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ENZYME entry: EC 1.14.11.67

Accepted Name
[histone H3]-trimethyl-L-lysine(4) demethylase.
Reaction catalysed
3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 <=> 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate
Comment(s)
  • Requires iron(II).
  • This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 4 of histone H3 (H3K4).
  • The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde.
  • They can act on tri-, di-, and mono-methylated forms.
Cross-references
BRENDA1.14.11.67
EC2PDB1.14.11.67
ExplorEnz1.14.11.67
PRIAM enzyme-specific profiles1.14.11.67
KEGG Ligand Database for Enzyme Nomenclature1.14.11.67
IUBMB Enzyme Nomenclature1.14.11.67
IntEnz1.14.11.67
MEDLINEFind literature relating to 1.14.11.67
MetaCyc1.14.11.67
Rhea expert-curated reactions1.14.11.67
UniProtKB/Swiss-Prot
P47156, JHD2_YEAST;  Q53WJ1, JM703_ORYSJ;  Q8GUI6, JMJ14_ARATH;  
F4I240, JMJ17_ARATH;  Q6IQX0, KD5BB_DANRE;  P29375, KDM5A_HUMAN;  
Q3UXZ9, KDM5A_MOUSE;  Q5F3R2, KDM5B_CHICK;  Q9UGL1, KDM5B_HUMAN;  
Q80Y84, KDM5B_MOUSE;  Q38JA7, KDM5C_CANLF;  P41228, KDM5C_CRIGR;  
P41229, KDM5C_HUMAN;  P41230, KDM5C_MOUSE;  A1YVX4, KDM5C_PIG;  
Q30DN6, KDM5D_CANLF;  Q9BY66, KDM5D_HUMAN;  Q62240, KDM5D_MOUSE;  
Q5XUN4, KDM5D_PANTR;  Q61T02, KDM5_CAEBR;  Q23541, KDM5_CAEEL;  
Q9VMJ7, KDM5_DROME;  

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