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ENZYME entry: EC 1.14.11.31

Accepted Name
Thebaine 6-O-demethylase.
Reaction catalysed
Thebaine + 2-oxoglutarate + O(2) <=> neopinone + formaldehyde + succinate + CO(2)
Cofactor(s)
Fe(2+).
Comment(s)
  • Requires Fe(2+).
  • Catalyzes a step in morphine biosynthesis.
  • The product neopinione spontaneously rearranges to the more stable codeinone.
  • The enzyme also catalyzes the 6-O-demethylation of oripavine to morphinone, with lower efficiency.
Cross-references
BRENDA1.14.11.31
EC2PDB1.14.11.31
ExplorEnz1.14.11.31
PRIAM enzyme-specific profiles1.14.11.31
KEGG Ligand Database for Enzyme Nomenclature1.14.11.31
IUBMB Enzyme Nomenclature1.14.11.31
IntEnz1.14.11.31
MEDLINEFind literature relating to 1.14.11.31
MetaCyc1.14.11.31
Rhea expert-curated reactions1.14.11.31
UniProtKB/Swiss-Prot
D4N500, DIOX1_PAPSO

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