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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Hypoxia-inducible factor-asparagine dioxygenase.
Alternative Name(s)
HIF hydroxylase.
Reaction catalysed
Hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O(2) <=> hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO(2)
Fe(2+); L-ascorbate.
  • Contains iron, and requires ascorbate.
  • Catalyzes hydroxylation of an asparagine in the C-terminal transcriptional activation domain of HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which reduces its interaction with the transcriptional coactivator protein p300.
  • The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.
PRIAM enzyme-specific profiles1.14.11.30
KEGG Ligand Database for Enzyme Nomenclature1.14.11.30
IUBMB Enzyme Nomenclature1.14.11.30
MEDLINEFind literature relating to

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.11.-
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