ENZYME entry: EC 1.13.12.17
Accepted Name |
Dichloroarcyriaflavin A synthase.
|
Reaction catalysed |
Dichlorochromopyrrolate + 4 O(2) + 4 NADH <=> dichloroarcyriaflavin A + 2 CO(2) + 6 H(2)O + 4 NAD(+) |
Comment(s) |
- The conversion of dichlorochromopyrrolate to dichloroarcyriaflavin A
is a complex process that involves two enzyme components.
- RebP is an NAD-dependent cytochrome P(450) oxygenase that performs an
aryl-aryl bond formation yielding the six-ring indolocarbazole
scaffold.
- Along with RebC, a flavin-dependent hydroxylase, it also catalyzes
the oxidative decarboxylation of both carboxyl groups.
- The presence of RebC ensures that the only product is the
rebeccamycin aglycone dichloroarcyriaflavin A.
- The enzymes are similar, but not identical, to StaP and StaC, which
are involved in the synthesis of staurosporine.
|
Cross-references |
PROSITE | PDOC00081 |
BRENDA | 1.13.12.17 |
EC2PDB | 1.13.12.17 |
ExplorEnz | 1.13.12.17 |
PRIAM enzyme-specific profiles | 1.13.12.17 |
KEGG Ligand Database for Enzyme Nomenclature | 1.13.12.17 |
IUBMB Enzyme Nomenclature | 1.13.12.17 |
IntEnz | 1.13.12.17 |
MEDLINE | Find literature relating to 1.13.12.17 |
MetaCyc | 1.13.12.17 |
Rhea expert-curated reactions | 1.13.12.17 |
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