ENZYME entry: EC 1.14.11.31
| Accepted Name |
|---|
| Thebaine 6-O-demethylase.
|
| Reaction catalysed |
|---|
| Thebaine + 2-oxoglutarate + O(2) <=> neopinone + formaldehyde + succinate + CO(2) |
| Cofactor(s) |
|---|
| Fe(2+).
|
| Comment(s) |
|---|
- Requires Fe(2+).
- Catalyzes a step in morphine biosynthesis.
- The product neopinione spontaneously rearranges to the more stable
codeinone.
- The enzyme also catalyzes the 6-O-demethylation of oripavine to
morphinone, with lower efficiency.
|
| Cross-references |
|---|
| BRENDA | 1.14.11.31 |
| EC2PDB | 1.14.11.31 |
| ExplorEnz | 1.14.11.31 |
| PRIAM enzyme-specific profiles | 1.14.11.31 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.31 |
| IUBMB Enzyme Nomenclature | 1.14.11.31 |
| IntEnz | 1.14.11.31 |
| MEDLINE | Find literature relating to 1.14.11.31 |
| MetaCyc | 1.14.11.31 |
| UniProtKB/Swiss-Prot |
|
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