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ENZYME entry: EC 1.14.11.69
Accepted Name |
[histone H3]-trimethyl-L-lysine(36) demethylase.
|
Reaction catalysed |
2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate |
Comment(s) |
- Requires iron(II).
- This entry describes a group of enzymes that demethylate N-methylated
Lys(36) residues in the tail of the histone protein H3 (H3K36).
- This lysine residue can exist in three methylation states (mono-,
di- and trimethylated), but this group of enzymes only act on the the
tri- and di-methylated forms.
- The enzymes are dioxygenases and act by hydroxylating the methyl
group, forming an unstable hemiaminal that leaves as formaldehyde.
- Since trimethylation of H3K36 enhances transcription, this enzyme
acts as a transcription repressor.
- The enzymes that possess this activity often also catalyze the
activity of EC 1.14.11.66, cf. EC 1.14.11.27.
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Cross-references |
BRENDA | 1.14.11.69 |
EC2PDB | 1.14.11.69 |
ExplorEnz | 1.14.11.69 |
PRIAM enzyme-specific profiles | 1.14.11.69 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.69 |
IUBMB Enzyme Nomenclature | 1.14.11.69 |
IntEnz | 1.14.11.69 |
MEDLINE | Find literature relating to 1.14.11.69 |
MetaCyc | 1.14.11.69 |
Rhea expert-curated reactions | 1.14.11.69 |
UniProtKB/Swiss-Prot |
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