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ENZYME

ENZYME entry: EC 1.14.11.27

PURL: https://purl.expasy.org/enzyme/EC/1.14.11.27
Accepted Name
[histone H3]-dimethyl-L-lysine(36) demethylase
Alternative Name(s)
[histone-H3]-lysine-36 demethylase
H3-K36-specific demethylase
histone demethylase
histone-lysine (H3-K36) demethylase
JHDM1A
JmjC domain-containing histone demethylase 1A
Reaction catalysed
N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2
Comment(s)
  • Requires iron(II).
  • Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys(36).
  • Lysine residues exist in three methylation states (mono-, di- and trimethylated).
  • The enzyme preferentially demethylates the dimethyl form of Lys(36) (K36me2), which is its natural substrate, to form the monomethylated and unmethylated forms of Lys(36).
  • It can also demethylate monomethylated (but not the trimethylated) Lys(36), cf. EC 1.14.11.69.
Cross-references
BRENDA1.14.11.27
EC2PDB1.14.11.27
ExplorEnz1.14.11.27
KEGG Ligand Database for Enzyme Nomenclature1.14.11.27
IUBMB Enzyme Nomenclature1.14.11.27
MEDLINEFind literature relating to 1.14.11.27
MetaCyc1.14.11.27
Rhea expert-curated reactions1.14.11.27
UniProtKB/Swiss-Prot
Q4WHB7, JHD1_ASPFUQ60V67, JHD1_CAEBRQ95Q98, JHD1_CAEEL
Q5A847, JHD1_CANALQ6FPL6, JHD1_CANGAP0CO41, JHD1_CRYNB
P0CO40, JHD1_CRYNJQ6BXJ4, JHD1_DEBHAQ9VHH9, JHD1_DROME
Q5AW75, JHD1_EMENIQ75AL5, JHD1_EREGSQ6CIC9, JHD1_KLULA
Q4P5U1, JHD1_MYCMDO94603, JHD1_SCHPOQ6C423, JHD1_YARLI
P40034, JHD1_YEASTQ8RWR1, JMJ30_ARATHQ9Y2K7, KDM2A_HUMAN
P59997, KDM2A_MOUSEQ5U263, KDM2A_XENTRQ8NHM5, KDM2B_HUMAN
Q6P1G2, KDM2B_MOUSEQ640I9, KDM2B_XENLAA8E534, KDM8_DANRE
B5XF11, KDM8_SALSAB2GUS6, KDM8_XENTRQ16W06, NO66_AEDAE
C3XRY1, NO66_BRAFLA8QFQ3, NO66_BRUMAA8XEA2, NO66_CAEBR
O01658, NO66_CAEELB0WMG3, NO66_CULQUQ54K96, NO66_DICDI
B3MSI4, NO66_DROANB3NU20, NO66_DROERB4JMQ2, NO66_DROGR
Q7K4H4, NO66_DROMEB4L6Q5, NO66_DROMOB4GUZ2, NO66_DROPE
B5DUH6, NO66_DROPSB4I100, NO66_DROSEB4R4H1, NO66_DROSI
B4M7P8, NO66_DROVIB4NP88, NO66_DROWIB4Q068, NO66_DROYA
P0CH95, PHF8_DANREQ9UPP1, PHF8_HUMANQ80TJ7, PHF8_MOUSE
A5PK74, RIOX1_BOVINQ5ZMM1, RIOX1_CHICKA3KP59, RIOX1_DANRE
Q9H6W3, RIOX1_HUMANQ9JJF3, RIOX1_MOUSED3ZU57, RIOX1_RAT

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