Expasy logo

ENZYME

ENZYME entry: EC 1.14.11.31

Accepted Name
thebaine 6-O-demethylase
Reaction catalysed
2-oxoglutarate + O2 + thebaine <=> CO2 + formaldehyde + neopinone + succinate
Comment(s)
  • Requires Fe(2+).
  • Catalyzes a step in morphine biosynthesis.
  • The product neopinione spontaneously rearranges to the more stable codeinone.
  • The enzyme also catalyzes the 6-O-demethylation of oripavine to morphinone, with lower efficiency.
Cross-references
BRENDA1.14.11.31
EC2PDB1.14.11.31
ExplorEnz1.14.11.31
PRIAM enzyme-specific profiles1.14.11.31
KEGG Ligand Database for Enzyme Nomenclature1.14.11.31
IUBMB Enzyme Nomenclature1.14.11.31
IntEnz1.14.11.31
MEDLINEFind literature relating to 1.14.11.31
MetaCyc1.14.11.31
Rhea expert-curated reactions1.14.11.31
UniProtKB/Swiss-Prot
D4N500, DIOX1_PAPSOD4N502, DIOX3_PAPSO

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-