ENZYME entry: EC 1.14.11.21
Accepted Name |
clavaminate synthase.
|
Alternative Name(s) |
clavaminic acid synthase. |
Reaction catalysed |
- 2-oxoglutarate + deoxyamidinoproclavaminate + O2 <=> amidinoproclavaminate + CO2 + succinate
- 2-oxoglutarate + O2 + proclavaminate <=> CO2 + dihydroclavaminate + H2O + succinate
- 2-oxoglutarate + dihydroclavaminate + O2 <=> clavaminate + CO2 + H2O + succinate
|
Comment(s) |
- Catalyzes three separate oxidative reactions in the pathway for the
biosythesis of the beta-lactamase inhibitor clavulanate in
Streptomyces clavuligerus.
- The first step (hydroxylation) is separated from the latter two
(oxidative cyclization and desaturation) by the action of
EC 3.5.3.22.
- The three reactions are all catalyzed at the same nonheme iron site.
|
Cross-references |
BRENDA | 1.14.11.21 |
EC2PDB | 1.14.11.21 |
ExplorEnz | 1.14.11.21 |
PRIAM enzyme-specific profiles | 1.14.11.21 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.21 |
IUBMB Enzyme Nomenclature | 1.14.11.21 |
IntEnz | 1.14.11.21 |
MEDLINE | Find literature relating to 1.14.11.21 |
MetaCyc | 1.14.11.21 |
Rhea expert-curated reactions | 1.14.11.21 |
UniProtKB/Swiss-Prot |
|
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