Expasy logo

ENZYME

ENZYME entry: EC 1.14.11.69

PURL: https://purl.expasy.org/enzyme/EC/1.14.11.69
Accepted Name
[histone H3]-trimethyl-L-lysine(36) demethylase
Reaction catalysed
N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2
Comment(s)
  • Requires iron(II).
  • This entry describes a group of enzymes that demethylate N-methylated Lys(36) residues in the tail of the histone protein H3 (H3K36).
  • This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the tri- and di-methylated forms.
  • The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde.
  • Since trimethylation of H3K36 enhances transcription, this enzyme acts as a transcription repressor.
  • The enzymes that possess this activity often also catalyze the activity of EC 1.14.11.66, cf. EC 1.14.11.27.
Cross-references
BRENDA1.14.11.69
EC2PDB1.14.11.69
ExplorEnz1.14.11.69
KEGG Ligand Database for Enzyme Nomenclature1.14.11.69
IUBMB Enzyme Nomenclature1.14.11.69
MEDLINEFind literature relating to 1.14.11.69
MetaCyc1.14.11.69
Rhea expert-curated reactions1.14.11.69
UniProtKB/Swiss-Prot
Q8RWR1, JMJ30_ARATHQ9V333, KDM4A_DROMEO75164, KDM4A_HUMAN
Q8BW72, KDM4A_MOUSEQ5RD88, KDM4A_PONABQ9U297, KDM4_CAEEL

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-