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ENZYME entry: EC 1.13.11.52

Accepted Name
Indoleamine 2,3-dioxygenase.
Alternative Name(s)
IDO.
Tryptophan pyrrolase.
Reaction catalysed
  • D-tryptophan + O(2) <=> N-formyl-D-kynurenine
  • L-tryptophan + O(2) <=> N-formyl-L-kynurenine
Cofactor(s)
Heme.
Comment(s)
  • Requires ascorbic acid and methylene blue for activity.
  • Has broader substrate specificity than EC 1.13.11.11.
  • Is induced in response to pathological conditions and host-defense mechanisms.
  • While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan.
  • Superoxide radicals can replace O(2) as oxygen donor.
Cross-references
PROSITEPDOC00684
BRENDA1.13.11.52
EC2PDB1.13.11.52
ExplorEnz1.13.11.52
PRIAM enzyme-specific profiles1.13.11.52
KEGG Ligand Database for Enzyme Nomenclature1.13.11.52
IUBMB Enzyme Nomenclature1.13.11.52
IntEnz1.13.11.52
MEDLINEFind literature relating to 1.13.11.52
MetaCyc1.13.11.52
Rhea expert-curated reactions1.13.11.52
UniProtKB/Swiss-Prot
P14902, I23O1_HUMAN;  P28776, I23O1_MOUSE;  Q9ERD9, I23O1_RAT;  
P47125, I23O_YEAST;  A0A6G9KIF9, NANC_ASPNN;  P0DUR8, QULI_PENCI;  
Q0CG33, TPZB_ASPTN;  

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