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ENZYME entry: EC 1.14.11.31
Accepted Name |
thebaine 6-O-demethylase.
|
Reaction catalysed |
2-oxoglutarate + O2 + thebaine <=> CO2 + formaldehyde + neopinone + succinate |
Comment(s) |
- Requires Fe(2+).
- Catalyzes a step in morphine biosynthesis.
- The product neopinione spontaneously rearranges to the more stable
codeinone.
- The enzyme also catalyzes the 6-O-demethylation of oripavine to
morphinone, with lower efficiency.
|
Cross-references |
BRENDA | 1.14.11.31 |
EC2PDB | 1.14.11.31 |
ExplorEnz | 1.14.11.31 |
PRIAM enzyme-specific profiles | 1.14.11.31 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.31 |
IUBMB Enzyme Nomenclature | 1.14.11.31 |
IntEnz | 1.14.11.31 |
MEDLINE | Find literature relating to 1.14.11.31 |
MetaCyc | 1.14.11.31 |
Rhea expert-curated reactions | 1.14.11.31 |
UniProtKB/Swiss-Prot |
|
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UniProtKB/Swiss-Prot entries corresponding to 1.14.11.-
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