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ENZYME entry: EC 1.14.11.66

Accepted Name
[Histone H3]-trimethyl-L-lysine(9) demethylase.
Reaction catalysed
A [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(9) + 2 2-oxoglutarate + 2 O(2) <=> a [histone H3]-N(6)-methyl-L-lysine(9) + 2 succinate + 2 formaldehyde + 2 CO(2)
Comment(s)
  • Requires iron(II).
  • This entry describes a group of enzymes that demethylate N-methylated Lys-9 residues in the tail of the histone protein H3 (H3K9).
  • This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the tri- and di-methylated forms.
  • The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde, cf. EC 1.14.11.65.
Cross-references
BRENDA1.14.11.66
EC2PDB1.14.11.66
ExplorEnz1.14.11.66
PRIAM enzyme-specific profiles1.14.11.66
KEGG Ligand Database for Enzyme Nomenclature1.14.11.66
IUBMB Enzyme Nomenclature1.14.11.66
IntEnz1.14.11.66
MEDLINEFind literature relating to 1.14.11.66
MetaCyc1.14.11.66
UniProtKB/Swiss-Prot
Q9V333, KDM4A_DROME;  O75164, KDM4A_HUMAN;  Q8BW72, KDM4A_MOUSE;  
Q5RD88, KDM4A_PONAB;  Q9V6L0, KDM4B_DROME;  O94953, KDM4B_HUMAN;  
Q91VY5, KDM4B_MOUSE;  Q9H3R0, KDM4C_HUMAN;  Q8VCD7, KDM4C_MOUSE;  
Q6B0I6, KDM4D_HUMAN;  Q3U2K5, KDM4D_MOUSE;  A1A5Q5, KDM4D_RAT;  
B2RXH2, KDM4E_HUMAN;  Q9U297, KDM4_CAEEL;  

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