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ENZYME entry: EC 1.13.11.48

Accepted Name
3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase.
Alternative Name(s)
(1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase.
Reaction catalysed
3-hydroxy-2-methyl-1H-quinolin-4-one + O(2) <=> N-acetylanthranilate + CO
Comment(s)
  • Does not contain a metal center or organic cofactor.
  • Fission of two C-C bonds: 2,4-dioxygenolytic cleavage with concomitant release of carbon monoxide.
  • The enzyme from Arthrobacter sp. can also act on 3-hydroxy-4- oxoquinoline, forming N-formylanthranilate and CO (cf. EC 1.13.11.47), but more slowly.
Cross-references
BRENDA1.13.11.48
EC2PDB1.13.11.48
ExplorEnz1.13.11.48
PRIAM enzyme-specific profiles1.13.11.48
KEGG Ligand Database for Enzyme Nomenclature1.13.11.48
IUBMB Enzyme Nomenclature1.13.11.48
IntEnz1.13.11.48
MEDLINEFind literature relating to 1.13.11.48
MetaCyc1.13.11.48
Rhea expert-curated reactions1.13.11.48
UniProtKB/Swiss-Prot
O31266, HOD_PAENT

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