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ENZYME

ENZYME entry: EC 1.14.11.61

PURL: https://purl.expasy.org/enzyme/EC/1.14.11.61
Accepted Name
feruloyl-CoA 6-hydroxylase
Reaction catalysed
(E)-feruloyl-CoA + 2-oxoglutarate + O2 = (E)-6-hydroxyferuloyl-CoA + succinate + CO2
Comment(s)
  • Requires iron(II) and ascorbate.
  • The product spontaneously undergoes trans-cis isomerization and lactonization to form scopoletin, liberating CoA in the process.
  • The enzymes from the plants Ruta graveolens and Ipomoea batatas also act on trans-4-coumaroyl-CoA. cf. EC 1.14.11.62.
Cross-references
BRENDA1.14.11.61
EC2PDB1.14.11.61
ExplorEnz1.14.11.61
KEGG Ligand Database for Enzyme Nomenclature1.14.11.61
IUBMB Enzyme Nomenclature1.14.11.61
MEDLINEFind literature relating to 1.14.11.61
MetaCyc1.14.11.61
Rhea expert-curated reactions1.14.11.61
UniProtKB/Swiss-Prot
A0A023GS28, DIOX1_RUTGRA0A023GS29, DIOX2_RUTGRW5QJZ5, DIOX4_RUTGR
G9M9M0, F6H11_IPOBAG9M9M1, F6H12_IPOBAG9M9M2, F6H13_IPOBA
Q9LHN8, F6H1_ARATHG9M9M4, F6H21_IPOBAG9M9M3, F6H22_IPOBA
G9M9M5, F6H28_IPOBAQ9C899, F6H2_ARATH

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