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ENZYME entry: EC 1.14.11.61

Accepted Name
Feruloyl-CoA 6-hydroxylase.
Reaction catalysed
Trans-feruloyl-CoA + 2-oxoglutarate + O(2) <=> trans-6-hydroxy-feruloyl-CoA + succinate + CO(2)
Comment(s)
  • Requires iron(II) and ascorbate.
  • The product spontaneously undergoes trans-cis isomerization and lactonization to form scopoletin, liberating CoA in the process.
  • The enzymes from the plants Ruta graveolens and Ipomoea batatas also act on trans-4-coumaroyl-CoA.
  • Cf. EC 1.14.11.62.
Cross-references
BRENDA1.14.11.61
EC2PDB1.14.11.61
ExplorEnz1.14.11.61
PRIAM enzyme-specific profiles1.14.11.61
KEGG Ligand Database for Enzyme Nomenclature1.14.11.61
IUBMB Enzyme Nomenclature1.14.11.61
IntEnz1.14.11.61
MEDLINEFind literature relating to 1.14.11.61
MetaCyc1.14.11.61
UniProtKB/Swiss-Prot
A0A023GS28, DIOX1_RUTGR;  A0A023GS29, DIOX2_RUTGR;  W5QJZ5, DIOX4_RUTGR;  
G9M9M0, F6H11_IPOBA;  G9M9M1, F6H12_IPOBA;  G9M9M2, F6H13_IPOBA;  
Q9LHN8, F6H1_ARATH;  G9M9M4, F6H21_IPOBA;  G9M9M3, F6H22_IPOBA;  
G9M9M5, F6H28_IPOBA;  Q9C899, F6H2_ARATH;  

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