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ENZYME entry: EC

Accepted Name
clavaminate synthase.
Alternative Name(s)
clavaminic acid synthase.
Reaction catalysed
  • 2-oxoglutarate + deoxyamidinoproclavaminate + O2 <=> amidinoproclavaminate + CO2 + succinate
  • 2-oxoglutarate + O2 + proclavaminate <=> CO2 + dihydroclavaminate + H2O + succinate
  • 2-oxoglutarate + dihydroclavaminate + O2 <=> clavaminate + CO2 + H2O + succinate
  • Catalyzes three separate oxidative reactions in the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus.
  • The first step (hydroxylation) is separated from the latter two (oxidative cyclization and desaturation) by the action of EC
  • The three reactions are all catalyzed at the same nonheme iron site.
PRIAM enzyme-specific profiles1.14.11.21
KEGG Ligand Database for Enzyme Nomenclature1.14.11.21
IUBMB Enzyme Nomenclature1.14.11.21
MEDLINEFind literature relating to
Rhea expert-curated reactions1.14.11.21
Q05581, CAS1_STRCL;  Q05582, CAS2_STRCL;  

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