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ENZYME entry: EC 1.14.11.49

Accepted Name
Uridine-5'-phosphate dioxygenase.
Reaction catalysed
UMP + 2-oxoglutarate + O(2) <=> 5'-dehydrouridine + succinate + CO(2) + phosphate
Cofactor(s)
Fe(2+).
Comment(s)
The enzyme catalyzes a net dephosphorylation and oxidation of UMP to generate 5'-dehydrouridine, the first intermediate in the biosynthesis of the unusual aminoribosyl moiety found in several C(7)-furanosyl nucleosides such as A-90289s, caprazamycins, liposidomycins, muraymycins and FR-900453.
Cross-references
BRENDA1.14.11.49
EC2PDB1.14.11.49
ExplorEnz1.14.11.49
PRIAM enzyme-specific profiles1.14.11.49
KEGG Ligand Database for Enzyme Nomenclature1.14.11.49
IUBMB Enzyme Nomenclature1.14.11.49
IntEnz1.14.11.49
MEDLINEFind literature relating to 1.14.11.49
MetaCyc1.14.11.49
Rhea expert-curated reactions1.14.11.49
UniProtKB/Swiss-Prot
D4QF25, LIPL_STRSQ

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