ENZYME entry: EC 1.14.11.67
| Accepted Name |
|---|
| [Histone H3]-trimethyl-L-lysine(4) demethylase.
|
| Reaction catalysed |
|---|
| A [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(4) + 3 2-oxoglutarate + 3 O(2) <=> a [histone H3]-L-lysine(4) + 3 succinate + 3 formaldehyde + 3 CO(2) |
| Comment(s) |
|---|
- Requires iron(II).
- This entry describes a group of enzymes that demethylate N-methylated
L-lysine residues at position 4 of histone H3 (H3K4).
- The enzymes are dioxygenases and act by hydroxylating the methyl
group, forming an unstable hemiaminal that leaves as formaldehyde.
- They can act on tri-, di-, and mono-methylated forms.
|
| Cross-references |
|---|
| BRENDA | 1.14.11.67 |
| EC2PDB | 1.14.11.67 |
| ExplorEnz | 1.14.11.67 |
| PRIAM enzyme-specific profiles | 1.14.11.67 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.67 |
| IUBMB Enzyme Nomenclature | 1.14.11.67 |
| IntEnz | 1.14.11.67 |
| MEDLINE | Find literature relating to 1.14.11.67 |
| MetaCyc | 1.14.11.67 |
| Rhea expert-curated reactions | 1.14.11.67 |
| UniProtKB/Swiss-Prot |
| P47156, JHD2_YEAST; | Q53WJ1, JM703_ORYSJ; | Q8GUI6, JMJ14_ARATH; |
| Q6IQX0, KD5BB_DANRE; | P29375, KDM5A_HUMAN; | Q3UXZ9, KDM5A_MOUSE; |
| Q5F3R2, KDM5B_CHICK; | Q9UGL1, KDM5B_HUMAN; | Q80Y84, KDM5B_MOUSE; |
| Q38JA7, KDM5C_CANLF; | P41228, KDM5C_CRIGR; | P41229, KDM5C_HUMAN; |
| P41230, KDM5C_MOUSE; | A1YVX4, KDM5C_PIG; | Q30DN6, KDM5D_CANLF; |
| Q9BY66, KDM5D_HUMAN; | Q62240, KDM5D_MOUSE; | Q5XUN4, KDM5D_PANTR; |
| Q61T02, KDM5_CAEBR; | Q23541, KDM5_CAEEL; | Q9VMJ7, KDM5_DROME; |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.14.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-