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ENZYME entry: EC 1.14.11.67

Accepted Name
[Histone H3]-trimethyl-L-lysine(4) demethylase.
Reaction catalysed
A [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(4) + 3 2-oxoglutarate + 3 O(2) <=> a [histone H3]-L-lysine(4) + 3 succinate + 3 formaldehyde + 3 CO(2)
Comment(s)
  • Requires iron(II).
  • This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 4 of histone H3 (H3K4).
  • The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde.
  • They can act on tri-, di-, and mono-methylated forms.
Cross-references
BRENDA1.14.11.67
EC2PDB1.14.11.67
ExplorEnz1.14.11.67
PRIAM enzyme-specific profiles1.14.11.67
KEGG Ligand Database for Enzyme Nomenclature1.14.11.67
IUBMB Enzyme Nomenclature1.14.11.67
IntEnz1.14.11.67
MEDLINEFind literature relating to 1.14.11.67
MetaCyc1.14.11.67

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