Home  |  Contact

ENZYME entry: EC 1.14.11.21

Accepted Name
clavaminate synthase.
Alternative Name(s)
clavaminic acid synthase.
Reaction catalysed
  • 2-oxoglutarate + deoxyamidinoproclavaminate + O2 <=> amidinoproclavaminate + CO2 + succinate
  • 2-oxoglutarate + O2 + proclavaminate <=> CO2 + dihydroclavaminate + H2O + succinate
  • 2-oxoglutarate + dihydroclavaminate + O2 <=> clavaminate + CO2 + H2O + succinate
Comment(s)
  • Catalyzes three separate oxidative reactions in the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus.
  • The first step (hydroxylation) is separated from the latter two (oxidative cyclization and desaturation) by the action of EC 3.5.3.22.
  • The three reactions are all catalyzed at the same nonheme iron site.
Cross-references
BRENDA1.14.11.21
EC2PDB1.14.11.21
ExplorEnz1.14.11.21
PRIAM enzyme-specific profiles1.14.11.21
KEGG Ligand Database for Enzyme Nomenclature1.14.11.21
IUBMB Enzyme Nomenclature1.14.11.21
IntEnz1.14.11.21
MEDLINEFind literature relating to 1.14.11.21
MetaCyc1.14.11.21
Rhea expert-curated reactions1.14.11.21
UniProtKB/Swiss-Prot
Q05581, CAS1_STRCL;  Q05582, CAS2_STRCL;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-