ENZYME entry: EC 1.14.11.49
| Accepted Name | |||
|---|---|---|---|
| uridine-5'-phosphate dioxygenase | |||
| Reaction catalysed | |||
| 2-oxoglutarate + O2 + UMP <=> CO2 + phosphate + succinate + uridine-5'-aldehyde | |||
| Comment(s) | |||
| The enzyme catalyzes a net dephosphorylation and oxidation of UMP to generate 5'-dehydrouridine, the first intermediate in the biosynthesis of the unusual aminoribosyl moiety found in several C(7)-furanosyl nucleosides such as A-90289s, caprazamycins, liposidomycins, muraymycins and FR-900453. | |||
| Cross-references | |||
| BRENDA | 1.14.11.49 | ||
| EC2PDB | 1.14.11.49 | ||
| ExplorEnz | 1.14.11.49 | ||
| PRIAM enzyme-specific profiles | 1.14.11.49 | ||
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.49 | ||
| IUBMB Enzyme Nomenclature | 1.14.11.49 | ||
| IntEnz | 1.14.11.49 | ||
| MEDLINE | Find literature relating to 1.14.11.49 | ||
| MetaCyc | 1.14.11.49 | ||
| Rhea expert-curated reactions | 1.14.11.49 | ||
| UniProtKB/Swiss-Prot |
| ||
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