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ENZYME entry: EC 1.14.11.69

Accepted Name
[histone H3]-trimethyl-L-lysine(36) demethylase.
Reaction catalysed
2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate
Comment(s)
  • Requires iron(II).
  • This entry describes a group of enzymes that demethylate N-methylated Lys(36) residues in the tail of the histone protein H3 (H3K36).
  • This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the tri- and di-methylated forms.
  • The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde.
  • Since trimethylation of H3K36 enhances transcription, this enzyme acts as a transcription repressor.
  • The enzymes that possess this activity often also catalyze the activity of EC 1.14.11.66, cf. EC 1.14.11.27.
Cross-references
BRENDA1.14.11.69
EC2PDB1.14.11.69
ExplorEnz1.14.11.69
PRIAM enzyme-specific profiles1.14.11.69
KEGG Ligand Database for Enzyme Nomenclature1.14.11.69
IUBMB Enzyme Nomenclature1.14.11.69
IntEnz1.14.11.69
MEDLINEFind literature relating to 1.14.11.69
MetaCyc1.14.11.69
Rhea expert-curated reactions1.14.11.69
UniProtKB/Swiss-Prot
Q8RWR1, JMJ30_ARATH;  Q9V333, KDM4A_DROME;  O75164, KDM4A_HUMAN;  
Q8BW72, KDM4A_MOUSE;  Q5RD88, KDM4A_PONAB;  Q9U297, KDM4_CAEEL;  

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