ENZYME entry: EC 1.14.11.49
Accepted Name | ||
---|---|---|
uridine-5'-phosphate dioxygenase | ||
Reaction catalysed | ||
2-oxoglutarate + O2 + UMP <=> CO2 + phosphate + succinate + uridine-5'-aldehyde | ||
Comment(s) | ||
The enzyme catalyzes a net dephosphorylation and oxidation of UMP to generate 5'-dehydrouridine, the first intermediate in the biosynthesis of the unusual aminoribosyl moiety found in several C(7)-furanosyl nucleosides such as A-90289s, caprazamycins, liposidomycins, muraymycins and FR-900453. | ||
Cross-references | ||
BRENDA | 1.14.11.49 | |
EC2PDB | 1.14.11.49 | |
ExplorEnz | 1.14.11.49 | |
PRIAM enzyme-specific profiles | 1.14.11.49 | |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.49 | |
IUBMB Enzyme Nomenclature | 1.14.11.49 | |
IntEnz | 1.14.11.49 | |
MEDLINE | Find literature relating to 1.14.11.49 | |
MetaCyc | 1.14.11.49 | |
Rhea expert-curated reactions | 1.14.11.49 | |
UniProtKB/Swiss-Prot |
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