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ENZYME

ENZYME entry: EC 1.14.11.66

PURL: https://purl.expasy.org/enzyme/EC/1.14.11.66
Accepted Name
[histone H3]-trimethyl-L-lysine(9) demethylase
Reaction catalysed
N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2
Comment(s)
  • Requires iron(II).
  • This entry describes a group of enzymes that demethylate N-methylated Lys-9 residues in the tail of the histone protein H3 (H3K9).
  • This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the tri- and di-methylated forms.
  • The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde, cf. EC 1.14.11.65.
Cross-references
BRENDA1.14.11.66
EC2PDB1.14.11.66
ExplorEnz1.14.11.66
KEGG Ligand Database for Enzyme Nomenclature1.14.11.66
IUBMB Enzyme Nomenclature1.14.11.66
MEDLINEFind literature relating to 1.14.11.66
MetaCyc1.14.11.66
Rhea expert-curated reactions1.14.11.66
UniProtKB/Swiss-Prot
Q336N8, JM706_ORYSJQ9V333, KDM4A_DROMEO75164, KDM4A_HUMAN
Q8BW72, KDM4A_MOUSEQ5RD88, KDM4A_PONABQ9V6L0, KDM4B_DROME
O94953, KDM4B_HUMANQ91VY5, KDM4B_MOUSEQ9H3R0, KDM4C_HUMAN
Q8VCD7, KDM4C_MOUSEQ6B0I6, KDM4D_HUMANQ3U2K5, KDM4D_MOUSE
A1A5Q5, KDM4D_RATB2RXH2, KDM4E_HUMANA0A1W2PPD8, KDM4F_HUMAN
Q9U297, KDM4_CAEEL

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