Q8PDA8, T23O_XANCP;  Q2NYM2, T23O_XANOM;  B2SM13, T23O_XANOP;  
Q5GVE4, T23O_XANOR;  Q5U4U6, T23O_XENLA;  Q5EBG2, T23O_XENTR;  

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