ENZYME entry: EC 1.14.11.67
| Accepted Name |
|---|
| [Histone H3]-trimethyl-L-lysine(4) demethylase.
|
| Reaction catalysed |
|---|
| A [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(4) + 3 2-oxoglutarate + 3 O(2) <=> a [histone H3]-L-lysine(4) + 3 succinate + 3 formaldehyde + 3 CO(2) |
| Comment(s) |
|---|
- Requires iron(II).
- This entry describes a group of enzymes that demethylate N-methylated
L-lysine residues at position 4 of histone H3 (H3K4).
- The enzymes are dioxygenases and act by hydroxylating the methyl
group, forming an unstable hemiaminal that leaves as formaldehyde.
- They can act on tri-, di-, and mono-methylated forms.
|
| Cross-references |
|---|
| BRENDA | 1.14.11.67 |
| EC2PDB | 1.14.11.67 |
| ExplorEnz | 1.14.11.67 |
| PRIAM enzyme-specific profiles | 1.14.11.67 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.67 |
| IUBMB Enzyme Nomenclature | 1.14.11.67 |
| IntEnz | 1.14.11.67 |
| MEDLINE | Find literature relating to 1.14.11.67 |
| MetaCyc | 1.14.11.67 |
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