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ENZYME

ENZYME entry: EC 1.14.11.49

Accepted Name
uridine-5'-phosphate dioxygenase
Reaction catalysed
2-oxoglutarate + O2 + UMP = CO2 + phosphate + succinate + uridine-5'-aldehyde
Comment(s)
The enzyme catalyzes a net dephosphorylation and oxidation of UMP to generate 5'-dehydrouridine, the first intermediate in the biosynthesis of the unusual aminoribosyl moiety found in several C(7)-furanosyl nucleosides such as A-90289s, caprazamycins, liposidomycins, muraymycins and FR-900453.
Cross-references
BRENDA1.14.11.49
EC2PDB1.14.11.49
ExplorEnz1.14.11.49
PRIAM enzyme-specific profiles1.14.11.49
KEGG Ligand Database for Enzyme Nomenclature1.14.11.49
IUBMB Enzyme Nomenclature1.14.11.49
IntEnz1.14.11.49
MEDLINEFind literature relating to 1.14.11.49
MetaCyc1.14.11.49
Rhea expert-curated reactions1.14.11.49
UniProtKB/Swiss-Prot
A0A0E3USC3, UMPDO_AMYSPD4QF25, UMPDO_STRSQ

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