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ENZYME

ENZYME entry: EC 1.13.12.17

PURL: https://purl.expasy.org/enzyme/EC/1.13.12.17
Accepted Name
dichloroarcyriaflavin A synthase
Reaction catalysed
dichlorochromopyrrolate + 4 NADH + 4 O2 + 6 H(+) = dichloroarcyriaflavin A + 2 CO2 + 4 NAD(+) + 6 H2O
Comment(s)
  • The conversion of dichlorochromopyrrolate to dichloroarcyriaflavin A is a complex process that involves two enzyme components.
  • RebP is an NAD-dependent cytochrome P450 oxygenase that performs an aryl-aryl bond formation yielding the six-ring indolocarbazole scaffold.
  • Along with RebC, a flavin-dependent hydroxylase, it also catalyzes the oxidative decarboxylation of both carboxyl groups.
  • The presence of RebC ensures that the only product is the rebeccamycin aglycone dichloroarcyriaflavin A.
  • The enzymes are similar, but not identical, to StaP and StaC, which are involved in the synthesis of staurosporine.
Cross-references
BRENDA1.13.12.17
EC2PDB1.13.12.17
ExplorEnz1.13.12.17
KEGG Ligand Database for Enzyme Nomenclature1.13.12.17
IUBMB Enzyme Nomenclature1.13.12.17
MEDLINEFind literature relating to 1.13.12.17
MetaCyc1.13.12.17
Rhea expert-curated reactions1.13.12.17

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.13.12.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.13.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-