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ENZYME entry: EC 1.13.12.17

Accepted Name
Dichloroarcyriaflavin A synthase.
Reaction catalysed
Dichlorochromopyrrolate + 4 O(2) + 4 NADH <=> dichloroarcyriaflavin A + 2 CO(2) + 6 H(2)O + 4 NAD(+)
Comment(s)
  • The conversion of dichlorochromopyrrolate to dichloroarcyriaflavin A is a complex process that involves two enzyme components.
  • RebP is an NAD-dependent cytochrome P(450) oxygenase that performs an aryl-aryl bond formation yielding the six-ring indolocarbazole scaffold.
  • Along with RebC, a flavin-dependent hydroxylase, it also catalyzes the oxidative decarboxylation of both carboxyl groups.
  • The presence of RebC ensures that the only product is the rebeccamycin aglycone dichloroarcyriaflavin A.
  • The enzymes are similar, but not identical, to StaP and StaC, which are involved in the synthesis of staurosporine.
Cross-references
PROSITEPDOC00081
BRENDA1.13.12.17
EC2PDB1.13.12.17
ExplorEnz1.13.12.17
PRIAM enzyme-specific profiles1.13.12.17
KEGG Ligand Database for Enzyme Nomenclature1.13.12.17
IUBMB Enzyme Nomenclature1.13.12.17
IntEnz1.13.12.17
MEDLINEFind literature relating to 1.13.12.17
MetaCyc1.13.12.17
Rhea expert-curated reactions1.13.12.17

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