ENZYME entry: EC 22.214.171.124
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|[Histone H3]-trimethyl-L-lysine(36) demethylase.
|A [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(36) + 2 2-oxoglutarate + 2 O(2) <=> a [histone H3]-N(6)-methyl-L-lysine(36) + 2 succinate + 2 formaldehyde + 2 CO(2)|
- Requires iron(II).
- This entry describes a group of enzymes that demethylate N-methylated
Lys(36) residues in the tail of the histone protein H3 (H3K36).
- This lysine residue can exist in three methylation states (mono-,
di- and trimethylated), but this group of enzymes only act on the the
tri- and di-methylated forms.
- The enzymes are dioxygenases and act by hydroxylating the methyl
group, forming an unstable hemiaminal that leaves as formaldehyde.
- Since trimethylation of H3K36 enhances transcription, this enzyme
acts as a transcription repressor.
- The enzymes that possess this activity often also catalyze the
activity of EC 126.96.36.199, cf. EC 188.8.131.52.
|PRIAM enzyme-specific profiles||184.108.40.206|
|KEGG Ligand Database for Enzyme Nomenclature||220.127.116.11|
|IUBMB Enzyme Nomenclature||18.104.22.168|
|MEDLINE||Find literature relating to 22.214.171.124|
|Rhea expert-curated reactions||126.96.36.199|
entries corresponding to 1.14.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-