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ENZYME entry: EC 1.14.11.21

Accepted Name
Clavaminate synthase.
Alternative Name(s)
Clavaminic acid synthase.
Reaction catalysed
  • Deoxyamidinoproclavaminate + 2-oxoglutarate + O(2) <=> amidinoproclavaminate + succinate + CO(2)
  • Proclavaminate + 2-oxoglutarate + O(2) <=> dihydroclavaminate + succinate + CO(2) + H(2)O
  • Dihydroclavaminate + 2-oxoglutarate + O(2) <=> clavaminate + succinate + CO(2) + H(2)O
Cofactor(s)
Fe cation.
Comment(s)
  • Catalyzes three separate oxidative reactions in the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus.
  • The first step (hydroxylation) is separated from the latter two (oxidative cyclization and desaturation) by the action of EC 3.5.3.22.
  • The three reactions are all catalyzed at the same nonheme iron site.
Cross-references
BRENDA1.14.11.21
EC2PDB1.14.11.21
ExplorEnz1.14.11.21
PRIAM enzyme-specific profiles1.14.11.21
KEGG Ligand Database for Enzyme Nomenclature1.14.11.21
IUBMB Enzyme Nomenclature1.14.11.21
IntEnz1.14.11.21
MEDLINEFind literature relating to 1.14.11.21
MetaCyc1.14.11.21
Rhea expert-curated reactions1.14.11.21
UniProtKB/Swiss-Prot
Q05581, CAS1_STRCL;  Q05582, CAS2_STRCL;  

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