ENZYME entry: EC 1.13.12.17
| Accepted Name |
|---|
| Dichloroarcyriaflavin A synthase.
|
| Reaction catalysed |
|---|
| Dichlorochromopyrrolate + 4 O(2) + 4 NADH <=> dichloroarcyriaflavin A + 2 CO(2) + 6 H(2)O + 4 NAD(+) |
| Comment(s) |
|---|
- The conversion of dichlorochromopyrrolate to dichloroarcyriaflavin A
is a complex process that involves two enzyme components.
- RebP is an NAD-dependent cytochrome P(450) oxygenase that performs an
aryl-aryl bond formation yielding the six-ring indolocarbazole
scaffold.
- Along with RebC, a flavin-dependent hydroxylase, it also catalyzes
the oxidative decarboxylation of both carboxyl groups.
- The presence of RebC ensures that the only product is the
rebeccamycin aglycone dichloroarcyriaflavin A.
- The enzymes are similar, but not identical, to StaP and StaC, which
are involved in the synthesis of staurosporine.
|
| Cross-references |
|---|
| PROSITE | PDOC00081 |
| BRENDA | 1.13.12.17 |
| EC2PDB | 1.13.12.17 |
| ExplorEnz | 1.13.12.17 |
| PRIAM enzyme-specific profiles | 1.13.12.17 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.13.12.17 |
| IUBMB Enzyme Nomenclature | 1.13.12.17 |
| IntEnz | 1.13.12.17 |
| MEDLINE | Find literature relating to 1.13.12.17 |
| MetaCyc | 1.13.12.17 |
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.13.12.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.13.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-