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ENZYME

ENZYME entry: EC 1.14.11.62

PURL: https://purl.expasy.org/enzyme/EC/1.14.11.62
Accepted Name
trans-4-coumaroyl-CoA 2'-hydroxylase
Reaction catalysed
(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 = (E)-2,4-dihydroxycinnamoyl-CoA + succinate + CO2
Comment(s)
  • Requires iron(II) and ascorbate.
  • The product spontaneously undergoes trans-cis isomerization followed by lactonization and cyclization, liberating CoA and forming umbelliferone.
  • The enzymes from the plants Ruta graveolens and Ipomoea batatas also act on trans-feruloyl-CoA (cf. EC 1.14.11.61).
Cross-references
BRENDA1.14.11.62
EC2PDB1.14.11.62
ExplorEnz1.14.11.62
KEGG Ligand Database for Enzyme Nomenclature1.14.11.62
IUBMB Enzyme Nomenclature1.14.11.62
MEDLINEFind literature relating to 1.14.11.62
MetaCyc1.14.11.62
Rhea expert-curated reactions1.14.11.62
UniProtKB/Swiss-Prot
A0A023GS28, DIOX1_RUTGRA0A023GS29, DIOX2_RUTGRW5QJZ5, DIOX4_RUTGR
G9M9M4, F6H21_IPOBAG9M9M3, F6H22_IPOBAG9M9M5, F6H28_IPOBA

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