ENZYME entry: EC 1.13.11.52
Accepted Name |
Indoleamine 2,3-dioxygenase.
|
Alternative Name(s) |
IDO. |
Tryptophan pyrrolase. |
Reaction catalysed |
- D-tryptophan + O(2) <=> N-formyl-D-kynurenine
- L-tryptophan + O(2) <=> N-formyl-L-kynurenine
|
Cofactor(s) |
Heme.
|
Comment(s) |
- Requires ascorbic acid and methylene blue for activity.
- Has broader substrate specificity than EC 1.13.11.11.
- Is induced in response to pathological conditions and host-defense
mechanisms.
- While the enzyme is more active with D-tryptophan than L-tryptophan,
its only known function to date is in the metabolism of L-tryptophan.
- Superoxide radicals can replace O(2) as oxygen donor.
|
Cross-references |
PROSITE | PDOC00684 |
BRENDA | 1.13.11.52 |
EC2PDB | 1.13.11.52 |
ExplorEnz | 1.13.11.52 |
PRIAM enzyme-specific profiles | 1.13.11.52 |
KEGG Ligand Database for Enzyme Nomenclature | 1.13.11.52 |
IUBMB Enzyme Nomenclature | 1.13.11.52 |
IntEnz | 1.13.11.52 |
MEDLINE | Find literature relating to 1.13.11.52 |
MetaCyc | 1.13.11.52 |
Rhea expert-curated reactions | 1.13.11.52 |
UniProtKB/Swiss-Prot |
|
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