- Of the seven potential methylation sites in histones H3 (K4, K9, K27,
K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific
for Lys-36.
- Lysine residues exist in three methylation states (mono-, di- and
trimethylated).
- The enzyme preferentially demethylates the dimethyl form of Lys-36
(K36me2), which is its natural substrate, to form the monomethyl and
unmethylated forms of Lys-36.
- It can also demethylate the monomethyl- but not the trimethyl form of
Lys-36.
|
| UniProtKB/Swiss-Prot |
| Q75AL5, JHD1_ASHGO; | Q4WHB7, JHD1_ASPFU; | Q60V67, JHD1_CAEBR; |
| Q95Q98, JHD1_CAEEL; | Q5A847, JHD1_CANAL; | Q6FPL6, JHD1_CANGA; |
| P0CO41, JHD1_CRYNB; | P0CO40, JHD1_CRYNJ; | Q6BXJ4, JHD1_DEBHA; |
| Q9VHH9, JHD1_DROME; | Q5AW75, JHD1_EMENI; | Q6CIC9, JHD1_KLULA; |
| O94603, JHD1_SCHPO; | Q4P5U1, JHD1_USTMA; | Q6C423, JHD1_YARLI; |
| P40034, JHD1_YEAST; | Q9Y2K7, KDM2A_HUMAN; | P59997, KDM2A_MOUSE; |
| Q5U263, KDM2A_XENTR; | Q8NHM5, KDM2B_HUMAN; | Q6P1G2, KDM2B_MOUSE; |
| Q640I9, KDM2B_XENLA; | Q1JP61, KDM8_BOVIN; | A8E534, KDM8_DANRE; |
| Q8N371, KDM8_HUMAN; | Q9CXT6, KDM8_MOUSE; | Q497B8, KDM8_RAT; |
| B5XF11, KDM8_SALSA; | B2GUS6, KDM8_XENTR; | Q16W06, NO66_AEDAE; |
| C3XRY1, NO66_BRAFL; | A8QFQ3, NO66_BRUMA; | A8XEA2, NO66_CAEBR; |
| O01658, NO66_CAEEL; | B0WMG3, NO66_CULQU; | Q54K96, NO66_DICDI; |
| B3MSI4, NO66_DROAN; | B3NU20, NO66_DROER; | B4JMQ2, NO66_DROGR; |
| Q7K4H4, NO66_DROME; | B4L6Q5, NO66_DROMO; | B4GUZ2, NO66_DROPE; |
| B5DUH6, NO66_DROPS; | B4I100, NO66_DROSE; | B4R4H1, NO66_DROSI; |
| B4M7P8, NO66_DROVI; | B4NP88, NO66_DROWI; | B4Q068, NO66_DROYA; |
| Q9UPP1, PHF8_HUMAN; | Q80TJ7, PHF8_MOUSE; | A5PK74, RIOX1_BOVIN; |
| Q5ZMM1, RIOX1_CHICK; | A3KP59, RIOX1_DANRE; | Q9H6W3, RIOX1_HUMAN; |
| Q9JJF3, RIOX1_MOUSE; | D3ZU57, RIOX1_RAT; |
|